ACS Applied Bio Materials,
Journal Year:
2022,
Volume and Issue:
5(9), P. 4055 - 4085
Published: Aug. 18, 2022
Currently,
the
clinic's
treatment
of
acute/chronic
wounds
is
still
unsatisfactory
due
to
lack
functional
and
appropriate
wound
dressings.
Intelligent
multifunctional
dressings
are
considered
most
advanced
modalities.
It
essential
design
develop
with
required
functions
according
microenvironment
in
clinical
treatment.
This
work
summarizes
characteristics
various
common
wounds,
such
as
acute
wound,
diabetic
burns
scalded
mucosal
ulcers
wound.
Furthermore,
factors
transformation
from
chronic
were
analyzed.
Then
we
focused
on
summarizing
how
researchers
fully
thoroughly
combined
complex
modern
technology
ensure
usability
value
dressing,
photothermal-sensitive
dressings,
dressing
(pH-sensitive
ROS-sensitive
osmotic
pressure
dressings),
hemostatic
guiding
tissue
regeneration
microneedle
3D/4D
printing
Finally,
revolutionary
development
transform
existing
into
needs
soon
possible
have
carried
out
a
reasonable
meaningful
outlook.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(12), P. 18895 - 18930
Published: Dec. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(30)
Published: Aug. 26, 2023
Nitric
oxide
(NO)
is
a
gaseous
molecule
that
has
central
role
in
signaling
pathways
involved
numerous
physiological
processes
(e.g.,
vasodilation,
neurotransmission,
inflammation,
apoptosis,
and
tumor
growth).
Due
to
its
form,
NO
short
half-life,
physiology
concentration
dependent,
often
restricting
function
target
site.
Providing
from
an
external
source
beneficial
promoting
cellular
functions
treatment
of
different
pathological
conditions.
Hence,
the
multifaceted
pathology
garnered
massive
interest
developing
strategies
deliver
exogenous
for
various
regenerative
biomedical
complexities.
NO-releasing
platforms
or
donors
capable
delivering
controlled
sustained
manner
tissues
organs
have
advanced
past
few
decades.
This
review
article
discusses
detail
generation
via
enzymatic
synthase
as
well
multiple
biological
modulates.
The
methods
incorporating
into
diverse
biomaterials
including
physical,
chemical,
supramolecular
techniques
are
summarized.
Then,
these
highlighted
terms
advancing
medical
problems.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
6(9), P. 2647 - 2657
Published: Feb. 15, 2021
Most
commonly
used
wound
dressings
have
severe
problems,
such
as
an
inability
to
adapt
shape
or
a
lack
of
antibacterial
capacity,
affecting
their
ability
meet
the
requirements
clinical
applications.
Here,
nanocomposite
hydrogel
(XKP)
is
developed
by
introducing
polydopamine
nanoparticles
(PDA
NPs)
into
food
gum
matrix
(XK,
consisting
xanthan
and
konjac
glucomannan,
both
FDA-approved
thickening
agents)
for
skin
healing.
In
this
system,
embedded
PDA
NPs
not
only
interact
with
form
excellent
mechanical
strength,
but
also
act
photothermal
transduction
agents
convert
near-infrared
laser
radiation
heat,
thereby
triggering
bacterial
death.
Moreover,
XKP
has
high
elasticity
tunable
water
content,
enabling
it
insulate
it,
providing
moist
environment
suitable
In-vivo
healing
results
clearly
demonstrate
that
can
significantly
accelerate
wounds
reducing
inflammatory
response
promoting
vascular
reconstruction.
summary,
strategy
provides
simple
practical
method
overcome
drawbacks
traditional
dressings,
further
options
when
choosing
materials
Chemistry of Materials,
Journal Year:
2022,
Volume and Issue:
34(6), P. 2655 - 2671
Published: March 10, 2022
The
development
of
multifunctional
injectable
adhesive
hydrogels
with
self-healing
capacity,
shape
adaptability,
on-demand
removability,
and
excellent
photothermal
antibacterial
activity
to
promote
bacteria-infected
wound
healing
is
highly
recommended
in
practical
applications.
In
this
work,
an
multiple-dynamic-bond
crosslinked
hydrogel
was
formed
by
a
network
dynamic
borate/didiol
interactions,
hydrogen
bonding,
Schiff
base
bond.
introduction
Mussel-inspired
catechol
groups
into
the
could
endow
tissues
properties,
adhere
well
skin
under
water
good
adaptability
bent
twisted
states.
mechanical
properties
improved
through
interactions
catechol-modified
crosslinking
at
low
cost
easy
preparation,
be
removed
without
second
damage
wound.
Moreover,
polydopamine
nanoparticles
(PDA
NPs)
were
introduced
reactions
between
quinone
group
on
PDA
NPs
primary
amine
glycol
chitosan
(GC),
resulting
efficient
uniformly
dispersed
hydrogel.
And
illustrated
cytocompatibility
hemocompatibility.
Finally,
they
injected
fully
fill
irregular
wounds
significantly
reducing
inflammatory
response,
accelerating
collagen
deposition,
promoting
blood
vessel
reconstruction.
Therefore,
demonstrated
their
superiority
serving
as
dressings
for
treating
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(22), P. 12371 - 12430
Published: Aug. 24, 2023
Nowadays,
the
increasing
emergence
of
antibiotic-resistant
pathogenic
microorganisms
requires
search
for
alternative
methods
that
do
not
cause
drug
resistance.
Phototherapy
strategies
(PTs)
based
on
photoresponsive
materials
have
become
a
new
trend
in
inactivation
due
to
their
spatiotemporal
controllability
and
negligible
side
effects.
Among
those
phototherapy
strategies,
photocatalytic
antimicrobial
therapy
(PCAT)
has
emerged
as
an
effective
promising
strategy
recent
years.
In
process
treatment,
are
excited
by
different
wavelengths
lights
produce
reactive
oxygen
species
(ROS)
or
other
toxic
killing
various
microbes,
such
bacteria,
viruses,
fungi,
parasites,
algae.
Therefore,
this
review
timely
summarizes
latest
progress
PCAT
field,
with
emphasis
development
antimicrobials
(PCAMs),
underlying
mechanisms,
design
multiple
practical
applications
local
infections
therapy,
personal
protective
equipment,
water
purification,
coatings,
wound
dressings,
food
safety,
antibacterial
textiles,
air
purification.
Meanwhile,
we
also
present
challenges
perspectives
widespread
implementation
therapeutics.
We
hope
result
review,
will
flourish
weapon
against
antibiotic
