Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Abstract
Stimulus-responsive
drug
delivery
systems
based
on
anticancer
of
curcumin
constitute
a
promising
strategy
to
overcome
some
challenges
Lung
cancer
treatment.
In
the
present
study,
pH-responsive
nanocarriers
were
designed
by
sodium
alginate
(SA),
zein,
and
γ-alumina
(γ-Al2O3)
as
nanocarrier
via
W/O/W
double
emulsion
technique
facilitate
targeted
lung
cells.
The
characterize
physical
interactions
crystalline
structure
confirmed
FTIR
XRD,
respectively.
size
drug-loaded
nanocomposites
was
218.6
nm
with
monodisperse
particle
distribution,
having
rod-like
shape
approved
DLS
analysis
FE-SEM,
Sensitivity
samples
pH
studied
using
ultraviolet
−
visible
spectroscopy.
UV
vis
spectroscopy
results
display
higher
absorption
intensities
in
acidic
tumor
conditions
(pH
5.4)
than
physiological
(7.4).
method
significantly
enhanced
loading
entrapment
efficiency
compared
other
reported
systems.
Cytotoxicity
cell
death
further
analyzed
MTT
flow
cytometry
assays.
These
suggest
that
SA/zein/γ-Al2O3
nanocomposite
is
promise
system
for
therapy.
Cancer Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Despite
significant
advancements
in
cancer
treatment,
current
therapies
often
fail
to
completely
eradicate
malignant
cells.
This
shortfall
underscores
the
urgent
need
explore
alternative
approaches
such
as
vaccines.
Leveraging
immune
system's
natural
ability
target
and
kill
cells
holds
great
therapeutic
potential.
However,
development
of
vaccines
is
hindered
by
several
challenges,
including
low
stability,
inadequate
response
activation,
immunosuppressive
tumor
microenvironment,
which
limit
their
efficacy.
Recent
progress
various
fields,
click
chemistry,
nanotechnology,
exosome
engineering,
neoantigen
design,
offer
innovative
solutions
these
challenges.
These
achievements
have
led
emergence
smart
vaccine
platforms
(SVPs),
integrate
protective
carriers
for
messenger
ribonucleic
acid
(mRNA)
with
functionalization
strategies
optimize
targeted
delivery.
Click
chemistry
further
enhances
SVP
performance
improving
encapsulation
mRNA
antigens
facilitating
precise
delivery
review
highlights
latest
developments
technologies
therapy,
exploring
both
opportunities
challenges
advancing
transformative
approaches.
Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 25, 2024
The
genetic
material
within
cells
plays
a
pivotal
role
in
shaping
the
structure
and
function
of
living
organisms.
Manipulating
an
organism's
genome
to
correct
inherited
abnormalities
or
introduce
new
traits
holds
great
promise.
Genetic
engineering
techniques
offers
promising
pathways
for
precisely
altering
cellular
genetics.
Among
these
methodologies,
clustered
regularly
interspaced
short
palindromic
repeat
(CRISPR),
honored
with
2020
Nobel
Prize
Chemistry,
has
garnered
significant
attention
its
precision
editing
genomes.
However,
CRISPR
system
faces
challenges
when
applied
vivo,
including
low
delivery
efficiency,
off-target
effects,
instability.
To
address
challenges,
innovative
technologies
targeted
precise
have
emerged.
Engineered
carrier
platforms
represent
substantial
advancement,
improving
stability,
precision,
reducing
side
effects
associated
editing.
These
facilitate
efficient
local
systemic
various
tissues
cells,
immune
cells.
This
review
explores
recent
advances,
benefits,
CRISPR-based
delivery.
It
examines
carriers
nanocarriers
(polymeric,
lipid-derived,
metallic,
bionanoparticles),
viral
particles,
virus-like
exosomes,
providing
insights
into
their
clinical
utility
future
prospects.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3133 - 3133
Published: July 23, 2023
Curcumin
(CUR)
has
potent
anticancer
activities,
and
its
bioformulations,
including
biodegradable
polymers,
are
increasingly
able
to
improve
CUR’s
solubility,
stability,
delivery
cancer
cells.
In
this
study,
copolymers
comprising
poly
(L-lactide)-poly
(ethylene
glycol)-poly
(L-lactide)
(PLA-PEG-PLA)
glycol)
(PEG-PLA-PEG)
were
designed
synthesized
assess
compare
their
CUR-delivery
capacity
inhibitory
potency
on
MCF-7
breast
Molecular
dynamics
simulations
free
energy
analysis
indicated
that
PLA-PEG-PLA
a
higher
propensity
interact
with
the
cell
membrane
more
negative
energy,
suggesting
it
is
better
carrier
for
penetration.
To
characterize
copolymer
synthesis,
Fourier
transform-infrared
(FT-IR)
proton
nuclear
magnetic
resonance
(1H-NMR)
employed,
size
was
measured
using
dynamic
light
scattering
(DLS),
surface
charge
determined
by
zeta
potential
analysis.
Characterization
ring-opening
polymerization
(ROP)
reaction
optimal
synthesizing
high-quality
polymers.
Microspheres
then
successfully.
Of
two
formulations,
experimentally
exhibited
results,
an
initial
burst
release
of
17.5%,
followed
slow,
constant
encapsulated
drug
up
80%.
PLA-PEG-PLA-CUR
showed
significant
increase
in
death
cells
(IC50
=
23.01
±
0.85
µM)
based
MTT
assay.
These
data
consistent
gene
expression
studies
Bax,
Bcl2,
hTERT,
which
induced
apoptosis
efficiently
these
Through
integration
nano-informatics
vitro
approaches,
our
study
system
delivering
curcumin
inhibit
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(3), P. 221 - 221
Published: Jan. 30, 2025
Phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
emerged
as
a
promising
non-invasive
cancer
treatment,
addressing
issues
like
drug
resistance
systemic
toxicity
common
in
conventional
breast
therapies.
Recent
research
shown
that
copper
sulphide
(CuS)
nanoparticles
polydopamine
(PDA)
exhibit
exceptional
conversion
efficiency
under
808
nm
near-infrared
(NIR)
laser
irradiation,
making
them
valuable
for
phototherapy.
However,
the
effectiveness
of
PDT
is
limited
hypoxic
tumour
environments,
which
are
many
types,
due
to
its
reliance
on
local
oxygen
levels.
Moreover,
single-modality
approaches,
phototherapy,
often
prove
insufficient
complete
elimination,
despite
their
therapeutic
strength.
In
this
paper,
microfluidic-assisted
approach
was
used
create
multifunctional
silk-based
(SFNPs)
encapsulating
chemotherapeutic
Epirubicin
(EPI),
PTT/PDT
agent
CuS,
heat-activated,
oxygen-independent
alkyl
radical
generator
AIPH
combined
chemotherapy,
PTT,
PDT,
with
coating
enhanced
effects
surface-bound
folic
acid
(FA)
targeted
delivery
treatment.
The
synthesised
CuS-EPI-AIPH@SF-PDA-FA
achieved
controlled
size
378
nm,
strong
NIR
absorption,
high
efficiency.
Under
these
selectively
triggered
release
radicals
EPI,
improving
intracellular
levels
effectively
killing
various
cell
lines
while
demonstrating
low
non-cancerous
cells.
We
demonstrate
novel
core–shell
NPs
have
been
successfully
designed
nanoplatform
integrating
chemotherapy
targeted,
synergistic
European Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107103 - 107103
Published: April 1, 2025
Treating
a
chronic
condition
such
as
breast
cancer
usually
requires
daily
oral
drug
administration
for
extended
periods
of
time,
which
is
associated
with
non-adherence
to
the
prescribed
therapy
that
may
cause
disease
progression.
New
delivery
strategies
long-acting
injectable
(LAI)
implants
have
entered
picture
in
order
solve
drawbacks
while
improving
bioavailability,
plasma
levels
variability
or
treatment
compliance.
This
has
motivated
development
new
polymeric
and
biodegradable
situ
forming
implant
letrozole.
formulation
provided
kit
two
syringes
(one
them
containing
letrozole
Poly-Lactic
Acid,
other
one
dimethyl
sulfoxide
solvent
reconstitution).
Once
reconstituted
injected
into
muscle,
diffuses
tissue
fluids
insoluble
polymer
precipitates,
semi-solid
traps
API
allows
sustained
release.
In
optimize
both
process,
traditional
vitro
dissolution
assessment
predictive
modelling
were
conducted
identify
characteristics
show
an
impact
on
kinetics
release,
provide
first
basis
potentially
establish
vitro-in
vivo
correlation
(IVIVC)
pre-clinical
clinical
data
future.
Two
methods
(real-time
accelerated)
used
describe
profiles
15
LAI
formulations
differing
their
Critical
Material
Attributes
(CMAs).
The
release
best
described
using
Weibull
distribution
estimating
fraction
dose
loss
during
injection.
rate
constant
(KD)
was
increased
by
1.87
times
case
accelerated
conditions,
30%
reduced
1.34
high
low
viscosity
formulations,
respectively.
work
allowed
quantitative
characterization
related
responsible
controlling
It
provides
understanding
will
serve
guide
robust
product
quality
control
specifications.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 18, 2025
Abstract
The
development
of
biodegradable
nanoparticles
(NPs)
for
delivering
anticancer
drugs,
such
as
letrozole
(LTZ),
offers
a
targeted
approach
cancer
therapy.
In
this
study,
we
synthesized
poly(ε‐caprolactone)‐
co
‐poly(ethylene
glycol)
(PCL‐
‐PEG)
and
fabricated
LTZ‐loaded
PCL‐
‐PEG
NPs
(LTZ‐NPs)
via
emulsion‐solvent
evaporation.
Folic
acid
(FA),
folate
receptor‐targeting
molecule,
was
conjugated
to
the
(LTZ‐FNPs)
enhance
treatment
efficacy
against
hormone
receptor‐positive
breast
cells.
Both
FNPs
exhibited
spherical
morphology
(60–90
nm),
with
showing
higher
drug
entrapment
efficiency
controlled
release.
LTZ
release
minimal
at
physiological
pH
but
increased
in
acidic,
cancer‐like
environments,
following
Korsmeyer‐Peppas
model,
indicating
combination
Fickian
non‐Fickian
diffusion.
cytotoxicity
assays,
LTZ‐FNPs
toxicity
MCF‐7
cells
than
LTZ‐NPs.
Controlled
altered
gene
expression,
reducing
B‐cell
leukemia/lymphoma
2
protein
(Bcl2)
increasing
caspase
8
(Casp8),
promoting
apoptosis.
A
shift
SubG1
phase
further
confirmed
enhanced
LTZ‐FNP‐mediated
cell
death.
Furthermore,
p53
expression
increased,
while
matrix
metalloproteinase
9
(MMP‐9)
decreased,
inhibiting
invasion.
This
study
introduces
system
FA‐functionalized,
pH‐sensitive
delivery
LTZ.
holds
great
potential
selective,
efficient
minimizing
systemic
