Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123693 - 123693

Published: Feb. 17, 2023

Language: Английский

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Alginate: Microbial production, functionalization, and biomedical applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 125048 - 125048

Published: May 25, 2023

Language: Английский

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From Nature‐Sourced Polysaccharide Particles to Advanced Functional Materials

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 23, 2024

Polysaccharides constitute over 90% of the carbohydrate mass in nature, which makes them a promising feedstock for manufacturing sustainable materials. Polysaccharide particles (PSPs) are used as effective scavengers, carriers chemical and biological cargos, building blocks fabrication macroscopic The biocompatibility degradability PSPs advantageous their uses biomaterials with more environmental friendliness. This review highlights progresses PSP applications advanced functional materials, by describing extraction, preparation, surface functionalization variety groups, polymers, nanoparticles, biologically active species. also outlines PSP-derived well soft robotics, sensing, scavenging, water harvesting, drug delivery, bioengineering. paper is concluded an outlook providing perspectives development

Language: Английский

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Recent advances of electrospray technique for multiparticulate preparation: Drug delivery applications

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 325, P. 103098 - 103098

Published: Feb. 4, 2024

Language: Английский

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Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Polymers, Journal Year: 2022, Volume and Issue: 14(19), P. 4189 - 4189

Published: Oct. 6, 2022

Polysaccharides constitute one of the most important families biopolymers. Natural polysaccharide-based drug delivery systems are constant interest to scientific community due their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents provide controlled release in targeted sites. The application natural polysaccharides as is also intensively developed by Polish scientists. present review focuses on case studies from last few years authored or co-authored research centers Poland. A particular emphasis was placed diversity formulations terms substance carried, route, composition material, its preparation method.

Language: Английский

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pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(45), P. 50692 - 50709

Published: Nov. 3, 2022

Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH severely limited by its low water solubility, bioavailability, poor colonic targeting. Although some nanoparticles have been developed oral delivery RH, most them mainly highlighted only one effect drug strategies but above activities. Therefore, polysaccharide-based nanodelivery system, comprising chitosan (CS) fucoidan (FU), with pH/reactive oxygen species (ROS) sensitivity mucosal adhesion, was first used load as comprehensive UC. Briefly, RH-F/C-NPs were prepared using polyelectrolyte self-assembly method; average size 233.1 ± 5.7 nm, encapsulation rate 93.67 1.60%. And it could maintain gastric stability release in colon designed pH/ROS contributed structures. Cellular uptake experiments showed that both NCM 460 cells RAW 264.7 had good RH-F/C-NPs. Importantly, effects vivo experiments, results which significantly reduce DSS-induced inflammation inhibiting TLR4/NF-κB-mediated anti-inflammatory pathway, Nrf2/HO-1-mediated antioxidant In addition, pharmacokinetic studies shown F/C-NPs increase plasma concentration accumulation extent. short, this study develop nanosystem dual "one stone four birds" therapeutic on

Language: Английский

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A novel hyaluronic acid-based dissolving microneedle patch loaded with ginsenoside Rg3 liposome for effectively alleviate psoriasis

Materials & Design, Journal Year: 2022, Volume and Issue: 224, P. 111363 - 111363

Published: Nov. 10, 2022

Psoriasis is a chronic scaly skin disease, which associated with abnormal immune system function, inflammatory cell infiltration. The disadvantages of traditional treatment psoriasis are poor efficacy, recurrence the condition, long time, and systemic side effects due to lack an appropriate drug delivery system. A liposome-in-Microneedles (MNs) based transdermal had been developed provide efficient site-specific delivery, stable release enhanced permeability. Firstly, liposomes were loaded Ginsenoside Rg3 (a small molecular compound anti-inflammatory regulation functions), then Rg3-liposomes (Rg3-Lipo) successfully into MNs. Rg3-Liposome-MNs (Rg3-MNs) mechanical property 0.59 N/needle, could easily penetrate epidermis Rg3-lipo regulate response. efficacy Rg3-MNs was evaluated by IMQ-induced psoriasis-like dermatitis in mice. significantly (p < 0.01) decreased epidermal thickness, dermal papillary edema, possible mechanism markedly reduce levels IL-17, IL-23, TNF-α. In addition, we found that might improve inhibiting activation STAT3/p-STAT3 signaling pathway. brief, this study provides ideal immunoregulatory treat psoriasis.

Language: Английский

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Antifungal electrospinning nanofiber film incorporated with Zanthoxylum bungeanum essential oil for strawberry and sweet cherry preservation

LWT, Journal Year: 2022, Volume and Issue: 169, P. 113992 - 113992

Published: Sept. 19, 2022

Given that the high incidences of fruit mildew especially for strawberry and cherry during storage, green, edible, antifungal package materials was greatly required to improve shelf-life. Herein, an active film encapsulating Zanthoxylum bungeanum essential oil (ZBEO, 10%) into polyvinyl alcohol/β-Cyclodextrin (PVA/β-CD, 6:1) nanofibers fabricated via electrospinning technology, based on specific process optimization. ZBEO/Film composing (∼185 nm average diameter) exhibited adequate mechanical properties, in which tensile strength (TS), Young's modulus (YM), elongation at break (EAB) were 10.69 ± 1.97 MPa, 58.27 5.58%, 268.64 64.28 respectively, higher water vapor permeability (34.9464 g mm/kPa∙m2∙d), high-water contact angle value 104.7°. The significant activities ZBEO/Films against Penicillium, Aspergillus flavus or Botrytis cinerea have been presented by vitro. Finally, after spreading ZBEO/Films, both strawberries cherries could keep fresh 10 days compared severe other counterparts. Most importantly, these fruits treated with had highest sensory scores. All finding suggested developed nanofiber would be a promising packaging material anti-fungal fresh-keeping advantages.

Language: Английский

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Advances in chitosan-based hydrogels for pharmaceutical and biomedical applications: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127278 - 127278

Published: Oct. 6, 2023

Language: Английский

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