Lipid Nanocarriers as Precision Delivery Systems for Brain Tumors
Roshan Keshari,
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Mahima Dewani,
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Navneet Kaur
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et al.
Bioconjugate Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Brain
tumors,
particularly
glioblastomas,
represent
the
most
complicated
cancers
to
treat
and
manage
due
their
highly
invasive
nature
protective
barriers
of
brain,
including
blood-brain
barrier
(BBB).
The
efficacy
currently
available
treatments,
viz.,
radiotherapy,
chemotherapy,
immunotherapy,
are
frequently
limited
by
major
side
effects,
drug
resistance,
restricted
penetration
into
brain.
Lipid
nanoparticles
(LNPs)
have
emerged
as
a
promising
targeted
delivery
system
for
brain
tumors.
nanocarriers
gained
tremendous
attention
tumor
therapeutics
multiple
encapsulation
abilities,
controlled
release,
better
biocompatibility,
ability
cross
BBB.
Herein,
detailed
analysis
design,
mechanisms,
therapeutic
benefits
LNPs
in
treatment
is
discussed.
Moreover,
we
also
discuss
safety
issues
clinical
developments
current
future
challenges.
Further,
focused
on
transformation
therapy
eliminating
effects
engineering
overcome
related
biological
barriers,
which
provide
personalized,
affordable,
low-risk
options.
Language: Английский
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(10), P. 1479 - 1490
Published: Oct. 2, 2024
Nanoparticles
(NPs)
are
widely
used
in
the
pharmaceutical
field
to
treat
various
human
disorders.
Among
these,
lipid-based
NPs
(LNPs),
including
solid
lipid
nanoparticles
(SLN)
and
nanostructured
carriers
(NLC),
favored
for
drug/bioactive
delivery
due
their
high
stability,
biocompatibility,
encapsulation
efficiency,
sustained/controlled
release.
These
properties
make
them
particularly
suitable
as
of
compounds
derived
from
plant
sources.
Language: Английский
The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
Ronny Vargas,
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Catalina Lizano-Barrantes,
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Miquel Romero-Obón
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et al.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 124686 - 124686
Published: Sept. 1, 2024
The
Blood-Brain
Barrier
(BBB)
significantly
impedes
drug
delivery
to
the
central
nervous
system.
Nanotechnology,
especially
surface-functionalized
lipid
nanoparticles,
offers
innovative
approaches
overcome
this
barrier.
However,
choosing
an
effective
functionalization
strategy
is
challenging
due
lack
of
detailed
comparative
analysis
in
current
literature.
Our
systematic
review
examined
various
strategies
and
their
impact
on
BBB
permeability
from
2041
identified
articles,
which
80
were
included
for
data
extraction.
Peptides
most
common
modification
(18)
followed
by
mixed
(12)
proteins
(9),
antibodies
(7),
other
(8).
Interestingly,
26
studies
showed
penetration
with
unmodified
or
modified
nanoparticles
using
commonly
applied
such
as
PEGylation
surfactant
addition.
Statistical
across
42
correlation
between
higher
vivo
permeation
improvements
nanoparticle
type,
size,
category.
highest
ratios
found
nanostructured
carriers
biomimetic
systems,
particle
sizes
under
150
nm,
those
applying
strategies.
interstudy
heterogeneity
we
observed
highlights
importance
adopting
standardized
evaluation
protocols
enhance
comparability.
aims
provide
a
insight
identify
future
research
directions
development
more
systems
brain
help
improve
treatment
neurological
psychiatric
disorders
tumours.
Language: Английский
Photoresponsive prodrug-based liposomes for controllable release of anticancer drug chlorambucil
Xiaoting Wang,
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Guangtian Suo,
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Shinan Ma
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et al.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
on-demand
delivery
and
release
of
chemotherapeutic
drugs
have
attracted
great
attention,
among
which
photoresponsive
prodrug
systems
shown
specific
advantages
for
effective
cancer
treatment
due
to
their
spatiotemporal
control,
non-invasive
nature
easy
operation.
Unlike
the
traditional
strategy
physical
encapsulation
in
liposomes,
we
herein
report
a
biomimetic
drug
system
(DDS)
based
on
lipid
liposomal
formulation
(LNC),
combines
features
nanomedicines,
can
realize
photocontrollable
anticancer
drugs.
comprises
three
functional
moieties:
single-arm
phospholipid
(Lyso
PC),
an
Language: Английский
Liposomal Encapsulation of Chlorambucil with a Terpyridine-Based, Glutathione-Targeted Optical Probe Facilitates Cell Entry and Cancer Cell Death
Mallayasamy Siva,
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Kiran Das,
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Priya Rana
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et al.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
The
nitrogen
mustard
alkylating
agent
chlorambucil
(CBL)
is
a
critical
component
of
chemotherapeutic
regimens
used
in
the
treatment
chronic
lymphocytic
leukemia.
cancer
cell-killing
actions
CBL
are
limited
by
glutathione
(GSH)
conjugation,
process
catalyzed
GSH
transferase
hGSTA1-1
that
triggers
efflux
from
cells.
In
cell
microenvironment,
intracellular
levels
elevated
to
counterbalance
oxidative
stress
generated
due
high
glycolytic
demand.
As
many
drugs
trigger
death
through
mechanisms
depend
on
reactive
oxygen
species
(ROS),
antioxidant
capacity
cells
also
represents
barrier
anticancer
therapies.
Here,
we
demonstrate
heightened
content
can
be
exploited
for
cell-selective
drug
delivery.
We
successfully
synthesized
malononitrile
conjugate
terpyridine-based
derivative
Language: Английский