Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery DOI
Xinyi Zhang, Ling Li, Yuxin Ren

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.

Language: Английский

Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases DOI
Shuoxun Zhang, Huapan Fang,

Huayu Tian

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7015 - 7057

Published: Oct. 18, 2024

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing wide range of applications. Their unique advantages, such as rich source, good biocompatibility, excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, tissue engineering. However, conventional suffer from poor degradation

Language: Английский

Citations

6
Rational Design of NIR‐II Emitting Conjugated Polymer Derived Nanoparticles for Image‐Guided Cancer Interventions DOI
Nikita Gill, Indrajit Srivastava, Joshua Tropp

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Due to the reduced absorption, light scattering, and tissue autofluorescence in NIR-II (1000-1700 nm) region, significant efforts are underway explore diverse material platforms for vivo fluorescence imaging, particularly cancer diagnostics image-guided interventions. Of reported imaging agents, nanoparticles derived from conjugated polymers (CPNs) offer unique advantages alternative materials including biocompatibility, remarkable absorption cross-sections, exceptional photostability, tunable emission behavior independent of cell labeling functionalities. Herein, current state emitting CPNs summarized structure-function-property relationships highlighted that can be used elevate performance next-generation CPNs. Methods particle processing incorporating targeting modalities discussed, as well detailed characterization methods improve interlaboratory comparisons novel materials. Contemporary specifically apply therapies then highlighted. This review not only summarizes field, but offers future directions provides clarity over other classes agents.

Language: Английский

Citations

4
Dual-Mode Reactive Oxygen Species-Stimulated Carbon Monoxide Release for Synergistic Photodynamic and Gas Tumor Therapy DOI
Yuewen Yu, Le Zhang, Hanyu Jia

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31286 - 31299

Published: Oct. 30, 2024

Controllable carbon monoxide (CO) release simulated by light-generated reactive oxygen species (ROS) represents a promising approach for cancer therapy but is hampered low CO rate and ROS generation of conventional photosensitizers in hypoxia tumor microenvironments. In this study, we developed highly efficient nanoplatform (TPyNO

Language: Английский

Citations

4
A Novel Conjugated Polymer Synthesized via a Noble Metal-Free Catalyst in Photothermal Therapy of Hepatocellular Carcinoma Mediated by Second Near-Infrared (NIR-II) Laser DOI Creative Commons
Shengsheng Cui,

Xinni Pan,

Shanshan Fan

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101488 - 101488

Published: Jan. 13, 2025

Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by conversion efficiency material. In this study, we developed a novel ladder-type conjugated polymer, PPAPA, via phenazine ring fusion reaction. PPAPA exhibits high 75.2 % 1064 nm laser comparable benchmark organic agent SWCNT. Notably, synthesis avoids use noble metal catalysts, eliminating potential biotoxicity caused residual catalysts and ensuring optimal stability efficiency. Furthermore, demonstrates efficient near-infrared II (NIR-II) enabling deeper tissue penetration reduced absorption. This work comprehensively investigates properties evaluates its in tumor PTT, demonstrating as effective therapeutic strategy for treatment, offering new hope patients.

Language: Английский

Citations

0
Principles, progress, and prospects of photo-rechargeable zinc-ion batteries DOI

Kejun Jin,

Yingjian Yu

Journal of Energy Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Self-assembled hollow CuS@AuNRs/PDA nanohybrids with synergistically enhanced photothermal efficiency DOI

Chiyin Zhang,

Panping Yang,

Jingguo Li

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(34), P. 14315 - 14324

Published: Jan. 1, 2024

A NIR/pH dual-responsive hollow CuS@AuNRs/PDA nanocarrier with synergistically enhanced photothermal efficiency was prepared by electrostatic self-assembly method.

Language: Английский

Citations

1
Advances in polymer-centric nanomedicines for theranostic cancer treatment DOI

Anindita Bag,

Rahul Maheshwari

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106105 - 106105

Published: Aug. 28, 2024

Language: Английский

Citations

1
Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery DOI
Xinyi Zhang, Ling Li, Yuxin Ren

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.

Language: Английский

Citations

1