Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 165 - 165
Published: Feb. 26, 2025
Hypericum
perforatum
L.
(H.P.)
is
a
species
with
well-documented
history
of
use
in
wound
healing
practices
across
the
globe.
The
objective
this
study
was
twofold:
firstly,
to
evaluate
vivo
efficacy
liposomal
situ
gel
formulations
healing,
both
clinically
and
histopathologically,
secondly,
determine
physicochemical
characterization
formulations.
vitro
studies
will
be
assessed
terms
particle
size,
zeta
potential,
release
kinetics,
rheological
behaviors,
antioxidant
antimicrobial
properties.
evaluated
clinical
animal
experiments
pathology
studies.
in-situ
hydrogel
were
prepared
using
physical
cross-linking
method
Poloxamer
188,
407,
Ultrez
21,
30.
liposome
phospholipid
90H
lipoid
S100
thin
film
solvent
evaporation
method.
activity
samples
through
employing
DPPH
activity,
ABTS+
test,
FRAP
test.
determination
MIC
MBC
values
96-well
plate
In
vivo,
36
male
New
Zealand
rabbits
aged
32–36
weeks
utilized,
six
each
group.
groups
composed
distinct
groups,
including
conventional
HHPM,
three
different
commercial
preparations,
control
group
(n
=
6).
HHPM-LG8
formulation
developed
found
applicable
all
its
new
demonstrated
notable
result
that
supported
by
itself.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 31, 2025
Nanotechnology
has
witnessed
remarkable
advancements
in
recent
years,
capturing
considerable
attention
diverse
biomedical
applications.
Using
the
green
precipitation
method,
this
study
aims
to
synthesize
and
characterize
chitosan/polyvinyl
alcohol-copper
oxide
nanocomposites
(CS/PVA/CuONCs)
using
Anacardium
occidentale
plant
fruit
extract.
The
CS/PVA/CuONCs
were
further
evaluated
antioxidant,
antibacterial
biological
activities.
In
our
results,
UV-Vis
spectrum
analysis
of
revealed
a
peak
at
430
nm.
FTIR
analyses
confirmed
presence
different
functional
groups,
while
XRD
crystalline
structure
synthesized
nanocomposites.
FESEM-EDAX
demonstrated
that
exhibited
spherical
rod-like
shape,
with
an
average
particle
size
48.6
96.2
Notably,
higher
antioxidant
activity,
as
evidenced
by
their
ABTS
activity
(83.79
±
1.57%)
SOD
(86.17
1.28%).
assays,
inhibition
Escherichia
coli
20.52
0.85
mm
Bacillus
subtilis
19.64
0.87
mm,
displaying
zone
inhibition.
excellent
anti-inflammatory
potency
against
COX-1
(67.10
0.58%)
COX-2
(76.39
0.65%).
antidiabetic
assay
α-amylase
(80.25
1.29%)
α-glucosidase
(84.74
1.42%)
Anti-cholinergic
AChE
was
65.35
0.98%
BuChE
82.46
1.15%
are
observed.
shown
have
strong
cytotoxicity
MCF-7
cell
lines.
It
also
had
highest
viability
inhibition,
13.66
0.58%.
hemolysis
found
be
5.38
0.34%.
Overall,
possess
remarkably
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Abstract
Bacterial
infections
are
a
significant
obstacle
to
the
healing
of
acute
and
chronic
wounds,
such
as
diabetic
ulcers
burn
injuries.
Traditional
antibiotics
primary
treatment
for
bacterial
infections,
but
they
present
issues
antibiotic
resistance,
limited
efficacy,
potential
side
effects.
This
challenge
leads
exploration
nanozymes
alternative
therapeutic
agents.
Nanozymes
nanomaterials
with
enzyme‐like
activities.
Owing
their
low
production
costs,
high
stability,
scalability,
multifunctionality,
have
emerged
prominent
focus
in
antimicrobial
research.
Among
various
types
nanozymes,
metal‐based
offer
several
benefits,
including
broad‐spectrum
activity
robust
catalytic
properties.
Specifically,
copper‐based
(CuNZs)
shown
considerable
promoting
wound
healing.
They
exhibit
strong
effects,
reduce
inflammation,
enhance
tissue
regeneration,
making
them
highly
advantageous
use
care.
review
describes
dual
functions
CuNZs
combating
infection
facilitating
repair.
Recent
advancements
design
synthesis
CuNZs,
evaluating
promotion,
biosafety
both
vitro
vivo
on
basis
core
components,
critically
important.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: Sept. 8, 2022
The
rapid
development
of
tissue
engineering
makes
it
an
effective
strategy
for
repairing
cartilage
defects.
significant
advantages
injectable
hydrogels
injury
include
the
properties
natural
extracellular
matrix
(ECM),
good
biocompatibility,
and
strong
plasticity
to
adapt
irregular
defect
surfaces.
These
inherent
make
a
promising
tool
engineering.
This
paper
reviews
research
progress
on
advanced
hydrogels.
cross-linking
method
structure
are
thoroughly
discussed.
Furthermore,
polymers,
cells,
stimulators
commonly
used
in
preparation
reviewed.
Finally,
we
summarize
latest
repair
future
challenges
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(3), P. 934 - 950
Published: Feb. 15, 2023
With
over
2
million
cancer
cases
and
600,000
cancer-associated
deaths
predicted
in
the
U.S.
for
2022,
this
life-debilitating
disease
continuously
impacts
lives
of
people
across
nation
every
day.
Therapeutic
treatment
options
have
historically
involved
chemotherapies
to
eradicate
tumors
with
cytotoxic
mechanisms
which
can
negatively
affect
efficacy
versus
toxicity
ratio
treatment.
a
need
more
directed
therapeutically
active
options,
targeted
small-molecule
inhibitors
immunotherapies
since
emerged
mitigate
treatment-associated
toxicities.
However,
aggressive
employ
wide
range
defense
evade
monotherapy
altogether,
resulting
recurrence
resistant
tumors.
Therefore,
many
clinical
routines
included
combination
therapy
anticancer
agents
are
combined
provide
synergistic
attack
on
Even
approach,
maximizing
is
contingent
upon
dose
drug
that
reaches
site
tumor,
so
often
administered
at
tumor
via
localized
delivery
platforms.
Commonly
used
platforms
include
polymeric
wafers,
nanofibrous
scaffolds,
hydrogels
where
combinations
be
loaded
delivered
synchronously.
Attaining
activity
from
these
systems
dependent
proper
material
selection
fabrication
methods.
Herein,
we
describe
important
considerations
enhancing
through
biodegradable,
systems.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 18, 2024
Aims:
Breast
cancer
is
the
most
common
malignancy
among
women
in
both
high-
and
low-resource
settings.
Conventional
breast
therapies
were
inefficient
had
low
patient
compliance.
Stimuli-responsive
hydrogels
possessing
similar
physicochemical
features
as
soft
tissue
facilitate
diagnostic
therapeutic
approaches
for
subtypes.
Scope:
Polysaccharides
polypeptides
are
major
natural
polymers
with
unique
biocompatibility,
biodegradability,
feasible
modification
utilized
frequently
hydrogel
fabrication.
Alternating
polymer-based
properties
response
to
external
stimuli
such
pH,
temperature,
light,
ultrasonic,
enzyme,
glucose,
magnetic,
redox,
electric
have
provided
great
potential
evolution
of
novel
drug
delivery
systems
(DDSs)
various
advanced
technologies
medical
applications.
triggered
by
specific
features,
promote
target
techniques,
modify
release
agents
at
localized
sites.
This
narrative
review
presented
innovation
preparing
characterizing
stimuli-responsive
applications
area.
Conclusion:
display
bioinspiration
products
DDSs
subtypes,
protect
shape
tissue,
provide
modified
release,
enhance
efficacy,
minimize
chemotherapy
agents’
side
effects.
The
benefits
smart
make
them
an
exciting
area
practice
diagnosis
treatment.
