ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428
Published: Jan. 9, 2025
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(34), P. 44467 - 44484
Published: Aug. 14, 2024
Multiphase Pickering emulsions, including two or more active agents, are of great importance to effectively manage complicated wounds. However, current strategies based on emulsions still unsatisfying since they involve only stabilization by inactive particles and encapsulation the hydrophobic drugs in oil phase. Herein, thyme essential (TEO) was encapsulated shell functional tea polyphenol (TP)-curcumin (Cur) nanoparticles (TC NPs) exemplarily develop a novel emulsion (TEO/TC PE). Hydrophobic Cur loaded with hydrophilic TP obtain TC NPs, under homogenization, these NPs adsorbed surface TEO droplets form stable core-shell structure. Owing such an oil-in-water (O/W) structure, sequential release first from pH-responsive disintegrated then leaked yielded synergetic functions TEO/TC PE, leading enhanced antibacterial, biofilm elimination, antioxidant, anti-inflammatory activities. This injectable PE applied treat infected full-thickness skin defects, satisfactory wound healing effects were achieved rapid angiogenesis, collagen deposition, regeneration. The present constituted entirely plant-sourced products is biosafe expected spearhead future development dressings.
Language: Английский
Citations
5
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160726 - 160726
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125487 - 125487
Published: March 1, 2025
Language: Английский
Citations
0
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: March 29, 2025
As the clinical prevalence of antibiotic-resistant bacteria rises, effectiveness antibacterial drugs has been greatly reduced, hence, it is essential to create novel materials for combating bacterial infections. In recent years, antimicrobial peptides (AMPs) have demonstrated significant promise in addressing infections caused by bacteria, but as a natural product, they are limited terms activity and stability, cannot exert their full effect. The conjugation peptide-based biomaterials makes up this shortcoming, also improved, which lays foundation its application. This review aims introduce current progress AMPs-based treatment multidrug-resistant infections, covering topics from sources delivery combining biomaterial AMPs. addition, therapeutic advantages, including synergistic treatment, improved stability effectiveness, high biocompatibility, discussed. Finally, situation prospects AMP-based summarized.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142778 - 142778
Published: April 1, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
Hydrogels derived from self-assembling peptides provide considerable benefits in tissue engineering including their biocompatibility and extensive molecular diversity. Short are especially advantageous due to ease of production, ability self-assemble, repeatability. However, application is currently limited owing possible toxicity resulting the chemical modifications required for self-assembly coarse gelation conditions. Nucleobase-functionalized derivatives an opportunity use naturally obtained species minimize cytotoxicity. Therefore, nucleobase-functionalized hydrogels attracting significant interest varied architectures. Herein, we have synthesized a guanine-functionalized alanine derivative investigated formation coassembled hydrogel with guanosine. The development nucleic acid secondary structure within studied using circular dichroism wide-angle powder X-ray diffraction experiments. thermoreversible nature explored. evaluated by performing MTT assay. used cell growth, 2D cultures carried out on fibroblast McCoy epithelial A549 lines. Live-dead imaging performed staining fluorescein diacetate propidium iodide. proliferation over different time periods Alamar Blue Cytoskeletal both lines determine impact cells.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(52)
Published: Nov. 16, 2024
Abstract Staphylococcus aureus ( S. ), especially methicillin‐resistant (MRSA), causes wound infections, whose treatment remains a clinical challenge. Bacterium‐infected wounds often create acidic niches with pH 4.5–6.5. Endolysin LysSYL, which is derived from phage SYL, shows promise as an antistaphylococcal agent. However, endolysins generally exhibit instability and possess low bioavailability in microenvironments. Here, array of self‐assembling peptides designed, peptide L5 screened out based on its gel formation property bioavailability. exerted pH‐switchable antimicrobial effect (pH 5.5) formed biocompatible hydrogels at neutral 7.4). The LysSYL‐loaded can assemble L5@LysSYL hydrogels, increase thermal stability, the slow‐release LysSYL. Effective elimination achieved by through bacterial membrane disruption cell separation inhibition. Moreover, great potential promoting healing mouse model infected MRSA. Furthermore, are safe decrease cytokine levels number key factors for vessel formation, contribute to healing. Overall, effectively clean MRSA promote healing, suggests pH‐sensitive dressing management infections.
Language: Английский
Citations
3
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Wound care is a flourishing branch of healthcare wherein great amount research devoted to develop competent wound dressings. Safe, cost-effective, and biocompatible dressings aid in healing without inflicting external trauma subsequent scar formation. Toward this, we have attempted robust dressing material with self-healing antibacterial properties. We cross-linked chitosan 4-formyl phenylboronic acid (4-FPBA) situ generated dehydroascorbic (DHA) utilizing the dynamic imine boronate ester linkages. Displaying channeled microstructure SEM micrographs, hydrogel exhibits massive water uptake capacity ∼900% at acidic pH. The could completely self-heal within 3 min, results are further supported by rheological analysis. By virtue positive surface charge, it shows promising tissue adhesive property. Moreover, affords clean compliant removal from via dissolution induced dopamine potentially reduce secondary scarring peeling significantly act against skin infections caused
Language: Английский
Citations
2
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Citations
2