ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(9), P. 5513 - 5536
Published: Aug. 22, 2024
Irreversible
bone
defects
resulting
from
trauma,
infection,
and
degenerative
illnesses
have
emerged
as
a
significant
health
concern.
Structurally
functionally
controllable
hydrogels
made
by
tissue
engineering
(BTE)
become
promising
biomaterials.
Natural
proteins
are
able
to
establish
connections
with
autologous
through
unique
biologically
active
regions.
Hydrogels
based
on
can
simulate
the
microenvironment
regulate
biological
behavior
of
stem
cells
in
niche,
making
them
candidates
for
research
related
regeneration.
This
article
reviews
functions
various
natural
macromolecular
(such
collagen,
gelatin,
fibrin,
silk
fibroin)
highlights
their
special
advantages
hydrogels.
Then
latest
trends
cross-linking
modified
protein
improved
mechanical
properties
composite
loaded
exogenous
micromolecular
been
discussed.
Finally,
applications
hydrogels,
such
3D
printed
microspheres,
injectable
were
introduced,
aiming
provide
reference
repair
clinical
defects.
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(10), P. 105968 - 105968
Published: Aug. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
ABSTRACT
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
trauma,
surgical
resection,
degenerative
diseases,
congenital
malformations
are
major
clinical
challenges.
Bone
tissue
engineering
has
significant
advantages
in
the
treatment
severe
defects.
Vascularized
scaffolds
gradually
attracting
attention
development
because
their
excellent
biomimetic
properties
efficient
efficiency.
Three‐dimensional
(3D)
printing
technology,
which
can
be
used
to
fabricate
structures
at
different
scales
using
a
wide
range
materials,
been
production
vascularized
scaffolds.
This
review
discusses
research
progress
3D
for
Angiogenesis‐osteogenesis
coupling
regeneration
process
is
first
introduced,
followed
by
summary
technologies,
inks,
bioactive
factors
Notably,
this
focuses
on
structural
design
strategies
Finally,
application
medicine,
as
well
challenges
outlooks
future
development,
described.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 88 - 88
Published: Jan. 23, 2025
There
is
ongoing
research
for
biomedical
applications
of
polyvinyl
alcohol
(PVA)-based
hydrogels;
however,
the
execution
this
has
not
yet
been
achieved
at
an
appropriate
level
commercialization.
Advanced
perception
necessary
design
and
synthesis
suitable
materials,
such
as
PVA-based
hydrogel
applications.
Among
polymers,
drawn
great
interest
in
owing
to
their
attractive
potential
with
characteristics
good
biocompatibility,
mechanical
strength,
apposite
water
content.
By
designing
approach
investigating
structure,
hydrogels
can
attain
superb
cytocompatibility,
flexibility,
antimicrobial
activities,
signifying
that
it
a
candidate
tissue
engineering
regenerative
medicine,
drug
delivery,
wound
dressing,
contact
lenses,
other
fields.
In
review,
we
highlight
current
progresses
on
explaining
diverse
usage
across
variety
areas.
We
explain
numerous
techniques
related
phenomena
based
these
materials.
This
review
may
stipulate
wide
reference
future
acumens
materials
extensive
Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3303 - 3303
Published: Nov. 26, 2024
Polymers
have
become
essential
in
advancing
bone
tissue
engineering,
providing
adaptable
healing
and
regeneration
solutions.
Their
biocompatibility
biodegradability
make
them
ideal
candidates
for
creating
scaffolds
that
mimic
the
body’s
natural
extracellular
matrix
(ECM).
However,
significant
challenges
remain,
including
degradation
by-products,
insufficient
mechanical
strength,
suboptimal
cellular
interactions.
This
article
addresses
these
by
evaluating
performance
of
polymers
like
poly(lactic-co-glycolic
acid)
(PLGA),
polycaprolactone
(PCL),
polylactic
acid
(PLA)
scaffold
development.
It
also
explores
recent
innovations,
such
as
intelligent
polymers,
bioprinting,
integration
bioactive
molecules
to
enhance
efficacy.
We
propose
overcoming
current
limitations
requires
a
combination
novel
biomaterials,
advanced
fabrication
techniques,
tailored
regulatory
strategies.
The
future
potential
polymer-based
personalised
regenerative
medicine
is
discussed,
focusing
on
their
clinical
applicability.
Virtual and Physical Prototyping,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 18, 2024
Hydroxyapatite
(HA)
is
widely
used
in
bone
scaffold
development,
but
still
faces
problems
of
forming
difficulty,
slow
degradation,
and
limited
biological
performance.
In
this
study,
triply
periodic
minimal
surface
(TPMS)
porous
HA
scaffolds
were
prepared
using
desktop-level
DLP
then
doped
with
bredigite
(BR)
to
enhance
their
performance
through
ion
substitution
adjust
microstructure.
The
DLP-prepared
displayed
intricate
curved
structure,
micro-porosity
decreased
while
grain
size
increased
sintering
holding
time.
During
sintering,
Mg2+
from
BR
substituted
Ca2+
HA,
new
secondary
phases,
which
slightly
significantly
micro-porosity.
These
factors
reduced
mechanical
properties
enhanced
degradation.
rapid
release
inorganic
active
ions
phases
the
biomineralization
cell
response.
This
study
demonstrated
potential
construct
complex
ceramic
modulate
microstructure
