Advances in Brain Tumor Therapy Based on the Magnetic Nanoparticles

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7803 - 7823

Published: Dec. 1, 2023

Abstract: Brain tumors, including primary gliomas and brain metastases, are one of the deadliest tumors because effective macromolecular antitumor drugs cannot easily penetrate blood-brain barrier (BBB) tumor (BTB). Magnetic nanoparticles (MNPs) considered most suitable nanocarriers for delivery their unique properties compared to other nanoparticles. Numerous preclinical clinical studies have demonstrated potential these in magnetic targeting, nuclear resonance, thermal therapy, ultrasonic hyperthermia. To further develop optimize MNPs diagnosis treatment we attempt outline recent advances use deliver drugs, with a particular focus on efficacy anti-brain based targeting low-intensity focused ultrasound, resonance imaging surgical real-time guidance, magnetothermal hyperthermia therapy. Furthermore, summarize findings application research limitations that need be addressed translation. Keywords: nanoparticles, barrier, drug delivery,

Language: Английский

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NIR-responsive porous gold nanorod dispersed in a 3D gelatin scaffold for stimulus-responsive drug release and synergistic therapy

Materials Advances, Journal Year: 2024, Volume and Issue: 5(17), P. 6853 - 6863

Published: Jan. 1, 2024

Biodegradable porous nanomaterials have emerged as a promising avenue for tumor drug delivery owing to their capacity encapsulate large quantities of drugs and compatibility with biological systems.

Language: Английский

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Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(11)

Published: July 25, 2024

Radiotherapy (RT), which is a therapeutic treatment modality that commonly used for cancer, employs high‐energy irradiation to induce the generation of reactive oxygen species (ROS) and cause DNA damages. Nevertheless, efficacy RT predominantly constrained due inadequate damage in malignancies deleterious impacts on healthy tissues. In current study, bovine serum albumin (BSA)–coated AgBiS 2 nanodots, also known as @ BSA were developed enhanced breast cancer treatment. This was accomplished by use an extremely simple eco‐friendly method. Both scanning transmission electron microscopy (STEM) (SEM) images revealed prepared nanoradiosensitizers, BSA, spherical shape uniformly distributed. nanodots possessed excellent biocompatibility exhibit monodispersity well. Furthermore, vitro assays such MTT, colony formation assay, intracellular ROS assay significant cell inhibitory impact produced under X‐ray irradiation. Remarkably, combined administration along with increased level within cells increasing localized radiation dosage improving anti‐tumor effectiveness RT.

Language: Английский

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Preparation of Hybrid Fe 3 O 4 @SiO 2 Biopolymer Core-Shell Anticancer Drug Carrier for Sustainable Release of Doxorubicin

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Magnetic core-shell drug-carrier microcapsules were prepared and investigated using doxorubicin (Dox) as an anticancer drug model. First, superparamagnetic iron oxide nanoparticles (Fe₃O₄), coated with silica SiO₂ a sol-gel method. Next, the Fe₃O₄@SiO₂ functionalized (3-aminopropyl) ethoxy silane (APS), to obtain Fe₃O₄@SiO₂-NH₂. Afterward, was added form Fe₃O₄@SiO₂-NH₂-(Dox), then wrapped in polymer matrix by adding chitosan/CaCl₂ aqueous solution. The presence of divalent Ca²⁺ cations ensured hydrogel chain reticulation Fe₃O₄@SiO₂-NH₂-(Dox) encapsulation into matrix. chitosan chosen shrink microcapsules' pores limit diffusion acidic pH. Finally, solution dextran polyvinyl pyrrolidone chloroform outermost shell structure. This magnetic microcapsule noted system (A). second (B), obtained shell. two-hybrid core-shell, carriers A, B observed scanning electron microscopy (SEM) characterized ATR-FTIR spectroscopy, their characteristics confirmed. kinetic study revealed that (A) had greater release efficiency than enhanced effect at pH 5.8 7.4 associated cancer cell environments, rather 4.9 healthy environments. Therefore, carrier selected promising candidate for targeting therapy.

Language: Английский

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Therapeutic and Diagnostic Uses of Magnetic Nanoparticles in Cancer

Published: Jan. 1, 2024

Magnetic nanoparticle (MNP)-based technologies are now often used in biological systems for therapeutic or diagnostic applications. Recent developments nanotechnology have led to the creation of MNPs, which appropriate biomedical nanoparticles a class extremely adaptable instruments cancer therapy because their innate magnetic characteristics and multifunctional design. For diagnosis, monitoring, therapy, this category provides multimodal theranostics platform. In terms (MNPs) can be increase sensitivity platforms. with high moments surface-to-volume ratios attractive targeted medication delivery treatment. chapter, recent application MNPs biosensing, drug control, will provided. The field's challenges potential opportunities using enhance properties considered.

Language: Английский

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HMNPs@PDA-GQDs-FA as carries of gambogic acid for inhibiting VX2 tumor cells

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: unknown, P. 129957 - 129957

Published: Sept. 1, 2024

Language: Английский

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pH-responsive Magnetic Nanocarriers for Chelator-free Bimodal (MRI/SPECT-CT) Image Guided Chemo-hyperthermia Therapy in Human Breast Carcinoma

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Development of pH-Responsive magnetic nanocarriers for bimodal (MRI/SPECT-CT) image-guided chemo-thermal therapy in human breast carcinoma.

Language: Английский

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Recent progress and current status of surface engineered magnetic nanostructures in cancer theranostics

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 334, P. 103320 - 103320

Published: Oct. 30, 2024

Language: Английский

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CPP Functionalized Nanoparticles

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 469 - 541

Published: Jan. 1, 2023

Language: Английский

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