Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

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The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

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Organic molecular aggregates: From aggregation structure to emission property

Aggregate, Journal Year: 2021, Volume and Issue: 2(4)

Published: June 24, 2021

Abstract Organic molecular aggregates have attracted widespread attention over the past decade owing to their unique optoelectronic properties in aggregate state, which mainly involves effects of aggregation structure as well packing mode. Although many examples H‐ and J‐aggregates defined by exciton model been found, there are also other types unconventional aggregates, especially for aggregation‐induced emission (AIE) system. In this review, recent progress some basic novel forms, coassembled presenting distinctive optical features, such waveguide polarization emission, polymorph‐dependent stimuli‐responsive luminescence presented. The systematic insight into relationship between property is discussed. Guidelines therefore anticipated will direct future preprogramming design so fine‐tune feature through a specific developing organic with desirable properties.

Language: Английский

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Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(33), P. 15391 - 15402

Published: Aug. 10, 2022

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its derivative (TPEO-BBT) by changing electron-donating triphenylamine unit tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative of 31.5% 23.9% water, respectively. By an integrating sphere, absolute was measured be 1.8% water. Its crystals showed 10.4%, which highest value among organic small molecules reported so far. optimized D–A interaction higher rigidity state are believed two key factors QY. Finally, photoluminescence (PL) chemiluminescence (CL) bioimaging through successive CL resonance energy transfer Förster processes. realized excellent PL quality mouse blood vessels local arthrosis inflammation mice signal-to-background ratio 130. Thus, design presented here brings new possibilities development bright technologies.

Language: Английский

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Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Aggregate, Journal Year: 2021, Volume and Issue: 2(4)

Published: May 7, 2021

Abstract Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, they have received more attention in recent years. Excellent activatable AIE probes been reported detecting toxic substances, imaging intracellular active molecules/biomolecules, as well monitoring the activity of overexpressed enzymes cancers. Moreover, majority theranostic can be specifically triggered cancer cells kill these under light irradiation, while no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to traditional chemotherapy. Thus, this review, we systematically summarized development bioprobes years from molecular design principles biological applications. The challenges corresponding solutions are described. We hope information provided review will facilitate promote practical application AIEgens.

Language: Английский

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Good Steel Used in the Blade: Well‐Tailored Type‐I Photosensitizers with Aggregation‐Induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(14)

Published: May 21, 2021

Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration distinctive strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, precise nuclear targeting protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics fabricated first time. Of two synthesized AIE PSs, TTFMN demonstrated exhibit superior property stronger reactive species (ROS) generation efficiency owing introduction tetraphenylethylene smaller singlet-triplet energy gap, respectively. With aid lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k-poly(ethylene glycol)5k-succinic anhydride-modified TAT, corresponding TTFMN-loaded nanoparticles accompanied acid-triggered peculiarity can quickly accumulate tumor site, effectively generate ROS region suppress growth under white light irradiation minimized systematic toxicity. This delicate "Good Steel Used Blade" tactic maximizes efficacy offers conceptual while practical paradigm optimized treatment further translational medicine.

Language: Английский

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Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 21, 2022

Abstract Golgi apparatus (GA) oxidative stress induced by in situ reactive oxygen species (ROS) could severely damage the morphology and function of GA, which may open up an avenue for effective photodynamic therapy (PDT). However, due to lack design strategy, photosensitizers (PSs) with specific GA targeting ability are high demand yet quite challenging. Herein, we report aggregation-induced emission luminogen (AIEgen) based PS (TPE-PyT-CPS) that can effectively target via caveolin/raft mediated endocytosis a Pearson correlation coefficient 0.98. Additionally, introduction pyrene into TPE-PyT-CPS reduce energy gap between lowest singlet state (S 1 ) triplet (T (Δ E ST exhibits enhanced generation capability. fragmentation cleavage proteins (p115/GM130) observed upon light irradiation. Meanwhile, apoptotic pathway is activated through crosstalk mitochondria HeLa cells. More importantly, TPE-T-CPS show better PDT effect than its non-GA-targeting counterpart TPE-PyT-PS, even though they possess very close ROS rate. This work provides strategy development PSs ability, great importance precise PDT.

Language: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: March 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Language: Английский

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Donor/π‐Bridge Manipulation for Constructing a Stable NIR‐II Aggregation‐Induced Emission Luminogen with Balanced Phototheranostic Performance**

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(51), P. 26769 - 26776

Published: Oct. 9, 2021

Abstract Owing to their versatile functionality and tunable energy dissipation, aggregation‐induced emission luminogens (AIEgens) have emerged as a potential platform for multimodal theranostics. Nevertheless, the construction of AIE‐active phototheranostic agents in second near‐infrared window (NIR‐II, 1000–1700 nm), which allows superior resolution minimized photodamage, is still formidable challenge. Herein, benzo[ c ]thiophene serves an electron‐rich bulky donor (D)/π‐bridge, can enlarge conjugation length distort backbone AIEgen. By precise D/π‐bridge engineering, highly stable NIR‐II AIEgen DPBTA‐DPTQ nanoparticles are obtained with acceptable fluorescence quantum yield excellent photothermal conversion efficiency. In addition, spatial conformation determined first time by X‐ray single crystal diffraction theoretical simulations. NPs good biocompatibility show efficient therapeutic effects vitro tests. Furthermore, were used fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided eradication tumors HepG2 B16‐F10 tumor‐xenografted mice.

Language: Английский

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A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(35), P. 14147 - 14157

Published: July 21, 2021

Sensing temperature at the subcellular level is of great importance for understanding miscellaneous biological processes. However, development sensitive and reliable organic fluorescent nanothermometers remains challenging. In this study, we report fabrication a novel nanothermometer study its application in sensing. First all, synthesize dual-responsive luminogen that can respond to molecular state aggregation environmental polarity. Next, natural saturated fatty acids with sharp melting points as well reversible rapid phase transition are employed encapsulation matrix correlate external heat information fluorescence properties luminogen. To apply composite materials application, formulate them into colloidally dispersed nanoparticles by technique combines situ surface polymerization nanoprecipitation. As anticipated, resultant zwitterionic exhibits sensitive, reversible, reliable, multiparametric responses variation within narrow range around physiological (i.e., 37 °C). Taking spectral position, intensity, lifetime correlation parameters, maximum relative thermal sensitivities determined be 2.15% °C–1, 17.06% 17.72% respectively, which much higher than most nanothermometers. Furthermore, achieve multimodal sensing bacterial biofilms using these three complementary parameters. Besides, also fabricate cationic form facilitate efficient cellular uptake, holding promise studying behaviors systems.

Language: Английский

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