Materials & Design,
Journal Year:
2024,
Volume and Issue:
241, P. 112967 - 112967
Published: April 29, 2024
Hemostatic
materials
that
allow
fast
and
convenient
hemostasis
are
urgently
needed.
However,
obtaining
an
ideal
hemostatic
agent
exhibits
biocompatibility,
biodegradability,
efficacy
remains
challenging.
Recent
studies
demonstrate
morphological
characteristics
of
impact
their
efficacy.
This
study
reports
on
the
importance
modification
traditional
Chinese
medicine
plant
polysaccharides.
The
properties
Three-leaf
Qing
polysaccharides,
optimized
in
particle
(SYQ-P)
sponge
(SYQ-S)
forms,
were
investigated
vitro
vivo.
SYQ-S
SYQ-P
exhibit
excellent
biodegradability
thereby
improving
fibroblast
cell
proliferation.
mechanism
involves
stable
blood
clot
formation
through
intrinsic
coagulation
pathways.
In
a
lethal
mouse
liver
defect
bleeding
model,
loss
clotting
time
lower
with
polysaccharides
use
than
commercial
drugs.
demonstrates
instant
water-triggered
expansion
high
absorption
capacity,
while
sponge-like
effectively
improve
component
concentrations.
With
efficient
dramatically
accelerated
wound
healing
full-thickness
skin
model
Thus,
promotes
granulation
tissue,
collagen
deposition,
angiogenesis,
which
ultimately
accelerates
healing.
Our
work
highlights
design
natural
presents
promising
for
widespread
clinical
application.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 27, 2024
Abstract
The
development
of
innovative
wound
dressing
materials
is
crucial
for
effective
care.
It’s
an
active
area
research
driven
by
a
better
understanding
chronic
pathogenesis.
Addressing
care
properly
clinical
challenge,
but
there
growing
demand
advancements
in
this
field.
synergy
medicinal
plants
and
nanotechnology
offers
promising
approach
to
expedite
the
healing
process
both
acute
wounds
facilitating
appropriate
progression
through
various
phases.
Metal
nanoparticles
play
increasingly
pivotal
role
promoting
efficient
preventing
secondary
bacterial
infections.
Their
small
size
high
surface
facilitate
enhanced
biological
interaction
penetration
at
site.
Specifically
designed
topical
drug
delivery,
these
enable
sustained
release
therapeutic
molecules,
such
as
growth
factors
antibiotics.
This
targeted
ensures
optimal
cell-to-cell
interactions,
proliferation,
vascularization,
fostering
controlled
healing.
Nanoscale
scaffolds
have
significant
attention
due
their
attractive
properties,
including
delivery
capacity,
porosity
area.
They
mimic
Extracellular
matrix
(ECM)
hence
biocompatible.
In
response
alarming
rise
antibiotic-resistant,
biohybrid
nanofibrous
dressings
are
gradually
replacing
conventional
antibiotic
systems.
emerging
class
comprises
biopolymeric
nanofibers
with
inherent
antibacterial
nature-derived
compounds,
biofunctional
agents.
Nanotechnology,
diminutive
nanomaterials,
nanoscaffolds,
nanofibers,
biomaterials
harnessed
aimed
review
article
discusses
effects
loaded
on
healing,
(in
vivo
vitro)
mechanical
outcomes.
Graphical
Materials,
Journal Year:
2023,
Volume and Issue:
16(17), P. 6021 - 6021
Published: Sept. 1, 2023
Electrospun
nanofiber
membranes
(NFMs)
have
high
porosity
and
a
large
specific
surface
area,
which
provide
suitable
environment
for
the
complex
dynamic
wound
healing
process
number
of
sites
carrying
factors.
Further,
design
structure
can
imitate
human
dermis,
similar
to
natural
extracellular
matrix,
better
promotes
hemostasis,
anti-inflammatory
wounds.
Therefore,
it
has
been
widely
studied
in
field
dressing.
This
review
article
overviews
development
electrospinning
technology
application
electrospun
nanofibers
dressings.
It
begins
with
an
introduction
history,
working
principles,
transformation
electrospinning,
focus
on
selection
materials,
incorporation
functional
therapeutic
factors,
structural
membranes.
Moreover,
wide
NFMs
containing
factors
is
classified
based
their
special
functions,
such
as
antibacterial
cell
proliferation
promotion.
also
highlights
dressing,
including
porous
structures,
bead
core-shell
ordered
multilayer
membrane
structures.
Finally,
advantages
limitations
are
discussed,
challenges
faced
dressings
analyzed
promote
further
research
this
field.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2526 - 2526
Published: Sept. 5, 2024
Skin,
the
largest
organ
of
human
body,
accounts
for
protecting
against
external
injuries
and
pathogens.
Despite
possessing
inherent
self-regeneration
capabilities,
repair
skin
lesions
is
a
complex
time-consuming
process
yet
vital
to
preserving
its
critical
physiological
functions.
The
dominant
treatment
involves
application
dressing
protect
wound,
mitigate
risk
infection,
decrease
likelihood
secondary
injuries.
Pursuing
solutions
accelerating
wound
healing
has
resulted
in
groundbreaking
advancements
materials
science,
from
hydrogels
hydrocolloids
foams
micro-/nanofibers.
Noting
convenience
flexibility
design,
nanofibers
merit
high
surface-area-to-volume
ratio,
controlled
release
therapeutics,
mimicking
extracellular
matrix,
excellent
mechanical
properties.
Core-shell
bring
even
further
prospects
realm
dressings
upon
separate
compartments
with
independent
functionality,
adapted
profiles
bioactive
agents,
better
moisture
management.
In
this
review,
we
highlight
core-shell
applications
featuring
survey
on
common
synthesis
methods.
Our
discussion
embodies
process,
optimal
characteristics,
current
organic
inorganic
material
repertoire
multifunctional
nanofibers,
techniques
fabricate
proper
coaxial
structures.
We
also
provide
an
overview
antibacterial
nanomaterials
emphasis
their
crystalline
structures,
properties,
conclude
outlook
potential
offered
by
toward
more
advanced
design
effective
healing.
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(10), P. 1226 - 1226
Published: Sept. 30, 2024
Non-invasive
medical
nanofiber
technology,
characterized
by
its
high
specific
surface
area,
biocompatibility,
and
porosity,
holds
significant
potential
in
various
domains,
including
tissue
repair
biosensing.
It
is
increasingly
becoming
central
to
healthcare
offering
safer
more
efficient
treatment
options
for
contemporary
medicine.
Numerous
studies
have
explored
non-invasive
nanofibers
recent
years,
yet
a
comprehensive
overview
of
the
field
remains
lacking.
In
this
paper,
we
provide
summary
applications
electrospun
fields,
considering
multiple
aspects
perspectives.
Initially,
introduce
electrospinning
nanofibers.
Subsequently,
detail
their
health,
health
monitoring,
personal
protection,
thermal
regulation,
wound
care,
highlighting
critical
role
improving
human
health.
Lastly,
paper
discusses
current
challenges
associated
with
offers
insights
into
future
development
trajectories.
