Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 33(11), P. 4924 - 4929

Published: April 2, 2022

Language: Английский

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Orally deliverable sequence-targeted astaxanthin nanoparticles for colitis alleviation

Biomaterials, Journal Year: 2022, Volume and Issue: 293, P. 121976 - 121976

Published: Dec. 22, 2022

Language: Английский

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Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 354, P. 1 - 18

Published: Dec. 27, 2022

Language: Английский

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Capsaicin-loaded alginate nanoparticles embedded polycaprolactone-chitosan nanofibers as a controlled drug delivery nanoplatform for anticancer activity

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 638, P. 616 - 628

Published: Jan. 31, 2023

Language: Английский

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An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 229 - 244

Published: Dec. 19, 2023

Colonic epithelial damage and dysregulated immune response are crucial factors in the progression exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to inflamed intestinal mucosa has shown promise inducing maintaining colitis remission, while minimizing side effects. Inspired by excellent antioxidative anti-inflammatory efficacy naturally derived magnolol (Mag) gut homeostasis regulation microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag system for combinational therapy IBD. PSBA showed high butyrate content 22% effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH reduction-responsive release, ensuring efficient retention adhesion colon mice. PSBA@Mag not only normalized level reactive oxygen species effectors but also restored barrier function both ulcerative Crohn's mouse models. Importantly, promoted migration healing ability cells vitro vivo, sensitizing therapeutic animal Moreover, transcriptomics metabolism analyses revealed that mitigated inflammation suppressing production pro-inflammatory cytokines chemokines restoring lipid metabolism. Additionally, this nanomedicine modulated microbiota inhibiting pathogenic Proteus Escherichia-Shigella promoting proliferation beneficial probiotics, including Lachnoclostridium, Lachnospiraceae_NK4A136_group norank_f_Ruminococcaceae. Overall, our findings highlight potential butyrate-functionalized polymethacrylates versatile effective nanoplatforms repair combating IBD other gastrointestinal disorders.

Language: Английский

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Colon‐Targeted Ginseng Polysaccharides‐Based Microspheres for Improving Ulcerative Colitis via Anti‐Inflammation and Gut Microbiota Modulation

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Natural plant‐derived polysaccharides exhibit substantial potential for treating ulcerative colitis (UC) owing to their anti‐inflammatory and antioxidant properties favorable safety profiles. However, practical application faces several challenges, including structural instability in gastric acid, imprecise targeting of inflamed regions, limited intestinal retention times. To address these limitations, pH‐responsive, colon‐targeting microspheres (pWGPAC MSs) are developed delivering phosphorylated wild ginseng (pWGP) alleviate UC. These pWGPAC MSs fabricated by incorporating pWGP into calcium‐crosslinked alginate with subsequent chitosan surface modification enhance mucosal adhesion. demonstrated exceptional stability under acidic conditions while enabling targeted release the colon. In a mouse model UC, effectively mitigated injury, attenuated inflammation, restored barrier function. Further mechanistic investigations revealed that modulated TLR4/MYD88 signaling pathway promoted M2 macrophage polarization. Integrated microbiome metabolome analyses regulated gut microbiota composition decreased pro‐inflammatory metabolite levels. addition, promising Collectively, findings establish as therapeutic strategy treatment UC provide solid foundation future clinical applications.

Language: Английский

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Emerging Fabrication Strategies of Hydrogels and Its Applications

Gels, Journal Year: 2022, Volume and Issue: 8(4), P. 205 - 205

Published: March 24, 2022

Recently, hydrogels have been investigated for the controlled release of bioactive molecules, such as living cell encapsulation and matrices. Due to their remote controllability quick response, are widely used various applications, including drug delivery. The rate extent which drugs reach targets highly dependent on carriers in delivery systems; therefore demand biodegradable intelligent is progressively increasing. nature hydrogel has created much interest its use systems. first part this review focuses emerging fabrication strategies hydrogel, physical chemical cross-linking, well radiation cross-linking. second describes applications fields, In end, an overview application prepared from several natural polymers presented.

Language: Английский

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Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis

Materials & Design, Journal Year: 2022, Volume and Issue: 221, P. 110894 - 110894

Published: July 2, 2022

Although nano-systems can promote the cellular internalization, polymeric nanoparticles (NPs) are easily to be destroyed or eliminated in gastrointestinal tract, which leads premature drug release insufficient colonic accumulation. A novel oral nano-in-micro system for efficient delivery of curcumin (Cur) was developed this study, hyaluronic acid (HA)/zein complex NPs loading Cur were embedded alginate/chitosan hydrogel microparticles (Cur@NMPs) with electrospray technology. The Cur@NMPs showed uniform-sized sphere an average size 218.36 ± 10 μm, encapsulating Cur@HA/zein 148.64 3.21 nm. NMPs sustained drug-release profiles simulated gastric fluid, whereas it rapid fluid. Mediated by HA-CD44 receptor recognition, had increased uptake efficiency macrophages. Furthermore, significant colon-retention and bio-adhesiveness capacity colon tissues. As expected, administration significantly mitigated colitis symptoms DSS-induced UC mice inhibiting TLR4/NF-κB pathway. above results provide a useful strategy treatment retaining advantages nano- micro-scaled carriers.

Language: Английский

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Application advance of electrosprayed micro/nanoparticles based on natural or synthetic polymers for drug delivery system

Materials & Design, Journal Year: 2022, Volume and Issue: 220, P. 110850 - 110850

Published: June 15, 2022

Micro/nanoparticles-based drug delivery system has emerged significantly and influenced the pharma industry up to considerable extent. At same time, development of production methods that are cost effective, scalable reproducible becomes crucial ensure clinical translation any development. The application electrospray (ES) technology in micro-nano not only above advantages, but also can quickly obtain uniform stable micro/nanoparticles as carriers through its own characteristics. Natural or synthetic polymers often used raw materials for these micro/nanoparticles. prepared by change solubility bioavailability drugs reduce toxicity caused mass accumulation after sudden release. And reaching target site, they're easy degrade will accumulate body. In this review, taken together, we briefly describe principle advantages ES, well common preparation method. types electrosprayed their systems different routes diseases were discussed. prospects made future field medicine.

Language: Английский

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Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 1 - 19

Published: Feb. 25, 2022

Language: Английский

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