Recent Trends and Future Directions in 3D Printing of Biocompatible Polymers DOI Creative Commons
Maryam Aftab, S. Ikram, Muneeb Ullah

et al.

Journal of Manufacturing and Materials Processing, Journal Year: 2025, Volume and Issue: 9(4), P. 129 - 129

Published: April 14, 2025

Three-dimensional (3D) bioprinting using biocompatible polymers has emerged as a revolutionary technique in tissue engineering and regenerative medicine. These biopolymers mimic the extracellular matrix (ECM) enhance cellular behavior. The current review presents recent advancements additive manufacturing processes including Stereolithography (SLA), Fused Filament Fabrication (FFF), Selective Laser Sintering (SLS), inkjet printing. It also explores fundamentals of 3D printing properties for bioprinting. By mixing biopolymers, enhancing rheological characteristics, adding bioactive components, further have been made organ transplantation, drug development, engineering. As research progresses, potential to fundamentally transform healthcare system is becoming obvious clear. However, therapeutic printed structures hindered by issues such material anisotropy, poor mechanical properties, need more biodegradable architectures. Future should concentrate on optimizing process sophisticated computational techniques, systematically examining characteristics customizing bioinks different cell types, exploring sustainable materials.

Language: Английский

Optimizing scaffold pore size for tissue engineering: insights across various tissue types DOI Creative Commons
Fariza Mukasheva,

Laura Adilova,

Aibek Dyussenbinov

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 12, 2024

Scaffold porosity is a critical factor in replicating the complex vivo microenvironment, directly influencing cellular interactions, migration, nutrient transfer, vascularization, and formation of functional tissues. For optimal tissue formation, scaffold design must account for various parameters, including material composition, morphology, mechanical properties, compatibility. This review highlights importance interconnected pore size, emphasizing their impact on behavior across several engineering domains, such as skin, bone, cardiovascular, lung Specific size ranges enhance functionality different tissues: small pores (∼1–2 µm) aid epidermal cell attachment skin regeneration, moderate (∼2–12 support dermal larger (∼40–100 facilitate vascular structures. bone engineering, multi-layered scaffolds with smaller (50–100 foster attachment, while (200–400 diffusion angiogenesis. Cardiovascular tissues benefit from sizes (∼25–60 to balance integration diffusion. By addressing challenges optimizing distributions, this provides insights into innovations, ultimately advancing regeneration strategies.

Language: Английский

Citations

19
The Role of Polysaccharide-based Biodegradable Soft Polymers in the Healthcare Sector DOI Creative Commons
Zia Ullah Arif

Advanced Industrial and Engineering Polymer Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.

Language: Английский

Citations

17
Porous polytrimethylenecarbonate scaffolds: Design considerations and porosity modulation techniques DOI Creative Commons
Klaudia Małgorzata Jurczak, Ruichen Zhang, Wouter L.J. Hinrichs

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113588 - 113588

Published: Jan. 1, 2025

Language: Английский

Citations

3
Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration DOI
Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(29), P. 34570 - 34577

Published: July 11, 2023

The aging population has rapidly driven the demand for bone regeneration. pore structure of a scaffold is critical factor that affects its mechanical strength and Triply periodic minimal surface gyroid structures similar to trabecular are considered superior strut-based lattice (e.g., grids) in terms However, at this stage, only hypothesis not supported by evidence. In study, we experimentally validated comparing grid scaffolds composed carbonate apatite. possessed compressive approximately 1.6-fold higher than because prevented stress concentration, whereas could not. porosity was scaffolds; however, generally have trade-off relationship. Moreover, formed more twice amount as critical-sized defect rabbit femur condyles. This favorable regeneration using attributed high permeability (i.e., larger volume macropores or porosity) curvature profile structure. Thus, study conventional vivo experiments revealed factors led hypothetical outcome. findings expected contribute development can achieve early without sacrificing strength.

Language: Английский

Citations

29
Phospholipid Bilayer Inspired Sandwich Structural Nanofibrous Membrane for Atmospheric Water Harvesting and Selective Release DOI
Zhihua Yu, Shuhui Li, Jichao Zhang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(8), P. 2629 - 2636

Published: Feb. 13, 2024

Atmospheric water harvesting (AWH) has been broadly exploited to meet the challenge of shortage. Despite significant achievements AWH, leakage hydroscopic salt during AWH process hinders its practical applications. Herein, inspired by unique selective permeability phospholipid bilayer, a sandwich structural (hydrophobic–hydrophilic–hydrophobic) polyacrylonitrile nanofibrous membrane (San-PAN) was fabricated for AWH. The hydrophilic inner layer loaded with LiCl could capture from air. hydrophobic microchannels in outer selectively allow free transmission gaseous molecules but confine solution layer, achieving continuous and recyclable sorption/desorption. As demonstrated, as-prepared devices presented high-efficient adsorption kinetics 1.66 4.08 g g–1 at 30% 90% relative humidity. Thus, this work strengthens understanding along provides insight into applications

Language: Английский

Citations

13
Preparation and characterization of a jelly fig (Ficus awkeotsang Makino) polysaccharide-based bioactive 3D scaffold for improved vascularization and skin tissue engineering applications DOI
Thangavel Ponrasu,

Iniyan Saravanakumar,

Manoj Kumar Sundaram

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129199 - 129199

Published: Jan. 3, 2024

Language: Английский

Citations

10
Transformable Carbonate Apatite Chains as a Novel Type of Bone Graft DOI Creative Commons
Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 17, 2024

The aging global population is generating an ever-increasing demand for bone regeneration. Various materials, including blocks, granules, and sponges, are developed However, blocks require troublesome shaping exhibit poor bone-defect conformities; granules migrate into the surrounding tissues during after filling of defect, causing handling difficulties complications; sponges contain polymers that subject to religious restrictions, lack osteoconductivity, may cause inflammation allergies. Herein, carbonate apatite chains overcome limitations conventional materials presented. Although migrate, ectopic calcification, remain in defects without any complications. conform defect shape transform 3D porous structures, resulting faster regeneration than observed using granules. Thus, these findings indicate even traditional calcium phosphates can be converted state-of-the-art via control.

Language: Английский

Citations

10
Understanding the relationship between pore structure and properties of triply periodic minimal surface bone scaffolds DOI Creative Commons

Yadi Sun,

Yan Wang,

Benchao Dong

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 7, 2025

The number of patients with bone defects caused by trauma and diseases has been increasing year year. treatment remains a major challenge in clinical practice. Bone scaffolds are increasingly favored for repairing bones, triply periodic minimal surface (TPMS) emerging as popular option due to their superior performance. aim this review is highlight the crucial influence pore structure on properties TPMS scaffolds, offering important insights innovation production. It briefly examines various elements that such shape, porosity, diameter, curvature. By analyzing these elements, serves valuable reference upcoming research practical implementations field tissue engineering.

Language: Английский

Citations

1
3D-Printed Polyurethane Scaffolds for Bone Tissue Engineering: Techniques and Emerging Applications DOI

Kumari Shanno,

Preeti Mangala,

T. S. Shanmugarajan

et al.

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

Citations

1
Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering DOI Creative Commons
Dhanalakshmi Jeyachandran, Marta Cerruti

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(17)

Published: June 16, 2023

Porosity affects performance of scaffolds for bone tissue engineering both in vitro and vivo. Macropores (i.e., pores with a diameter >100 μm) are essential cellular infiltration; micropores 1–10 promote cell adhesion facilitate nutrient absorption. Scaffolds containing macropores exploit the advantages pore sizes have excellent osteogenic properties. Nanopores 1–50 nm) can be included as well, to improve cell–material interactions by further enhancing surface area scaffold. This article reviews fabrication techniques properties multiscale porosity, focusing on glass, ceramic, polymeric, composite scaffolds. After discussing structure how it inspired engineering, nomenclature is introduced. Then, used induce nature created, effects scaffold porosity mechanical biological activity discussed. The review concludes providing an outlook this field, including advancements that made possible computational modeling artificial intelligence.

Language: Английский

Citations

22