Advanced Functional Materials,
Journal Year:
2019,
Volume and Issue:
29(32)
Published: June 7, 2019
Abstract
A
dual‐functional
photosensitizer
that
demonstrates
exceptional
photodynamic
therapy
(PDT)
efficacy
while
simultaneously
self‐monitoring
the
therapeutic
response
in
real
time
is
reported
here.
Possessing
an
ultrahigh
1
O
2
quantum
yield
of
98.6%
water,
TPCI
can
efficiently
induce
cell
death
a
series
carcinoma
cells
(IC
50
values
less
than
300
×
10
−9
m
)
upon
irradiation
with
extremely
low
fluence
(460
nm,
4
mW
cm
−2
for
min).
In
addition,
self‐monitor
time.
It
weakly
fluorescent
living
before
and
lights
up
nuclei
concomitantly
during
PDT
treatment
by
binding
chromatin
to
activate
its
aggregation‐induced
emission,
attributed
strong
affinity
DNA.
vivo
studies
using
mouse
models
bearing
H22
B16F10
tumor
validate
ultraefficient
as
well
precise
real‐time
noninvasive
readout
from
beginning
cancer
treatment.
The
serves
excellent
candidate
single‐agent
theranostics,
this
work
represents
new
paradigm
development
molecules
multiple
intrinsic
functions
future
self‐reporting
medical
applications.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(25), P. 9888 - 9907
Published: Feb. 12, 2020
Aggregation-induced
emission
(AIE)
describes
a
photophysical
phenomenon
in
which
molecular
aggregates
exhibit
stronger
than
the
single
molecules.
Over
course
of
last
20
years,
AIE
research
has
made
great
strides
material
development,
mechanistic
study
and
high-tech
applications.
The
achievements
demonstrate
that
show
many
properties
functions
are
absent
species.
In
this
review,
we
summarize
advances
field
its
related
areas.
We
specifically
focus
on
new
materials
attained
by
beyond
microscopic
level.
hope
review
will
inspire
more
into
ensembles
at
meso
level
lead
to
significant
progress
biological
science.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(4), P. 1144 - 1172
Published: Jan. 1, 2020
This
review
presents
comprehensive
discussions
on
the
recent
development
in
supramolecular
materials
based
luminogens
with
aggregation-induced
emission
(AIE)
characteristics.
Aggregate,
Journal Year:
2020,
Volume and Issue:
1(1), P. 80 - 106
Published: Dec. 1, 2020
Abstract
Theranostics
referring
to
the
ingenious
integration
of
diagnostics
and
therapeutics
has
garnered
tremendous
attention
in
these
years
as
it
provides
a
promising
opportunity
for
modern
personalized
precision
medicine.
By
virtue
good
biocompatibility,
outstanding
fluorescence
property,
easy
processability
functionalization,
promoted
photosensitizing
efficiency,
well
facile
construction
multi‐modality
theranostics,
fluorophores
with
aggregation‐induced
emission
(AIE)
characteristics
exhibit
inexhaustible
vigorous
vitality
field
theranostics.
Numerous
significant
breakthroughs
state‐of‐the‐art
progression
have
been
witnessed
past
few
years.
This
review
highlights
aggregation‐enhanced
superiorities
AIE
luminogens
(AIEgens)
disease
theranostics
mainly
involving
diagnostic
imaging
(fluorescence
room
temperature
phosphorescence),
therapeutic
intervention
(photodynamic
therapy),
feasibility
based
on
experimental
measurements
theoretical
simulations.
Additionally,
latest
advanced
developments
AIEgens
aspect
corresponding
strategies
design
highly
effective
AIE‐active
through
triggering
aggregation
formation
are
comprehensively
summarized.
Moreover,
brief
conclusion
discussion
current
challenges
future
perspectives
this
area
is
further
presented.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(36)
Published: July 30, 2020
Abstract
Molecular
science
entails
the
study
of
structures
and
properties
materials
at
level
single
molecules
or
small
interacting
complexes
molecules.
Moving
beyond
well‐defined
complexes,
aggregates
(i.e.,
irregular
clusters
many
molecules)
serve
as
a
particularly
useful
form
that
often
display
modified
wholly
new
compared
to
their
molecular
components.
Some
unique
phenomena
such
polymorphic
aggregates,
aggregation‐induced
symmetry
breaking,
cluster
excitons
are
only
identified
in
few
examples
exotic
features.
Here,
by
virtue
flourishing
research
on
emission,
concept
“aggregate
science”
is
put
forward
fill
gaps
between
aggregates.
Structures
aggregate
scale
also
systematically
summarized.
The
structure–property
relationships
established
for
expected
contribute
technological
development.
Ultimately,
may
become
an
interdisciplinary
field
serves
general
platform
academic
research.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(10), P. 3406 - 3426
Published: Jan. 1, 2021
Small-molecule
based
fluorescent
probes
are
increasingly
important
for
the
detection
and
imaging
of
biological
signaling
molecules
due
to
their
simplicity,
high
selectivity
sensitivity,
whilst
being
non-invasive,
suitable
real-time
analysis
living
systems.
With
this
perspective
we
highlight
sensing
mechanisms
including
Förster
resonance
energy
transfer
(FRET),
intramolecular
charge
(ICT),
photoinduced
electron
(PeT),
excited
state
proton
(ESIPT),
aggregation
induced
emission
(AIE)
multiple
modality
fluorescence
approaches
dual/triple
(DSM
or
TSM).
Throughout
remaining
challenges
suggest
potential
directions
development
towards
improved
small-molecule
biosensing.
Aggregate,
Journal Year:
2021,
Volume and Issue:
2(1), P. 95 - 113
Published: Jan. 22, 2021
Abstract
Phototheranostics
that
concurrently
and
complementarily
integrate
real‐time
diagnosis
in
situ
therapeutic
capabilities
one
platform
has
become
the
advancing
edge
of
precision
medicine.
Organic
agents
possess
merits
facile
preparation,
high
purity,
tunable
photophysical
property,
good
biocompatibility,
potential
biodegradability,
which
have
shown
great
promise
for
disease
theranostics.
This
review
summarizes
recent
achievements
organic
phototheranostic
applications,
especially
rationally
utilize
energy
dissipation
pathways
Jablonski
diagram
to
modulate
fluorescence
emission,
photoacoustic/photothermal
production,
photodynamic
processes.
Of
particular
interest
are
systems
exhibiting
huge
differences
aggregate
state
as
compared
with
solution
or
single
molecule
form,
during
intramolecular
motions
play
an
important
role
regulating
properties.
The
advances
from
such
aspect
biomedical
applications
including
high‐resolution
imaging,
activatable
imaging
therapy,
adaptive
theranostics,
image‐guided
surgery,
immunotherapy,
afterglow
discussed.
A
brief
summary
perspective
this
field
also
presented.
We
hope
will
be
helpful
researchers
interested
bioprobe
design
theranostic
inspire
new
insights
into
linkage
between
science
field.
Advanced Functional Materials,
Journal Year:
2019,
Volume and Issue:
30(7)
Published: Dec. 18, 2019
Abstract
The
shortage
of
high
quantum
yield
(QY)
organic
fluorophores
in
the
second
near‐infrared
window
(NIR‐II)
has
become
a
bottleneck
bioimaging
field.
Now,
simple
strategy
is
proposed
to
address
this:
constitutional
isomerization
on
basis
molecular
design
philosophy
aggregation‐induced
emission.
With
combination
backbone
distortion
and
rotor
twisting,
resultant
NIR‐II
fluorophore
2TT‐
o
C6B
displays
an
emission
peak
at
1030
nm
QY
11%
nanoparticles,
one
highest
reported
so
far.
Control
molecules
confirm
that
distorted
twisted
rotors
play
equally
important
roles
determining
fluorescence
properties
fluorophores.
To
allow
for
targeting
ability
reach
deeply
located
diseases,
neutrophils
(NEs)
are
used
penetrate
brain
tissues
accumulate
inflammation
site.
Herein,
it
shown
NEs
carrying
nanoparticles
can
blood‐brain‐barrier
visualize
through
intact
scalp
skull.
Notably,
bright
contributes
significantly
enhanced
signal‐to‐background
ratio
30.6
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(12), P. 3981 - 4042
Published: Jan. 1, 2020
Conjugated
porous
polymers
(CPPs)
are
a
class
of
amorphous
polymer
networks
that
are,
in
their
design,
fully
cross-linked
and
π-conjugated.
The
nature
CPPs
means
they
have
permanent
intrinsic
porosity
(on
the
nanometer
scale),
which,
combination
with
π-conjugated
framework,
makes
these
materials
unique
among
wider
polymeric
materials.
In
recent
years,
need
for
new
efficient
functional
has
driven
development
as
versatile
platforms
applications
including
(photo)catalysis,
light
harvesting,
gas
separation
storage,
chemosensing,
environmental
remediation
energy
storage.
efficiency
towards
described
is
heavily
influenced
by
choice
molecular
building
blocks
synthetic
conditions,
allowing
facile
tailoring
optimisation
structure
properties.
aim
this
review
to
highlight
select
works
on
CPPs,
basic
structural
design
principles,
various
protocols
topical
