Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 24, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(28)
Published: March 12, 2024
Abstract Diabetes mellitus (DM) is characterized by elevated blood glucose and advanced glycation end product (AGEs) levels. Increased AGEs in bone tissue inhibit osteogenic differentiation marrow mesenchymal stem cells (BMSCs), leading to loss osteoporosis diabetic patients. Enhancing the capacity of BMSCs presence abundant can improve health prevent DM The flavonoid, Quercetin, has anti‐inflammatory, antibacterial, antitumor properties; however, it insoluble water thus not easily absorbed body. Nanodrug delivery systems such as tetrahedral framework nucleic acids (tFNAs) exhibit excellent biocompatibility, efficient cell uptake, drug piggybacking. In present study, tFNAs with quercetin complexed form a novel nanodrug (tFNAs/Que) that combined features both components. tFNAs/Que promote an vitro AGEs‐rich environment, maintain mass, mice vivo. mechanism against may be related JNK signaling pathway. conclusion, shown dual regulatory role promoting inhibiting apoptosis. Such feature promising for prevention treatment osteoporosis.
Language: Английский
Citations
31
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 187 - 187
Published: Jan. 15, 2024
In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize
Language: Английский
Citations
18
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 524 - 538
Published: Feb. 12, 2025
Receptor-mediated endocytosis plays a crucial role in the success of numerous therapies and remains central to advancing drug development. This process begins with ligand binding specific receptors, triggering internalization intracellular trafficking receptor-ligand complexes. These complexes are subsequently directed into distinct routes, either toward lysosomal degradation or recycling cell surface, implications for therapeutic outcomes. review examines interactions as key modulators endocytosis, emphasizing their shaping design efficacy. Advances selecting pairs engineering ligands optimized properties have enabled precise control over internalization, endosomal sorting, trafficking, providing tailored solutions diverse applications. Leveraging these insights, strategies such RNA-based therapies, antibody-drug conjugates (ADCs), targeted protein (TPD) platforms been refined selectively avoid promote degradation, thereby enhancing By bridging fundamental mechanisms receptor-mediated innovative approaches, this offers framework precision medicine.
Language: Английский
Citations
3
JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 486 - 520
Published: Feb. 10, 2025
Tetrahedral framework nucleic acids (tFNAs) represent a promising advancement in acid nanotechnology due to their unique structural properties, high biocompatibility, and multifaceted biomedical applications. Constructed through one-pot annealing method, four single-stranded DNAs self-assemble into stable, three-dimensional tetrahedral nanostructures with enhanced mechanical robustness physiological stability, resisting enzymatic degradation. Their ability permeate mammalian cells without transfection agents, coupled modifiable surfaces, positions tFNAs as versatile carriers for drug gene delivery systems. The tFNA-based platforms exhibit superior therapeutic efficacy, including antioxidative anti-inflammatory effects, alongside efficient cellular uptake tissue penetration. These features underpin role precision medicine, enabling targeted of diverse agents such synthetic compounds, peptides, acids. Additionally, demonstrate significant potential regenerative immune modulation, antibacterial strategies, oncology. By addressing challenges translational integration, stand poised accelerate the development research clinical applications, fostering novel therapies enhancing outcomes across wide spectrum diseases. This Perspective thoroughly details attributes applications critically evaluates tFNAs' potential, outlining inherent implementation exploring solutions these obstacles.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 7, 2024
Abstract DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating the spatial arrangement of molecular components, such biomolecules, antibodies, or synthetic This is achieved by incorporating oligonucleotides into design nanostructure. In realm drug delivery to cancer cells, there a growing interest active targeting assays enhance efficacy selectivity. The approach involves “key‐lock” mechanism where carrier, through its ligand, recognizes specific receptors on tumor facilitating release drugs. Various nanostructures, including origami, Tetrahedral, nanoflower, cruciform, nanostar, nanocentipede, nanococklebur, can traverse lipid layer cell membrane, allowing cargo nucleus. Aptamers, easily formed vitro, are recognized their targeted due high selectivity targets low immunogenicity. review provides comprehensive overview recent advancements formation modification aptamer‐modified within systems.
Language: Английский
Citations
15
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(18), P. 6947 - 6957
Published: April 24, 2024
Life-threatening allergic reactions to food allergens, particularly peanut protein Ara h1, are a growing public health concern affecting millions of people worldwide. Thus, accurate and rapid detection is necessary for allergen labeling dietary guidance ultimately preventing incidents. Herein, we present novel ratiometric fluorescence aptasensor based on multivalent aptamer-encoded DNA flowers (Mul-DNFs) the high-stability sensitive h1. The flower-shaped Mul-DNFs were spontaneously packaged using ultralong polymeric amplicons driven by rolling circle amplification reaction, which contains large number h1 specific recognition units has excellent binding properties. Furthermore, dual-color fluorescence-labeled probes developed hybridizing them with Cy3- Cy5-labeled complementary (cDNA) serve as platform resonance energy transfer. Benefiting from combined merits extraordinary synergistic ability Mul-DNFs, specificity aptamer, sensitivity sensor avoid exogenous interference. showed linearity (0.05–2000 ng mL–1) limit 0.02 mL–1. Additionally, was utilized quantifying presence in milk, infant milk powder, cookies, bread, chocolate recoveries 95.7–106.3%. proposed expected be prospective universal rapid, sensitive, determination environmental hazards.
Language: Английский
Citations
14
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134187 - 134187
Published: Aug. 3, 2024
Language: Английский
Citations
9
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106614 - 106614
Published: Jan. 1, 2025
Language: Английский
Citations
1
International Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 5(1), P. 6 - 6
Published: Jan. 10, 2025
The ATP-binding cassette (ABC) transporter superfamily, one of the largest membrane protein families, plays a crucial role in multidrug resistance (MDR) cancer by mediating efflux various chemotherapeutic agents, thereby lowering their intracellular concentrations and diminishing therapeutic effectiveness. Beyond drug efflux, these transporters are also involved vital biological processes, such as signal transduction cancer. Over past few decades, extensive structural functional research has provided valuable insights into ABC transporters’ broad substrate specificity transport mechanisms, leading to promising strategies for overcoming MDR. This review will provide understanding interactions between inhibitors develop novel therapeutics. Additionally, we focus on methods irradiation-based immune therapies, thermal nanomedicine, CRISPR-Cas, natural therapies that can genetically modify reduce expression or reverse ability. Knowledge gained from approaches then be translated development new therapeutics combat chemotherapy resistance.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 4, 2024
Abstract Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), remains a highly lethal malignancy with limited therapeutic options and dismal prognosis. By targeting the underlying molecular abnormalities responsible for PDAC development progression, gene therapy offers promising strategy to overcome challenges posed by conventional radiotherapy chemotherapy. This study sought explore potential of small activating RNAs (saRNAs) specifically CCAAT/enhancer-binding protein alpha ( CEBPA ) in PDAC. To associated saRNA delivery, tetrahedral framework nucleic acids (tFNAs) were rationally engineered as nanocarriers. These tFNAs further functionalized truncated transferrin receptor aptamer (tTR14) enhance specificity cells. The constructed tFNA-based formulation demonstrated exceptional stability, efficient release ability, substantial cellular uptake, biocompatibility, nontoxicity. In vitro experiments revealed successful intracellular delivery -saRNA utilizing tTR14-decorated tFNA nanocarriers, resulting significant activation tumor suppressor genes, namely, its downstream effector P21 , leading notable inhibition cell proliferation. Moreover, mouse model PDAC, tFNA-mediated effectively upregulated expression consequently suppressing growth. compelling findings highlight utility delivered via designed nanocarrier induce genes an innovative approach
Language: Английский
Citations
6