Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives DOI Creative Commons
Min Chen,

Huanrong Lan,

Ketao Jin

et al.

Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1)

Published: June 8, 2023

The pharmacological approach to treating gastrointestinal diseases is suffering from various challenges. Among such diseases, ulcerative colitis manifests inflammation at the colon site specifically. Patients notably exhibit thin mucus layers that offer increased permeability for attacking pathogens. In majority of patients, conventional treatment options fail in controlling symptoms disease leading distressing effects on quality life. Such a scenario due failure therapies target loaded moiety into specific diseased sites colon. Targeted carriers are needed address this issue and enhance drug effects. Conventional nanocarriers mostly readily cleared have nonspecific targeting. To accumulate desired concentration therapeutic candidates inflamed area colon, smart nanomaterials with responsive nature been explored recently include pH responsive, reactive oxygen species (ROS), enzyme thermo - nanocarrier systems. formulation nanotechnology scaffolds has resulted selective release drugs, avoiding systemic absorption limiting undesired delivery targeting drugs healthy tissues. Recent advancements field systems fabrication multi-responsive i.e. dual derivitization biological tissues nanocarrier's interaction. addition, it also led efficient significant cellular uptake moieties. Herein, we highlighted latest status system, its applications on-demand colitis, prospects underpinned.

Language: Английский

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy DOI
Chen Zhang, Jiaxin Li, Meng Xiao

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 33(11), P. 4924 - 4929

Published: April 2, 2022

Language: Английский

Citations

118
Orally deliverable sequence-targeted astaxanthin nanoparticles for colitis alleviation DOI
Yannan Chen, Wentao Su, Shanshan Tie

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 293, P. 121976 - 121976

Published: Dec. 22, 2022

Language: Английский

Citations

86
Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease DOI
Yuji Pu, Fan Xi, Zhuangzhuang Zhang

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 354, P. 1 - 18

Published: Dec. 27, 2022

Language: Английский

Citations

78
Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity DOI
Azin Rashidy Ahmady, Atefeh Solouk, Saeed Saber‐Samandari

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 638, P. 616 - 628

Published: Jan. 31, 2023

Language: Английский

Citations

66
An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease DOI
Fan Xi, Zhuangzhuang Zhang, Wenxia Gao

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 229 - 244

Published: Dec. 19, 2023

Colonic epithelial damage and dysregulated immune response are crucial factors in the progression exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to inflamed intestinal mucosa has shown promise inducing maintaining colitis remission, while minimizing side effects. Inspired by excellent antioxidative anti-inflammatory efficacy naturally derived magnolol (Mag) gut homeostasis regulation microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag system for combinational therapy IBD. PSBA showed high butyrate content 22% effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH reduction-responsive release, ensuring efficient retention adhesion colon mice. PSBA@Mag not only normalized level reactive oxygen species effectors but also restored barrier function both ulcerative Crohn's mouse models. Importantly, promoted migration healing ability cells vitro vivo, sensitizing therapeutic animal Moreover, transcriptomics metabolism analyses revealed that mitigated inflammation suppressing production pro-inflammatory cytokines chemokines restoring lipid metabolism. Additionally, this nanomedicine modulated microbiota inhibiting pathogenic Proteus Escherichia-Shigella promoting proliferation beneficial probiotics, including Lachnoclostridium, Lachnospiraceae_NK4A136_group norank_f_Ruminococcaceae. Overall, our findings highlight potential butyrate-functionalized polymethacrylates versatile effective nanoplatforms repair combating IBD other gastrointestinal disorders.

Language: Английский

Citations

51
Emerging Fabrication Strategies of Hydrogels and Its Applications DOI Creative Commons
Fayaz Ali, Imran Khan, Jianmin Chen

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(4), P. 205 - 205

Published: March 24, 2022

Recently, hydrogels have been investigated for the controlled release of bioactive molecules, such as living cell encapsulation and matrices. Due to their remote controllability quick response, are widely used various applications, including drug delivery. The rate extent which drugs reach targets highly dependent on carriers in delivery systems; therefore demand biodegradable intelligent is progressively increasing. nature hydrogel has created much interest its use systems. first part this review focuses emerging fabrication strategies hydrogel, physical chemical cross-linking, well radiation cross-linking. second describes applications fields, In end, an overview application prepared from several natural polymers presented.

Language: Английский

Citations

64
Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis DOI Creative Commons
Chen Zhang, Xiao Wang, Meng Xiao

et al.

Materials & Design, Journal Year: 2022, Volume and Issue: 221, P. 110894 - 110894

Published: July 2, 2022

Although nano-systems can promote the cellular internalization, polymeric nanoparticles (NPs) are easily to be destroyed or eliminated in gastrointestinal tract, which leads premature drug release insufficient colonic accumulation. A novel oral nano-in-micro system for efficient delivery of curcumin (Cur) was developed this study, hyaluronic acid (HA)/zein complex NPs loading Cur were embedded alginate/chitosan hydrogel microparticles (Cur@NMPs) with electrospray technology. The Cur@NMPs showed uniform-sized sphere an average size 218.36 ± 10 μm, encapsulating Cur@HA/zein 148.64 3.21 nm. NMPs sustained drug-release profiles simulated gastric fluid, whereas it rapid fluid. Mediated by HA-CD44 receptor recognition, had increased uptake efficiency macrophages. Furthermore, significant colon-retention and bio-adhesiveness capacity colon tissues. As expected, administration significantly mitigated colitis symptoms DSS-induced UC mice inhibiting TLR4/NF-κB pathway. above results provide a useful strategy treatment retaining advantages nano- micro-scaled carriers.

Language: Английский

Citations

63
Application advance of electrosprayed micro/nanoparticles based on natural or synthetic polymers for drug delivery system DOI Creative Commons

Shiyi Zhao,

Chi Huang,

Yue Xuan

et al.

Materials & Design, Journal Year: 2022, Volume and Issue: 220, P. 110850 - 110850

Published: June 15, 2022

Micro/nanoparticles-based drug delivery system has emerged significantly and influenced the pharma industry up to considerable extent. At same time, development of production methods that are cost effective, scalable reproducible becomes crucial ensure clinical translation any development. The application electrospray (ES) technology in micro-nano not only above advantages, but also can quickly obtain uniform stable micro/nanoparticles as carriers through its own characteristics. Natural or synthetic polymers often used raw materials for these micro/nanoparticles. prepared by change solubility bioavailability drugs reduce toxicity caused mass accumulation after sudden release. And reaching target site, they're easy degrade will accumulate body. In this review, taken together, we briefly describe principle advantages ES, well common preparation method. types electrosprayed their systems different routes diseases were discussed. prospects made future field medicine.

Language: Английский

Citations

58
Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment DOI
Chi‐Pin James Wang, Min Ji Byun, Se−Na Kim

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 1 - 19

Published: Feb. 25, 2022

Language: Английский

Citations

54
Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair DOI Creative Commons

Fenting Lei,

Fancai Zeng, Xin Yu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 18, 2023

Due to oral nano-delivery systems for the treatment of inflammatory bowel disease (IBD) are often failed accumulated colonic site and could not achieve controlled drug release, it's urgent develop a microenvironment responsive delivery improve therapy efficacy. Inflammation at IBD is mainly mediated by macrophages, which key effector cells. Excessive inflammation leads oxidative stress intestinal mucosal damage. The use curcumin (CUR) emodin (EMO) together promising due their respective anti-inflammatory repair effects. In view pH gradient environment gastrointestinal tract, here we prepared pH-responsive sodium alginate (SA) hydrogel-coated nanoemulsions co-deliver CUR EMO (CUR/EMO NE@SA) release specifically target macrophages colon.In this study, CUR/EMO NE@SA was successfully developed, in NE loaded chitosan further crosslinked with alginate. had property colon. preparation significantly alleviate colon decreasing TNF-α IL-6 expression, increasing IL-10 scavenging reactive oxygen species ameliorating restoration tight junction protein expression. Furthermore, revealed molecular mechanism treatment, might synergic inhibition NF-κB pro-inflammatory microenvironment. Our study provides new strategy via synergically inhibiting inflammatory, repairing clearing ROS pH-sensitive hydrogel-encapsulated nanoemulsion system, be developed other chronic treatment.It's suggested that nanoemulsion-based codelivery combinatorial platform IBD.

Language: Английский

Citations

37