Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 20, 2025
Salmonella
is
one
of
the
most
common
foodborne
pathogens,
which
can
cause
severe
enteritis
and
intestinal
microbiota
imbalance.
However,
there
are
limited
strategies
currently
available
for
preventing
or
treating
Salmonella-induced
colitis.
Herein,
we
developed
Cu/Mn-co-doped
ZnO
tandem
nanozyme
(ZnO-CM)
with
pH-responsive
multienzyme-mimicking
activities
via
doping
engineering
treatment
Benefiting
from
co-doping
Cu
Mn,
ZnO-CM
nanospheres
exhibit
remarkable
peroxidase-like
activity
in
acidic
condition
superoxide
dismutase-
catalase-like
neutral
environment.
Animal
experiments
show
that
efficiently
inhibit
bacterial
growth,
alleviate
inflammation,
restore
barrier,
resulting
good
antibacterial
anti-inflammatory
effects
on
Mechanistically,
functions
through
inhibiting
continuous
accumulation
ROS,
increasing
levels
tight
junction
proteins
occludin
claudin-1,
decreasing
expression
pro-inflammatory
cytokines
IL-1β
IL-6
intestine.
This
work
not
only
presents
an
effective
paradigm
colitis
therapy,
but
also
provides
new
sights
into
prevention
other
enteritis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: April 14, 2024
Although
nanozymes
have
drawn
great
attention
over
the
past
decade,
activities
of
peroxidase-like,
oxidase-like,
and
catalase-like
are
often
pH
dependent
with
elusive
mechanism,
which
largely
restricts
their
application.
Therefore,
a
systematical
discussion
on
pH-related
catalytic
mechanisms
together
methods
to
overcome
this
limitation
is
in
need.
In
review,
various
exhibiting
pH-dependent
collected
root
causes
for
dependence
comprehensively
analyzed.
Subsequently,
regulatory
concepts
including
environment
reconstruction
direct
activity
improvement
break
restriction
summarized.
Moreover,
applications
pH-independent
sensing,
disease
therapy,
pollutant
degradation
overviewed.
Finally,
current
challenges
future
opportunities
development
suggested.
It
anticipated
that
review
will
promote
further
design
broaden
application
range
higher
efficiency.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(29), P. 6746 - 6761
Published: Jan. 1, 2023
The
slow
healing
of
diabetic
wounds
has
seriously
affected
human
health.
Meanwhile,
the
open
are
susceptible
to
bacterial
infection.
Clinical
therapeutic
methods
such
as
antibiotic
therapy,
insulin
treatment,
and
surgical
debridement
have
made
great
achievements
in
treatment
wounds.
However,
drug-resistant
bacteria
will
develop
after
long-term
use
antibiotics,
resulting
decreased
efficacy.
To
improve
effect,
increasing
drug
concentration
is
a
common
strategy
clinical
practice,
but
it
also
brings
serious
side
effects.
In
addition,
hyperglycemia
control
or
can
easily
bring
negative
effects
patients,
hypoglycemia
damage
normal
tissue.
Therefore,
essential
novel
strategies
effectively
promote
wound
healing.
recent
years,
nanozyme-based
systems
received
extensive
attention
because
they
possess
advantages
nanomaterials
natural
enzymes.
For
example,
nanozymes
small
size
high
surface
area
volume
ratio,
which
enhance
tissue
penetration
increase
reactive
active
sites.
Moreover,
compared
with
enzymes,
more
stable
catalytic
activity,
lower
production
cost,
stronger
operability.
this
review,
we
first
reviewed
basic
characteristics
then
elaborated
on
mechanism
action
principle
different
types
from
three
aspects:
controlling
infection,
hyperglycemia,
relieving
inflammation.
Finally,
challenges,
prospects
future
implementation
for
outlined.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Small Structures,
Journal Year:
2024,
Volume and Issue:
5(6)
Published: March 25, 2024
Traditional
antibacterial
agents
are
often
observed
to
be
ineffective
because
bacteria
evolved
strains
with
greater
antibiotic
resistance.
Here,
vigorous
chitosan‐stabilized
PtAu
nanoparticles
(CSPA)
multienzyme‐like
activity
successfully
fabricated,
which
serve
an
effective
artificial
nanozyme
enhance
for
mixed
bacterial
infection
wound
treatment.
Ultrasmall
size
CSPA
exhibits
excellent
hydrophilicity
and
biocompatibility,
possesses
strong
oxidase‐
peroxidase‐like
generating
a
substantial
amount
of
ROS
(,
1
O
2
,
·OH)
cause
oxidative
damage
bacteria,
also
demonstrates
nicotinamide
adenine
dinucleotide
dehydrogenase‐like
disrupting
the
respiratory
chains,
subsequently
impedes
adenosine
triphosphate
production.
favorable
broad‐spectrum
at
very
low
concentrations,
prevents
resistance,
completely
inhibits
biofilm
formation.
Antibacterial
Mechanism
by
transcriptomics
is
further
revealed
that
can
induce
stress,
hinder
energy
metabolism,
disrupt
synthesis
function
cell
walls
membranes.
In
vivo,
population
site
promotes
healing
in
rats.
This
study
introduces
novel
approach,
providing
important
insight
into
mechanism
nanozymes
promoting
advancement
nanocatalytic
materials
biomedical
applications.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 6, 2024
Abstract
Nanozyme,
characterized
by
outstanding
and
inherent
enzyme-mimicking
properties,
have
emerged
as
highly
promising
alternatives
to
natural
enzymes
owning
their
exceptional
attributes
such
regulation
of
oxidative
stress,
convenient
storage,
adjustable
catalytic
activities,
remarkable
stability,
effortless
scalability
for
large-scale
production.
Given
the
potent
regulatory
function
nanozymes
on
stress
coupled
with
fact
that
reactive
oxygen
species
(ROS)
play
a
vital
role
in
occurrence
exacerbation
metabolic
diseases,
nanozyme
offer
unique
perspective
therapy
through
multifunctional
achieving
essential
results
treatment
diseases
directly
scavenging
excess
ROS
or
regulating
pathologically
related
molecules.
The
rational
design
strategies,
nanozyme-enabled
therapeutic
mechanisms
at
cellular
level,
therapies
several
typical
underlying
are
discussed,
mainly
including
obesity,
diabetes,
cardiovascular
disease,
diabetic
wound
healing,
others.
Finally,
pharmacokinetics,
safety
analysis,
challenges,
outlooks
application
also
presented.
This
review
will
provide
some
instructive
perspectives
promote
development
strategies
disease
therapy.
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