Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 22, 2025
Abstract
Cathepsin
S
(CatS)
is
a
lysosomal
enzyme
belonging
to
the
papain
family
of
cysteine
proteases.
Studies
have
demonstrated
that
CatS
plays
pivotal
role
in
antigen
presentation
and
associated
with
Alzheimer's
disease,
atherosclerosis,
obesity,
positioning
it
as
potential
target
related
disorders.
Consequently,
development
selective
straightforward
method
for
detecting
crucial.
In
this
study,
we
introduce
colorimetric
approach
utilizing
gold
nanoparticles
(AuNPs)
CatS‐specific
peptides
detection
activity.
The
cleavage
peptides,
PMGAPC
or
PMGAPC‐NH
2
,
can
stabilize
AuNPs
hydrosaline
solution
without
aggregation.
Upon
hydrolysis
by
CatS,
aggregate
color
change
from
red
blue.
After
optimizing
size
concentration
limits
were
both
be
10
nM,
when
used
protect
AuNPs.
Therefore,
assay,
which
employs
AuNPs,
enables
not
only
but
also
simple
visible
naked
eye.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Gold
nanoparticles
(AuNPs)
have
outstanding
catalytic
properties,
whereas
their
broader
application
is
hindered
by
limited
charge
transport
and
stability.
In
this
work,
we
present
a
simple
rapid
synthesis
method
for
immobilizing
AuNPs
onto
filters
using
polythiourea,
aimed
at
facilitating
enhancing
the
conversion
of
2-nitrophenol
in
aqueous
solutions.
The
results
show
an
obvious
enhancement
performance
when
immobilized
filter
paper
with
reducing
complete
time
from
14
min
to
150
s.
optimal
addition
amount
polythiourea
5.0
mL.
Additionally,
kinetics
recyclability
system
were
investigated;
it
was
observed
that
even
after
15
cycles
testing,
on
maintained
consistently
These
findings
suggest
promising
strategy
extending
functional
lifespan
while
offering
platform
reactions.
Sensors & Diagnostics,
Journal Year:
2024,
Volume and Issue:
3(9), P. 1522 - 1532
Published: Jan. 1, 2024
We
demonstrated
a
WS
2
QDs-induced
fluorescence
probe
for
monitoring
ofloxacin
(OFL)
and
ciprofloxacin
(CIP)
in
water
the
range
of
0–3
μM,
showing
enhanced
fluorescence,
high
sensitivity
anti-interference
ability.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(7), P. 347 - 347
Published: July 17, 2024
This
study
aimed
to
develop
a
novel
fluorescent
aptasensor
for
the
quantitative
detection
of
zearalenone
(ZEN),
addressing
limitations
conventional
techniques
in
terms
speed,
sensitivity,
and
ease
use.
Nitrogen-doped
carbon
dots
(N-CDs)
were
synthesized
via
hydrothermal
method,
resulting
spherical
particles
with
diameter
3.25
nm.
These
N-CDs
demonstrated
high
water
solubility
emitted
bright
blue
light
at
440
nm
when
excited
355
The
fluorescence
was
quenched
by
dispersed
gold
nanoparticles
(AuNPs)
through
inner
filter
effect,
while
aggregated
AuNPs
induced
NaCl
did
not
affect
N-CDs.
aptamer
could
protect
from
NaCl-induced
aggregation,
but
presence
ZEN
weakened
this
protective
effect.
Based
on
principle,
optimal
conditions
included
57
mM
NaCl,
12.5
nM
concentration,
incubation
15
min
Tris-EDTA(TE)
buffer,
30
min.
Under
these
optimized
conditions,
"signal-on"
showed
linear
range
0.25
200
ng/mL
low
limit
0.0875
ng/mL.
Furthermore,
developed
exhibited
excellent
specificity
rapidly
detect
corn
flour
samples
or
oil,
achieving
satisfactory
recovery
rates
ranging
84.7%
108.6%.
Therefore,
presents
an
economical,
convenient,
sensitive,
rapid
method
accurately
quantifying
cereal
products.
