Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 469 - 541
Published: Jan. 1, 2023
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4854 - 4854
Published: Oct. 13, 2024
Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor across varying physiological conditions often leads reduced absorption inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through use nanomaterials magnetic nanoparticles, offers innovative solutions enhance comprehensive focuses on recent advancements approaches nanotechnology. We highlight both successes remaining this field, emphasizing role continued innovation. Future research should prioritize developing universal solutions, conducting interdisciplinary research, leveraging personalized nanomedicine address biological variability.
Language: Английский
Citations
25
Environmental Research, Journal Year: 2023, Volume and Issue: 227, P. 115722 - 115722
Published: March 21, 2023
Language: Английский
Citations
42
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 4, 2023
Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment. However, tumor therapy still faces challenges due to the intrinsic heterogeneity of cancer, genomic instability, formation an immunosuppressive microenvironment. Functional materials possess unique biological properties such as long circulation times, tumor-specific targeting, immunomodulation. The combination functional with natural substances nanotechnology has led development smart biomaterials multiple functions, high biocompatibilities, negligible immunogenicities, which can be used for precise Recently, subcellular structure-targeting received particular attention various biomedical applications including diagnosis, sensing, imaging tumors drug delivery. Subcellular organelle-targeting precisely accumulate therapeutic agents organelles, considerably reduce threshold dosages agents, minimize drug-related side effects. This review provides a systematic comprehensive overview research organelle-targeted based on nanomaterials. Moreover, it explains prospects precision oncology. will serve excellent cutting-edge guide researchers field therapy.
Language: Английский
Citations
21
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based nanoparticles are of constant interest in the scientific community as potential systems for biomedical applications. Over years, ability to synthesize diverse based on iron (II, III) oxide has been mastered maximize their effectiveness targeted delivery active substances cancer therapy. The present review explores recent literature findings that detail various magnetic nanosystems. These encompass straightforward designs featuring a polymer coating core and more intricate matrices delivering chemotherapeutic drugs. This paper emphasizes novel synthetic approaches impact efficacy progress anticancer investigations, specifically targeting particular type. research also delves into combinations with alternative treatment methods diagnostic approaches. Additionally, it highlights critical aspect—the interaction cells—identifying least developed aspect current these systems.
Language: Английский
Citations
8
Food Chemistry, Journal Year: 2023, Volume and Issue: 438, P. 137961 - 137961
Published: Nov. 14, 2023
Language: Английский
Citations
13
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 166, P. 112510 - 112510
Published: May 7, 2024
Language: Английский
Citations
5
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(48), P. 55201 - 55231
Published: Nov. 23, 2023
The nanomaterial and related toolkit have promising applications for improving human health well-being. Nanobased drug delivery systems use nanoscale materials as carriers to deliver therapeutic agents in a targeted controlled manner, they shown potential address issues associated with conventional systems. They offer benefits treating various illnesses by encapsulating or conjugating biological agents, chemotherapeutic drugs, immunotherapeutic agents. of this technology are vast; however, significant challenges exist overcome such safety issues, toxicity, efficacy, insufficient capacity. This article discusses the latest developments systems, including release mechanisms, material toolkits, design molecules, parameters. concluding section examines limitations provides insights into future possibilities.
Language: Английский
Citations
11
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7803 - 7823
Published: Dec. 1, 2023
Abstract: Brain tumors, including primary gliomas and brain metastases, are one of the deadliest tumors because effective macromolecular antitumor drugs cannot easily penetrate blood-brain barrier (BBB) tumor (BTB). Magnetic nanoparticles (MNPs) considered most suitable nanocarriers for delivery their unique properties compared to other nanoparticles. Numerous preclinical clinical studies have demonstrated potential these in magnetic targeting, nuclear resonance, thermal therapy, ultrasonic hyperthermia. To further develop optimize MNPs diagnosis treatment we attempt outline recent advances use deliver drugs, with a particular focus on efficacy anti-brain based targeting low-intensity focused ultrasound, resonance imaging surgical real-time guidance, magnetothermal hyperthermia therapy. Furthermore, summarize findings application research limitations that need be addressed translation. Keywords: nanoparticles, barrier, drug delivery,
Language: Английский
Citations
10
Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1306, P. 342581 - 342581
Published: April 10, 2024
Language: Английский
Citations
4
Nanoscale Advances, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A simple, efficient MW/US-assisted protocol is reported for obtaining MNPs. Amino citrate-modified βCD acts as a flexible amphoteric device developing MNPs in preclinical MRI diagnostic and theranostic applications.
Language: Английский
Citations
3