Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(2)
Published: Feb. 1, 2024
Abstract
Hydrogels
find
diverse
applications
in
manipulating
bacteria,
and
serving
purposes
like
elevation,
maintenance,
elimination.
Several
factors
of
hydrogel
have
been
studied
the
benefits
antibacterial
activity.
Factors
such
as
stiffness
roughness
gain
significance
surface
coating,
influencing
bacterial
behavior.
However,
intricate
interplay
stiffness,
roughness,
polymer
types,
species
necessitates
further
exploration.
The
choice
is
dictated
by
specific
objectives,
particularly
scenarios
where
polymers
with
positive
charge,
hydrophilicity,
acidity
prove
effective.
These
properties
induce
robust
electrostatic
hydrophobic/hydrophilic
interactions,
along
pH‐induced
cell
membrane
damage,
collectively
contributing
to
hindered
adhesion
growth.
Additionally,
extracellular
polymeric
substances
(EPS)
emerge
pivotal
influencers
proliferation.
EPS
production
alters
surfaces,
fostering
connections
between
bacteria
facilitating
biofilm
formation.
hydrophobic
nature
complicates
interactions
materials,
emphasizing
nuanced
hydrophilic
forces
adhesion.
Herein,
this
work
article
has
reviewed
related
study
each
physical
property
on
hydrogel.
Moreover,
also
illustrates
for
medical
treatment,
including
wound
healing,
food
packaging,
coating.
growing
engineered
living
updated
various
applications.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1172 - 1172
Published: March 6, 2024
Implant-associated
infections
(IAIs)
represent
a
major
health
burden
due
to
the
complex
structural
features
of
biofilms
and
their
inherent
tolerance
antimicrobial
agents
immune
system.
Thus,
viable
options
eradicate
embedded
on
medical
implants
are
surgical
operations
long-term
repeated
antibiotic
courses.
Recent
years
have
witnessed
growing
interest
in
development
robust
reliable
strategies
for
prevention
treatment
IAIs.
In
particular,
it
seems
promising
develop
materials
with
anti-biofouling
antibacterial
properties
combating
IAIs
implants.
this
contribution,
we
exclusively
focus
recent
advances
modified
functionalized
implant
surfaces
inhibiting
bacterial
attachment
eventually
biofilm
formation
orthopedic
Further,
highlight
progress
coatings
(including
self-assembled
nanocoatings)
preventing
Among
recently
introduced
approaches
efficient
durable
coatings,
use
safe
biocompatible
excellent
activities
local
delivery
combinatorial
treating
overcoming
resistance.
Cancer Cell International,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Nov. 19, 2023
Gastrointestinal
(GI)
cancer
is
a
major
health
problem
worldwide,
and
current
diagnostic
therapeutic
approaches
are
often
inadequate.
Various
metallic
nanoparticles
(MNPs)
have
been
widely
studied
for
several
biomedical
applications,
including
cancer.
They
may
potentially
overcome
the
challenges
associated
with
conventional
chemotherapy
significantly
impact
overall
survival
of
GI
patients.
Functionalized
MNPs
targeted
ligands
provide
more
efficient
localization
tumor
energy
deposition,
better
solubility
stability,
specific
targeting
properties.
In
addition
to
enhanced
efficacy,
also
tool
molecular
imaging
malignant
lesions,
enabling
non-invasive
or
detection
tumor-specific
tumor-associated
antigens.
MNP-based
systems
enable
simultaneous
stability
encapsulated
drugs
regulate
delivery
agents
directly
cells,
which
improves
efficacy
minimizes
drug
toxicity
leakage
into
normal
cells.
However,
metal
shown
cytotoxic
effect
on
cells
in
vitro.
This
can
be
concern
when
using
treatment,
as
they
kill
healthy
this
review,
we
an
overview
state
field,
preparation
methods
MNPs,
clinical
advances
their
use
therapy,
well
advantages
limitations
diagnosis
treatment
gastrointestinal
such
potential
toxicity.
We
discuss
future
directions
areas
further
research,
development
novel
optimization
existing
approaches.
Stem Cell Research & Therapy,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 19, 2023
Abstract
Peripheral
nerve
injury
(PNI)
is
one
of
the
public
health
concerns
that
can
result
in
a
loss
sensory
or
motor
function
areas
which
injured
and
non-injured
nerves
come
together.
Up
until
now,
there
has
been
no
optimized
therapy
for
complete
regeneration
after
PNI.
Exosome-based
therapies
are
an
emerging
effective
therapeutic
strategy
promoting
functional
recovery.
Exosomes,
as
natural
extracellular
vesicles,
contain
bioactive
molecules
intracellular
communications
nervous
tissue
function,
could
overcome
challenges
cell-based
therapies.
Furthermore,
bioactivity
ability
exosomes
to
deliver
various
types
agents,
such
proteins
microRNA,
have
made
potential
approach
neurotherapeutics.
However,
type
cell
origin,
dosage,
targeted
delivery
still
pose
clinical
translation
exosome
therapeutics.
In
this
review,
we
focused
on
Schwann
mesenchymal
stem
(MSC)-derived
regeneration.
Also,
expressed
current
understanding
MSC-derived
related
provided
insights
developing
cell-free
MSC
injury.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 14, 2024
Abstract
This
review
highlights
recent
advancements
in
the
synthesis,
processing,
properties,
and
applications
of
2D‐material
integrated
hydrogels,
with
a
focus
on
their
performance
bone‐related
applications.
Various
synthesis
methods
types
2D
nanomaterials,
including
graphene,
graphene
oxide,
transition
metal
dichalcogenides,
black
phosphorus,
MXene
are
discussed,
along
strategies
for
incorporation
into
hydrogel
matrices.
These
composite
hydrogels
exhibit
tunable
mechanical
high
surface
area,
strong
near‐infrared
(NIR)
photon
absorption
controlled
release
capabilities,
making
them
suitable
range
regeneration
therapeutic
In
cancer
therapy,
2D‐material‐based
show
promise
photothermal
photodynamic
therapies,
drug
delivery
(chemotherapy).
The
properties
these
materials
enable
selective
tumor
ablation
upon
NIR
irradiation,
while
drug‐loading
capacity
facilitates
targeted
chemotherapeutic
agents.
Additionally,
2D‐materials
‐infused
potent
antibacterial
activity,
effective
against
multidrug‐resistant
infections
disruption
biofilm
generated
implant
surface.
Moreover,
synergistic
therapy
approach
combines
multiple
treatment
modalities
such
as
photothermal,
chemo,
immunotherapy
to
enhance
outcomes.
bio‐imaging,
serve
versatile
contrast
agents
imaging
probes,
enabling
real‐time
monitoring
during
imaging.
Furthermore,
bone
regeneration,
most
incorporated
promote
osteogenesis
tissue
offering
potential
solutions
defects
repair.
Overall,
integration
presents
promising
platform
developing
multifunctional
theragenerative
biomaterials.
