Applied Materials Today, Journal Year: 2024, Volume and Issue: 37, P. 102130 - 102130
Published: Feb. 28, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)
Published: May 1, 2024
Abstract The musculoskeletal system, which is responsible for weight‐bearing, movement, and organ protection, faces many disorders arising from injuries, diseases, trauma that affect millions of people worldwide, resulting in a decreased quality life socioeconomic burden. Tissue engineering at the forefront current research on tissue regeneration demonstrates great potential repair. Among numerous grafts available, adhesive hydrogels have demonstrated applications. Despite surge development bioadhesive hydrogel formulations recent years, absence an evaluation protocol their formulation has led to emergence similar products do not fully meet clinical requirements applicability regeneration. This review aims address this gap by first discussing design considerations ideal relevant successful By thoroughly reviewing advances hydrogels, with particular focus applications facilitating repair, improvements are proposed criteria novel applications, several key challenges directions implementation summarized.
Language: Английский
Citations
11
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 17, 2024
Abstract The scaffold that bioinspired natural bone‐periosteum is ideal for the repair of bone defects, while achievement a gradient with an integrated and stable interface remains challenging. Herein, collagen‐based developed, in which top layer electrospun collagen‐dense as periosteum (BP) to prevent invasion reticular fiber tissue bottom situ mineralized collagen (IMCS) promote osteogenic differentiation. Owing proposed continuous manufacturing successive 3D printing electrospinning, (BP‐IMCS) comprised BP IMCS demonstrates excellent structural stability, ten times higher than direct‐combination scaffolds. Besides, vivo implantation results confirmed BP‐IMCS significantly improves new formation up 32.47%, better individual layer, due its co‐work mineral ions structure. Therefore, this study offers strategy realize interface‐stable structure, providing solutions heterostructure fabrication.
Language: Английский
Citations
11
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101099 - 101099
Published: May 22, 2024
Advancements in tissue engineering are crucial for successfully healing tendon-bone connections, especially situations like anterior cruciate ligament (ACL) restoration. This study presents a new and innovative three-dimensional scaffold, reinforced with nanofibers, that is specifically intended acellular tendon complexes. The scaffold consists of distinct layered arrangement comprising an core, middle layer polyurethane (PU)/ type I collagen yarn, outside poly (L-lactic acid)/bioactive glass (PLLA/BG) nanofiber membrane. Every designed to fulfill specific yet harmonious purposes. core solid structural base favorable environment cell functions, resulting considerable tensile strength. central polyurethane/type yarn vital promoting the tendinogenic differentiation stem cells derived from tendons increasing expression critical factors. external PLLA/BG membrane fosters process bone marrow mesenchymal differentiating into enhances markers associated formation. Our scaffold's biocompatibility multi-functional design were confirmed through extensive vivo evaluations, such as histological staining biomechanical analyses. These assessments combined showed notable enhancements ACL repair healing. emphasizes promise multi-layered scaffolds orthopedic also introduces possibilities creation improved materials regenerating interface.
Language: Английский
Citations
9
European Polymer Journal, Journal Year: 2025, Volume and Issue: 224, P. 113718 - 113718
Published: Jan. 4, 2025
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(38), P. 44607 - 44620
Published: Sept. 18, 2023
Bioactive and mechanically stable metal-based scaffolds are commonly used for bone defect repair. However, conventional induce nonuniform cell growth, limiting damaged tissue restoration. Here, we develop a plasma nanotechnology-enhanced graphene quantum dot (GQD) hydrogel-magnesium (Mg) composite scaffold functional repair by integrating bioresource-derived nitrogen-doped GQD (NGQD) hydrogel into the Mg ZK60 alloy. Each component brings major synergistic advantages over current alloy-based state of art, including (1) mechanical support cortical calcium deposition released Mg2+ during degradation; (2) enhanced uptake, migration, distribution osteoblasts porous hydrogel; (3) improved osteoblast adhesion proliferation, osteogenesis, mineralization NGQDs in hydrogel. Through an vivo study, hybrid with much osteogenic ability induced above synergy promotes more rapid, uniform, directional growth across channel, compared control Mg-based scaffold. This work provides insights design multifunctional scaffolds, which can be applied other areas well beyond demonstrated
Language: Английский
Citations
22
Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 523 - 536
Published: Aug. 10, 2024
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(3)
Published: Nov. 3, 2023
The periosteum plays a vital role in the regeneration of critical-size bone defects and highly comminuted fractures, promoting differentiation osteoblasts, accelerating reconstruction vascular network, guiding tissue regeneration. However, materials loaded with exogenous growth factors are limited by release activity elements. Therefore, material structure must be carefully designed for periosteal function. Here, self-adaptive biomimetic strategy is proposed, which novel interpenetrating double network hydrogel consisting diselenide-containing gelatin calcium alginate (modified natural collagen polysaccharide) to enhance stability, anti-swelling, delayed degradation hydrogel. diselenide bond continuously releases nitric oxide (NO) metabolizing endogenous nitrosated thiols (RSNO), activates oxide-cycle guanosine monophosphate (NO-cGMP) signal pathway, coordinates coupling effect angiogenesis osteogenesis, accelerates repair defects. This formed has been proven safe effective repairing expected provide promising solving clinical problems.
Language: Английский
Citations
16
Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 14(1), P. 23 - 23
Published: Dec. 31, 2022
Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new formation, activate cell proliferation, stimulate genetic expression of proteins, trigger unique anti-bacterial, anti-inflammatory, anti-cancer functionalities. Recently, composites based on biopolymers BG have been developed with various state-of-the-art techniques Gelatin, a semi-synthetic biopolymer, has attracted attention researchers because it is derived from most abundant protein in body, viz., collagen. It polymer that be dissolved water processed acquire different configurations, such as hydrogels, fibers, films, scaffolds. Searching "bioactive gelatin" tile Scopus renders 80 highly relevant articles published last ~10 years, which signifies importance composites. First, this review addresses basic concepts engineering, including healing mechanisms limitations ahead. Then, current knowledge gelatin/BG composition, processing properties summarized discussed applications. This explores physical, chemical mechanical features ion-release effects concerning osteogenic angiogenic responses vivo vitro. Additionally, recent developments BG/gelatin using 3D/4D printing engineering presented. Finally, perspectives challenges developing desirable regeneration tissues outlined.
Language: Английский
Citations
22
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(49), P. 54488 - 54499
Published: Dec. 3, 2022
Bioadhesives are widely used in a variety of medical settings due to their ease use and efficient wound closure repair. However, achieving both strong adhesion removability/reusability is highly needed but challenging. Here, we reported an injectable mesoporous bioactive glass nanoparticle (MBGN)-incorporated biopolymer hydrogel bioadhesive that demonstrates strength (up 107.55 kPa) at physiological temperatures also removable reusable. The incorporation MBGNs the significantly enhances tissue adhesive increased cohesive property compared alone. detachment results from temperature-induced weakening interfacial strength. Moreover, displays injectability, self-healing, excellent biocompatibility. We demonstrate potential applications vitro, ex vivo, vivo for hemostasis intestinal leakage accelerated skin healing surgical closures. This work provides novel design bioadhesives.
Language: Английский
Citations
21
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100866 - 100866
Published: Nov. 26, 2023
The significance of the osteogenesis-angiogenesis relationship in healing process bone defects has been increasingly emphasized recent academic research. Surface topography plays a crucial role guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with nanoscale structural and topological features, enabling modulation scaffold physicochemical properties. This study involved loading varying quantities UiO-66 nanocrystals onto alkali-heat treated 3D-printed titanium scaffolds, resulting formation hierarchical micro/nano named UiO-66/AHTs. properties these scaffolds were subsequently characterized. Furthermore, impact on osteogenic potential BMSCs, angiogenic HUVECs, their intercellular communication investigated. findings this indicated that 1/2UiO-66/AHT outperformed other groups terms induction, as well promoting crosstalk by enhancing paracrine effects. These results suggest promising biomimetic design facilitates coupling osteogenesis angiogenesis.
Language: Английский
Citations
13