Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2(4)
Published: Nov. 1, 2024
Abstract
Magnetic
microparticles
(MPs)
and
nanoparticles
(NPs)
have
long
been
used
as
ideal
miniaturized
delivery
detection
platforms.
Their
use
micro‐
nanorobots
(MNRs)
is
also
emerging
in
the
recent
years
with
help
of
more
dedicated
external
magnetic
field
manipulations.
In
this
review,
we
summarize
research
progress
on
nanoparticle
(MNP)‐based
MNRs.
First,
fabrication
from
either
template‐assisted
NP
doping
methods
or
directly
synthesized
MPs
summarized.
The
driving
torque
sources
for
both
types
MNRs
are
analyzed,
their
propulsion
control
under
low
Reynolds
number
flows
discussed
by
evaluating
symmetry
breaking
mechanisms
interparticle
interactions.
Subsequently,
these
scientific
models,
bioimaging
agents,
active
delivery,
treatment
platforms
(drug
cell
sterilization),
biomedical
diagnostics
has
reviewed.
Finally,
perspective
MNPs‐based
was
outlined,
including
challenges
future
directions.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 21, 2024
Medical
microrobotics
is
an
emerging
field
to
revolutionize
clinical
applications
in
diagnostics
and
therapeutics
of
various
diseases.
On
the
other
hand,
mobile
has
important
obstacles
pass
before
translation.
This
article
focuses
on
these
challenges
provides
a
roadmap
medical
microrobots
enable
their
use.
From
concept
"magic
bullet"
physicochemical
interactions
complex
biological
environments
applications,
there
are
several
translational
steps
consider.
Clinical
translation
only
possible
with
close
collaboration
between
experts
researchers
address
technical
microfabrication,
safety,
imaging.
The
application
potential
can
be
materialized
by
designing
that
solve
current
main
challenges,
such
as
actuation
limitations,
material
stability,
imaging
constraints.
strengths
weaknesses
progress
discussed
for
near
future
outlined.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(15), P. 17151 - 17192
Published: July 24, 2024
The
advancement
of
precision
medicine
in
modern
biomedicine
has
been
significantly
propelled
by
the
emergence
micro/nanorobots.
combination
micro/nanorobots
and
offers
unique
advantages
holds
attractive
potential
for
applications.
It
effectively
addresses
challenges
encountered
traditional
robots
areas
such
as
driving,
sensing,
intelligence
other
aspects,
especially
application
cancer
cardiovascular
diseases,
which
is
a
hot
field
interdisciplinary
research
recent
years.
This
review
succinctly
delineates
analyzes
advancements
First,
achievements
years
are
systematically
classified
introduced
from
four
perspectives:
manufacturing
design,
drive
control,
biomedical
degradation.
In
particular,
in-depth
discussions
were
conducted
regarding
solutions
each
stage.
Second,
based
on
latest
results
applications,
development
direction
industrial
applications
key
technical
aspects
that
need
to
be
paid
attention
emphasized.
Finally,
we
discuss
opportunities
future,
it
expected
will
become
more
sophisticated
capable
performing
multiple
medical
functions
tasks.
They
implemented
vivo
assist
doctors
diagnosing
treating
diseases.
shows
significant
medicine.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4678 - 4678
Published: April 25, 2024
Inspired
by
nature’s
remarkable
ability
to
form
intricate
minerals,
researchers
have
unlocked
transformative
strategies
for
creating
next-generation
biosensors
with
exceptional
sensitivity,
selectivity,
and
biocompatibility.
By
mimicking
how
organisms
orchestrate
mineral
growth,
biomimetic
bioinspired
materials
are
significantly
impacting
biosensor
design.
Engineered
offer
distinct
advantages
over
their
natural
counterparts,
boasting
superior
tunability,
precise
controllability,
the
integrate
specific
functionalities
enhanced
sensing
capabilities.
This
versatility
enables
construction
of
various
biosensing
platforms,
including
optical
sensors,
electrochemical
magnetic
biosensors,
nucleic
acid
detection
diverse
applications.
Additionally,
facilitate
development
smartphone-assisted
offering
user-friendly
portable
diagnostic
tools
point-of-care
review
comprehensively
explores
utilization
naturally
occurring
engineered
biominerals
We
highlight
fabrication
design
that
tailor
address
needs.
in-depth
exploration
underscores
potential
in
revolutionizing
biosensing,
paving
way
advancements
healthcare,
environmental
monitoring,
other
critical
fields.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(4), P. 311 - 311
Published: March 26, 2024
Magnetic
robots
possess
an
innate
ability
to
navigate
through
hard-to-reach
cavities
in
the
human
body,
making
them
promising
tools
for
diagnosing
and
treating
diseases
minimally
invasively.
Despite
significant
advances,
development
of
with
desirable
locomotion
full
biocompatibility
under
harsh
physiological
conditions
remains
challenging,
which
put
forward
new
requirements
magnetic
robots’
design
material
synthesis.
Compared
that
are
synthesized
inorganic
materials,
natural
organisms
like
cells,
bacteria
or
other
microalgae
exhibit
ideal
properties
vivo
applications,
such
as
biocompatibility,
deformability,
auto-fluorescence,
self-propulsion,
well
easy
functional
therapeutics
engineering.
In
process,
these
can
provide
autonomous
propulsion
biological
fluids
external
fields,
while
retaining
their
functionalities
integrating
artificial
robots,
thus
aiding
targeted
therapeutic
delivery.
This
kind
robotics
is
named
bio-hybrid
robotics,
this
mini-review,
recent
progress
including
design,
engineering
potential
delivery
will
be
discussed.
Additionally,
historical
context
prominent
examples
introduced,
complexities,
pitfalls,
opportunities
associated
ACS Catalysis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 2236 - 2249
Published: Jan. 23, 2025
Surface-displayed
whole-cell
biocatalysis
offers
significant
advantages
over
traditional
intracellular
enzyme-based
methods
but
faces
challenges
in
complex
multienzyme
processes
and
low
efficiency.
We
present
Scaffold-Mediated
Assembly
Regulation
Tool
(SMART),
a
programmable
platform
for
dynamic
control
of
biocatalysts
on
Corynebacterium
glutamicum
surfaces.
SMART
integrates
orthogonal
cross-linked
scaffolds
with
the
twin
Catcher/Tag
pairs
(SpyCatcher/SpyTag
SnoopCatcher/SnoopTag),
controllable
molecular
ratios,
high
loading
capacity,
offering
user-defined
functionality
enzyme
assembly.
optimized
through
computational
modeling
experimental
validation
created
bifunctional
long
tandem
repeats
optimal
loading.
The
versatility
was
demonstrated
by
codisplaying
two
sequential
cascade
tunable
stoichiometry,
significantly
improving
conversion
maltodextrin
to
trehalose.
Furthermore,
we
integrated
Bxb1
recombinase-based
state
machine
(RSM)
genetic
circuit,
allowing
temporal
regulation
scaffold
expression
within
single
cell.
Finally,
system's
applicability
showcased
isomaltulose
production
from
low-cost
sucrose.
design
represents
advancement
surface-displayed
biocatalysis,
reactions
potential
applications
various
industrially
relevant
biocatalysts.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Cancer
poses
a
substantial
threat
and
serious
challenge
to
public
human
health,
driving
the
promotion
of
sophisticated
technologies
for
cancer
therapy.
While
conventional
chemotherapy
has
bottlenecks
such
as
low
delivery
efficiency,
strong
toxic
side
effects,
tumor
enrichment
barriers,
magnetic
micro/nanorobots
(MNRs)
emerge
promising
therapeutic
candidates
that
provide
alternative
strategies
MNR
is
kind
human-made
machine
micro-
or
nanosized,
reasonably
designed,
performs
command
tasks
through
self-actuated
externally
controlled
propulsion
mechanisms,
which
can
be
potentially
applied
in
theranostics.
Here,
this
review
first
introduces
components
constitute
typical
MNR,
including
body
part,
control
function
sensing
part.
Subsequently,
elucidates
representative
fabrication
methods
construct
MNRs
from
top-down
approaches
bottom-up
approaches,
covering
injection
molding,
self-rolling,
melt
electrospinning
writing,
deposition,
biotemplate
method,
lithography,
assembling,
3D
printing,
chemical
synthesis.
Furthermore,
focuses
on
multiple
applications
facing
diagnosis
treatment,
encompassing
imaging,
quantification,
drug
release,
synergy
with
therapies,
cell
manipulation,
surgical
assistance.
Then,
systematically
elaborates
biocompatibility
biosafety
MNRs.
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
This
intended
scientific
guidance
may
improve
comprehension
cognition
theranostics
platform
MNRs,
promoting
prospering
practical
application
development
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
Biohybrid
micro/nanorobots
hold
a
great
potential
for
advancing
biomedical
research.
These
tiny
structures,
designed
to
mimic
biological
organisms,
offer
promising
method
targeted
drug
delivery,
tissue
engineering,
biosensing/imaging,
and
cancer
therapy,
among
other
applications.
The
integration
of
biology
robotics
opens
new
possibilities
minimally
invasive
surgeries
personalized
healthcare
solutions.
key
challenges
in
the
development
biohybrid
include
ensuring
biocompatibility,
addressing
manufacturing
scalability,
enhancing
navigation
localization
capabilities,
maintaining
stability
dynamic
environments,
navigating
regulatory
hurdles,
successfully
translating
these
innovative
technologies
into
clinical
Herein,
recent
advancements,
challenges,
future
perspectives
related
applications
are
described.
Indeed,
this
review
sheds
light
on
cutting‐edge
developments
field,
providing
researchers
with
an
updated
overview
current
realm
applications,
offering
insights
their
practical
Furthermore,
it
delves
advancements
field
micro/nanorobotics,
comprehensive
analysis
state‐of‐the‐art
field.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4981 - 4981
Published: May 2, 2024
We
are
living
in
an
era
of
advanced
nanoscience
and
nanotechnology.
Numerous
nanomaterials,
culminating
nanorobots,
have
demonstrated
ingenious
applications
biomedicine,
including
breast
cancer
(BC)
nano-theranostics.
To
solve
the
complicated
problem
BC
heterogeneity,
non-targeted
drug
distribution,
invasive
diagnostics
or
surgery,
resistance
to
classic
onco-therapies
real-time
monitoring
tumors,
nanorobots
designed
perform
multiple
tasks
at
a
small
scale,
even
organelles
molecular
level.
Over
last
few
years,
most
been
bioengineered
as
biomimetic
biocompatible
nano(bio)structures,
resembling
different
organisms
cells,
such
urchin,
spider,
octopus,
fish,
spermatozoon,
flagellar
bacterium
helicoidal
cyanobacterium.
In
this
review,
readers
will
be
able
deepen
their
knowledge
structure,
behavior
role
several
types
among
other
theranostics.
summarized
here
characteristics
many
functionalized
nanodevices
counteract
main
neoplastic
hallmark
features
BC,
from
sustaining
proliferation
evading
anti-growth
signaling
resisting
programmed
cell
death
inducing
angiogenesis,
activating
invasion
metastasis,
preventing
genomic
instability,
avoiding
immune
destruction
deregulating
autophagy.
Most
these
function
targeted
self-propelled
smart
nano-carriers
nano-drug
delivery
systems
(nano-DDSs),
enhancing
efficiency
safety
chemo-,
radio-
photodynamic
therapy,
current
imagistic
techniques
used
diagnosis.
tested
vitro,
using
various
lines,
well
vivo,
mainly
based
on
mice
models.
still
waiting
for
that
low-cost,
wider
transition
favorable
effects
laboratory
clinical
practice.
