International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135932 - 135932
Published: Sept. 1, 2024
Language: Английский
Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 266 - 282
Published: Jan. 25, 2025
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36258 - e36258
Published: Aug. 1, 2024
Natural bone tissue has the certain function of self-regeneration and repair, but it is difficult to repair large damage. Recently, although autologous grafting "gold standard" for improving high cost, few donor sources. Besides, allogeneic causes greater immune reactions, which hardly meet clinical needs. The engineering (BTE) been developed promote repair. Gelatin, due its biocompatibility, receives a great deal attention in BTE research field. However, disadvantages natural gelatin are poor mechanical properties single structural property. With development BTE, often used combination with range natural, synthetic polymers, inorganic materials achieve synergistic effects complex physiological process review delves into fundamental structure unique gelatin, as well excellent necessary scaffold materials. Then this explores application modified three-dimensional (3D) scaffolds various structures including 3D fiber scaffolds, hydrogels, nanoparticles. In addition, focuses on efficacy composite consisting or polymeric materials, bioactive ceramics metallic/non-metallic defects. these gelatin-based provides new ideas design good biosafety.
Language: Английский
Citations
15
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing
Language: Английский
Citations
1
Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123194 - 123194
Published: Feb. 17, 2025
Language: Английский
Citations
1
Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122885 - 122885
Published: Oct. 10, 2024
Language: Английский
Citations
7
JACS Au, Journal Year: 2024, Volume and Issue: 4(6), P. 2381 - 2392
Published: May 30, 2024
Extracellular vesicles (EVs) are naturally occurring secreted by cells that can transport cargo between cells, making them promising bioactive nanomaterials. However, due to the complex and heterogeneous biological characteristics, a method for robust EV manipulation efficient delivery is still lacking. Here, we developed novel class of extracellular vesicle spherical nucleic acid (EV-SNA) nanostructures with scalability, programmability, cellular delivery. EV-SNA was constructed through simple hydrophobic coassembly natural EVs cholesterol-modified oligonucleotides be stable 1 month at room temperature. Based on programmable shells, respond AND logic gates achieve assembly manipulation. Importantly, from wide range sources EV, enhancing capability nearly 10–20 times. Compared artificial liposomal SNA, endogenous exhibited better biocompatibility more effective antisense in hard-to-transfect primary stem cells. Additionally, deliver functional immune regulation. As material form, may provide modular framework paradigm EV-based applications drug delivery, disease treatment, nanovaccines, other fields.
Language: Английский
Citations
4
Biotechnology Advances, Journal Year: 2024, Volume and Issue: 76, P. 108436 - 108436
Published: Aug. 28, 2024
Language: Английский
Citations
4
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 155 - 177
Published: Sept. 8, 2024
Language: Английский
Citations
4
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mineral density and heightened risk of fractures. Therapies for OP have primarily focused on balancing formation resorption, but enhancing the remineralization osteoporotic also key strategy effective repair. Recent insights into biomineralization mechanisms highlighted essential role mineral-containing extracellular vesicles (EVs) secreted osteoblasts in promoting marrow mesenchymal stromal/stem cell (BMSC) differentiation initiating matrix mineralization. Drawing from these principles, we developed biomimetic approach to replicate structure function osteoblast-derived EVs engineering mitochondrial minerals with homing membranes (CMs). This bone-targeted system exhibits excellent biocompatibility, osteogenic stimulating angiogenesis regulating cellular energy metabolism. Additionally, CM-coated shows affinity collagen fibrils, effectively intrafibrillar mineralization, thereby facilitating Overall, offers safe efficient therapeutic alternative, positioning it as platform tissue regenerative medicine.
Language: Английский
Citations
0
Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
ABSTRACT This study aimed to clarify the role and mechanism of tetrahedral framework nucleic acids (tFNAs) in regulating M2 macrophages reduce intestinal injury. An injury model was established by intraperitoneal injection lipopolysaccharides (LPS) mice explore alleviating effects tFNAs on Inflammatory factors were detected quantitative polymerase chain reaction (qPCR) enzyme‐linked immunosorbent assay (ELISA). The barrier permeability assessed using western blotting immunohistochemistry. Macrophages gut localised quantified immunofluorescence. Western used investigate inflammation injured intestines. These results show that attenuated sepsis‐induced can also promote reconstruction permeability. In vivo, accelerated aggregation at an early stage reduced number M1 intestine. addition, enhanced clearance ability macrophages. They activated signalling transcription activating factor 1(STAT1) cytokine inhibitory 1/3 (SOCS1/3) pathways increasing expression phagocytic receptor Mertk. findings indicated alleviate macrophages, providing a new option for treating
Language: Английский
Citations
0