Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: June 2, 2024
Abstract
Hydrogels
are
dynamically
evolving
3D
networks
composed
of
hydrophilic
polymer
scaffolds
with
significant
applications
in
the
healthcare
and
environmental
sectors.
Notably,
protein‐based
hydrogels
mimic
extracellular
matrix,
promoting
cell
adhesion.
Further
enhancing
proliferation
within
these
matrix‐metalloproteinase‐triggered
amino
acid
motifs.
Integration
cell‐friendly
modules
like
peptides
proteins
expands
hydrogel
functionality.
These
exceptional
properties
position
for
diverse
applications,
including
biomedicine,
biosensors,
remediation,
food
industry.
Despite
progress,
there
is
ongoing
research
to
optimize
biomedical
further.
Engineering
novel
favorable
characteristics
crucial
regulating
tissue
architecture
facilitating
ecological
remediation.
This
review
explores
synthesis,
physicochemical
properties,
biological
implications
various
types
their
extensive
biomedicine
It
elaborates
on
potential
bridging
gap
between
advancements
sector
solutions
issues.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
The
hydrogel
adhesives
with
strong
tissue
adhesion
and
biological
characteristics
adhm202404447are
urgently
needed
for
injury
sealing
repair.
However,
the
negative
correlation
between
mechanical
strength
poses
a
challenge
their
practical
application.
Herein,
bio‐inspired
cohesive
enhancement
strategy
is
developed
to
prepare
adhesive
simultaneously
enhanced
adhesion.
double
cross‐linked
network
achieved
through
cooperation
polyacrylic
acid
grafted
N‐hydroxy
succinimide
crosslinked
by
tannic
cohesion‐enhanced
ion
crosslinking
of
sodium
alginate
Ca
2+
.
Such
unique
structure
endows
resultant
excellent
strength.
capable
various
organs
in
vitro,
exhibits
satisfactory
on‐demand
removability,
antibacterial,
antioxidant
properties.
As
proof
concept,
not
only
effectively
halts
non‐compressible
hemorrhages
beating
heart
femoral
artery
models
rats,
but
also
accelerates
healing
infected
wound
inhibiting
bacteria
reducing
inflammation.
Overall,
this
advanced
promising
as
an
emergency
rescue
that
enables
robust
closure,
timely
controlling
bleeding,
promoting
damaged
healing.
