Emergent Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Language: Английский
Deleted Journal, Journal Year: 2024, Volume and Issue: 3(1), P. 200113 - 200113
Published: Jan. 18, 2024
In recent years, there has been significant growth in the demand from both domestic and international markets for ceramic 3D printing technology. This surge interest led to rapid advancements research application. Ceramic applied successfully diverse fields, including healthcare, cultural creativity, architectural decoration. Its appeal lies eliminating need molds during manufacturing, resulting cost-effectiveness, high production efficiency, unparalleled freedom structural design. Compared traditional molding processes, various industries have widely embraced advantages of printing. The current focus researchers strategic emerging such as aerospace, electronic communication. Researchers conduct multifaceted on technology these areas are eager invest industrial development. article overviews latest application progress fields above. addition, it analyzes challenges technical bottlenecks faced by different domains. Moreover, this study explores opportunities demands further development materials development, equipment field expansion. By examining aspects, sheds light immense potential that holds future innovation.
Language: Английский
Citations
31
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 7, 2024
The treatment of critical-size bone defects with irregular shapes remains a major challenge in the field orthopedics. Bone implants adaptability to complex morphological defects, bone-adhesive properties, and potent osteogenic capacity are necessary. Here, shape-adaptive, highly bone-adhesive, ultrasound-powered injectable nanocomposite hydrogel is developed via dynamic covalent crosslinking amine-modified piezoelectric nanoparticles biopolymer networks for electrically accelerated healing. Depending on inorganic-organic interaction between amino-modified bio-adhesive network, adhesive strength prepared exhibited an approximately 3-fold increase. In response ultrasound radiation, could generate controllable electrical output (-41.16 61.82 mV) enhance effect vitro vivo significantly. Rat calvarial defect repair validates addition, bioinformatics analysis reveals that ultrasound-responsive enhanced differentiation mesenchymal stem cells by increasing calcium ion influx up-regulating PI3K/AKT MEK/ERK signaling pathways. Overall, present work novel wireless broadens therapeutic horizons defects.
Language: Английский
Citations
25
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 19, 2024
There has been increasing attention to produce porous scaffolds that mimic human bone properties for enhancement of tissue ingrowth, regeneration, and integration. Additive manufacturing (AM) technologies, i.e., three dimensional (3D) printing, have played a substantial role in engineering clinical applications owing their high level design fabrication flexibility. To this end, review article attempts provide detailed overview on the main considerations such as permeability, adhesion, vascularisation, interfacial features interplay affect regeneration osseointegration. Physiology was initially explained followed by analysing impacts porosity, pore size, permeability surface chemistry defects. Importantly, major 3D printing methods employed substitutes were also discussed. Advancements MA technologies allowed production with complex geometries polymers, composites metals well-tailored architectural, mechanical, mass transport features. In way, particular devoted reviewing printed triply periodic minimal (TPMS) hierarchical structure bones. overall, enlighten pathway patient-specific 3D-printed substitutions osseointegration capacity repairing large
Language: Английский
Citations
23
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 31, 2024
Abstract The osteoimmune microenvironment induced by implants plays a significant role in bone regeneration. It is essential to efficiently and timely switch the macrophage phenotype from M1 M2 for optimal healing. This study examined impact of calcium phosphate (CaP) coating on physiochemical properties highly ordered polycaprolactone (PCL) scaffolds fabricated using melt electrowritten (MEW). Additionally, it investigated influence these polarization their immunomodulation osteogenesis. results revealed that CaP coated PCL scaffold exhibited rougher surface topography higher hydrophilicity comparison without coating. Besides, morphology release Ca 2+ were crucial regulating transition macrophages phenotypes. They might activate PI3K/AKT cAMP-PKA pathways, respectively, facilitate polarization. In addition, could not only enhance osteogenic differentiation marrow-derived mesenchymal stem cells (BMSCs) vitro but also promote regeneration vivo. Taken together, can be employed control phenotypic switching macrophages, thereby creating beneficial immunomodulatory promotes Graphical abstract
Language: Английский
Citations
20
Small, Journal Year: 2024, Volume and Issue: 20(23)
Published: Jan. 8, 2024
Abstract Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence FBR poses heavy burden on both medical and socioeconomic systems. This review seeks to elucidate protein “fingerprint” implant materials, which generated by physiochemical properties materials themselves. In this review, activity macrophages, formation foreign giant cells (FBGCs), development fibrosis capsules in context are introduced. Additionally, relationship between various elucidated detail, as an overview existing approaches technologies employed alleviate FBR. Finally, significance components (metallic non‐metallic materials), surface CHEMISTRY (charge wettability), physical characteristics (topography, roughness, stiffness) establishing also well documented. conclusion, aims emphasize importance provides current perspectives developing with anti‐FBR properties.
Language: Английский
Citations
19
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 477, P. 147195 - 147195
Published: Nov. 10, 2023
Language: Английский
Citations
26
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 21, 2024
Abstract Periodontitis is a chronic inflammation caused by bacterial infection and intimately associated with an overactive immune response. Biomaterials are being utilized more frequently in periodontal therapy due to their designability unique drug delivery system. However, local systemic response reactions driven the implantation of biomaterials could result inflammation, tissue damage, fibrosis, which end up failure implantation. Therefore, immunological adjustment through precise design can reduce host reaction while eliminating tissue's long-term It important note that macrophages active system component participate progression disease intricate polarization mechanisms. And modulating macrophage designing has emerged as new technique. In this review, we discuss role periodontitis typical strategies for polarizing biomaterials. Subsequently, challenges potential opportunities using manipulate facilitate regeneration. Graphical
Language: Английский
Citations
14
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Bone defects, whether caused by trauma, cancer, infectious diseases, or surgery, can significantly impair people's quality of life. Although autografts are the gold standard for treating bone they often fall short in adequately forming tissue. The field tissue engineering has made strides using scaffolds with various biomaterials, stem cells, and growth factors to enhance healing. However, some biological structures do not yield satisfactory therapeutic outcomes new formation. Recent studies have shed light on crucial role immunomodulation, specifically interaction between implanted scaffold host immune systems, regeneration. Immune particularly macrophages, pivotal inflammatory response, angiogenesis, osteogenesis. This review delves into system's mechanism toward foreign bodies recent advancements scaffolds' physical properties that foster regeneration modulating macrophage polarization an anti-inflammatory phenotype enhancing osteoimmune microenvironment.
Language: Английский
Citations
1
Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 282, P. 111566 - 111566
Published: May 17, 2024
Language: Английский
Citations
6
Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042007 - 042007
Published: April 18, 2024
Bone tissue engineering (BTE) provides the treatment possibility for segmental long bone defects that are currently an orthopedic dilemma. This review explains different strategies, from biological, material, and preparation points of view, such as using stem cells, ceramics, metals, their corresponding properties BTE applications. In addition, factors porosity, surface chemistry, hydrophilicity degradation behavior affect scaffold success introduced. Besides, most widely used production methods result in porous materials discussed. Gene delivery secretome-based therapies also introduced a new generation therapies. outlines positive results important limitations remaining clinical application novel defects.
Language: Английский
Citations
5