The History of Electrospinning: Past, Present, and Future Developments

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 8(11)

Published: May 5, 2023

Abstract Electrospinning has rapidly progressed over the past few decades as an easy and versatile way to fabricate fibers with diameters ranging from micrometers tens of nanometers that present unique intricate morphologies. This led conception new technologies diverse methods exploit basic electrohydrodynamic phenomena electrospinning process, which in turn invention novel apparatuses have reshaped field. Research on revamping conventional principally focused achieving three key objectives: upscaling process while retaining consistent morphological traits, developing 3D nanofibrous macrostructures, formulating fiber configurations. review introduces extensive group techniques presents a comperative study based apparatus type output. Then, each process's advantages limitations are critically assessed identify bona fide practicability relevance technological breakthrough. Finally, outlook future developments advanced is outlined, emphasis upscaling, translational research, sustainable manufacturing prospective solutions current shortcomings.

Language: Английский

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Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(6), P. 1375 - 1413

Published: Sept. 16, 2022

Abstract Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. We first introduce the construction of fiber scaffolds their various structures, as well commonly used types drugs. Then, we discuss some representative controlling by fibers, with specific emphasis on design endogenous external stimuli-responsive systems. Afterwards, summarize recent progress engineering, including soft engineering (such skin, nerve, cardiac repair) hard bone, cartilage, musculoskeletal systems), Furthermore, provide future development directions challenges facing use fibers controlled delivery, aiming insights perspectives smart platforms improve clinical therapeutic effects in Graphical abstract

Language: Английский

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Recent Progress in Electrospun Polyacrylonitrile Nanofiber-Based Wound Dressing

Polymers, Journal Year: 2022, Volume and Issue: 14(16), P. 3266 - 3266

Published: Aug. 11, 2022

Bleeding control plays a very important role in worldwide healthcare, which also promotes research and development of wound dressings. The healing process involves four stages hemostasis, inflammation, proliferation remodeling, is complex process, dressings play huge it. Electrospinning technology simple to operate. Electrospun nanofibers have high specific surface area, porosity, oxygen permeability, excellent mechanical properties, show great utilization value the manufacture As one most popular reactive functional synthetic polymers, polyacrylonitrile (PAN) frequently explored create for wide variety applications. In recent years, researchers invested application PAN Research on spun reviewed, future directions prospects electrospun are proposed.

Language: Английский

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Multi-material electrospinning: from methods to biomedical applications

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100710 - 100710

Published: June 25, 2023

Electrospinning as a versatile, simple, and cost-effective method to engineer variety of micro or nanofibrous materials, has contributed significant developments in the biomedical field. However, traditional electrospinning single material only can produce homogeneous fibrous assemblies with limited functional properties, which oftentimes fails meet ever-increasing requirements applications. Thus, multi-material referring engineering two more kinds been recently developed enable fabrication diversified complex structures advanced performance for greatly promoting development. This review firstly gives an overview modalities, highlight on their features accessibility constructing different structures. A perspective how opens up new opportunities specific applications, i.e., tissue drug delivery, is also offered.

Language: Английский

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Luminescent MOF-Based Nanofibers with Visual Monitoring and Antibacterial Properties for Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(7), P. 9110 - 9119

Published: Feb. 8, 2023

Diabetic wound healing remains as a serious challenge for medical circles that required continuous monitoring and effective management. Herein, the glucose oxidase/carbon dots@copper-metal–organic framework-based nanofibers (GOx/CDs@MOF NFs) were proposed multifunctional dressing, aiming to visually monitor pH inhibit bacterial infection. In diabetic microenvironment, GOx/CDs@MOF NFs could convert endogenous into hydroxyl radial (•OH) through cascade catalytic reaction. vivo vitro experimental results confirmed efficiently kill bacteria promote healing. Additionally, CDs fluorescent indicator endowed with sensitive reversible sensing behavior pH, these visual images also be captured by smartphones transformed RGB color mode (red, green, blue) values, allowing onsite evaluation of status. This dressing provides smart solution management takes an immeasurable step toward development next generation digitally visualized dressings.

Language: Английский

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Tannic acid-functionalized 3D porous nanofiber sponge for antibiotic-free wound healing with enhanced hemostasis, antibacterial, and antioxidant properties

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 13, 2023

Developing an antibiotic-free wound dressing with effective hemostasis and antibacterial antioxidant capacity is highly desirable. In this work, a three-dimensional (3D) chitosan/polyvinyl alcohol-tannic acid porous nanofiber sponge (3D-TA) was prepared via electrospinning. Compared two-dimensional (2D) fiber membrane, the unique fluffy 3D-TA had high porosity, water absorption retention ability, hemostatic capacity. Furthermore, 3D functionalized by tannic (TA) endow without loading antibiotics. addition, composite sponges have shown biocompatibility against L929 cells. The in vivo experiment shows enable to accelerate healing. This newly hold great potential as dressings for future clinical application.

Language: Английский

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Anti‐Dehydration and Rapid Trigger‐Detachable Multifunctional Hydrogels Promote Scarless Therapeutics of Deep Burn

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(17)

Published: Feb. 1, 2023

Abstract There are issues and challenges in treating deep burns because of the long recovery time, frequent dressing changes, wound infection, easy to form scar that influence aesthetics. Besides, some specific tissues not suitable for large coverage (e.g., face, perineum). Therefore, an ideal burn should have good adhesion properties fit effectively, painless quick replacement, resistant accelerate healing, reduce scarring facilitate monitoring diagnosis. Herein, anti‐dehydration rapid‐trigger multifunctional hydrogel is prepared by interface reaction. The Pacrylamide‐Formylboronicacid‐Tannic acid (PAFT) hydrogels a simple method on elastomeric membrane, which obtained using tannic as dynamic cross‐linking agent with 3‐formylboronic acrylamideunder UV light. exhibits strong interfacial (892 J m −2 ± 65 ), rapidly (2 min) decreases (to 180 20 ) when presence glucose solution. has excellent moisturizing properties, also superior antibacterial hemostasis, biocompatibility. This transparent allowing effective observation transformation therapeutics. Moreover, PAFT accelerates healing reduces scars.

Language: Английский

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Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

RSC Advances, Journal Year: 2024, Volume and Issue: 14(5), P. 3359 - 3378

Published: Jan. 1, 2024

Electrostatic spinning as a technique for producing nanoscale fibers has recently attracted increasing attention due to its simplicity, versatility, and loadability.

Language: Английский

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Multifunctional dressings for wound exudate management

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 146, P. 101328 - 101328

Published: June 14, 2024

Language: Английский

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Extracellular Matrix‐Bioinspired Anisotropic Topographical Cues of Electrospun Nanofibers: A Strategy of Wound Healing through Macrophage Polarization

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 31, 2024

Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.

Language: Английский

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