Synergizing Nanomaterials and Artificial Intelligence in Advanced Optical Biosensors for Precision Antimicrobial Resistance Diagnosis

ACS Synthetic Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 1600 - 1620

Published: June 6, 2024

Antimicrobial resistance (AMR) poses a critical global One Health concern, ensuing from unintentional and continuous exposure to antibiotics, as well challenges in accurate contagion diagnostics. Addressing AMR requires strategic approach that emphasizes early stage prevention through screening clinical, environmental, farming, livestock settings identify nonvulnerable antimicrobial agents the associated genes. Conventional diagnostics, like antibiotic susceptibility testing, possess drawbacks, including high costs, time-consuming processes, significant manpower requirements, underscoring need for intelligent, prompt, on-site diagnostic techniques. Nanoenabled artificial intelligence (AI)-supported smart optical biosensors present potential solution by facilitating rapid point-of-care detection with real-time, sensitive, portable capabilities. This Review comprehensively explores various types of nanobiosensors, such surface plasmon resonance sensors, whispering-gallery mode coherence tomography, interference reflection imaging surface-enhanced Raman spectroscopy, fluorescence microring tweezer biosensors, By harnessing unique advantages these nanoenabled revolutionary paradigm shift diagnostics can be achieved, characterized results, sensitivity, portability, integration Internet-of-Things (IoT) technologies. Moreover, enable personalized monitoring detection, significantly reducing turnaround time eliminating human resources needed sample preservation transportation. Their holistic environmental surveillance further enhances capabilities diverse settings, leading improved modern-age healthcare practices more effective management treatments. Embracing advanced tools promises bolster capacity combat safeguard Health.

Language: Английский

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Unlocking New Frontiers in Healthcare: The Impact of Nano-Optical Biosensors on Personalized Medical Diagnostics

Journal of Biotechnology, Journal Year: 2025, Volume and Issue: 400, P. 29 - 47

Published: Feb. 15, 2025

Language: Английский

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Engineered two-dimensional nanomaterials based diagnostics integrated with internet of medical things (IoMT) for COVID-19

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3774 - 3828

Published: Jan. 1, 2024

Engineered 2D nanomaterials-based smartphone-assisted detection approaches integrated with IoMT, focusing on reliable, sensitive, and rapid diagnostics for COVID-19.

Language: Английский

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Amyloid detection in neurodegenerative diseases using MOFs

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(19), P. 4553 - 4573

Published: Jan. 1, 2024

Neurodegenerative diseases (amyloid such as Alzheimer's and Parkinson's), stemming from protein misfolding aggregation, encompass a spectrum of disorders with severe systemic implications. Timely detection is pivotal in managing these owing to their significant impact on organ function high mortality rates. The diverse array amyloid disorders, spanning localized manifestations, underscores the complexity conditions highlights need for advanced methods. Traditional approaches have focused identifying biomarkers using imaging techniques (PET MRI) or invasive procedures. However, recent efforts use metal-organic frameworks (MOFs), versatile class materials known unique properties, revolutionizing disease detection. porosity, customizable structures, biocompatibility MOFs enable integration biomolecules, laying groundwork highly sensitive specific biosensors. These sensors been employed electrochemical photophysical that target species under neurodegenerative conditions. adaptability allows precise quantification proteins, offering potential advancements early diagnosis management. This review article delves into how contribute detecting by categorizing uses based different sensing methods, (EC), electrochemiluminescence (ECL), fluorescence, Förster resonance energy transfer (FRET), up-conversion luminescence (ULRET), photoelectrochemical (PEC) sensing. drawbacks MOF biosensors challenges encountered field are also briefly explored our perspective.

Language: Английский

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Recent advances in Electrochemical Biosensors for Bacterial Detection

Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100078 - 100078

Published: March 1, 2025

Language: Английский

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Advancements in nanosensors for detecting pathogens in healthcare environments

Environmental Science Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

ESKAPEE pathogens: where we can find them in hospital environments and how to detect through nanotechnologies devices.

Language: Английский

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NaYF₄:Yb/Ho upconversion nanoprobe incorporated gold nanoparticle (AuNP) based FRET immunosensor for the “turn-on” detection of cardiac troponin I

The Analyst, Journal Year: 2023, Volume and Issue: 149(1), P. 231 - 243

Published: Nov. 15, 2023

Cardiac troponin I (cTnI) is a significant biomarker for acute heart attack. Hence, fast, economical, easy and real time monitoring of cardiac great importance in diagnosis prognosis failure the healthcare domain. In this work, an immunoassay based on NaYF4:Yb/Ho photon-upconversion nanoparticle (UCNP) with narrow emission peaks at 540 nm 655 respectively, synthesized. Then, it encapsulated amino functionalized silica using 3-aminopropyltriethoxysilane (APTES) to form APTES@SiO2-NaYF4:Yb/Ho UCNPs. When AuNPs added system, fluorescence quenched by electrostatic interaction UCNPs, thereby exhibiting FRET-based biosensor. cTnI antigen introduced into developed probe, antibody-antigen complex formed surface UCNPs resulting recovery. The sensor shows linear response towards range from 0.1693 ng mL-1 1.9 low limit detection (LOD) 5.5 × 10-2 mL-1. probe exhibits adequate selectivity sensitivity when compared coexisting biomarkers, biomolecules human serum samples.

Language: Английский

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Rapid electrochemical detection of epinephrine in human serum based on polydopamine-wrapped cerium oxide nanocomposite

Hybrid Advances, Journal Year: 2023, Volume and Issue: 4, P. 100108 - 100108

Published: Nov. 16, 2023

Here, we report the development of a polydopamine (PDA) and CeO2 nanoparticle (NP) based electrochemical biosensor for investigation epinephrine (EP). PDA was decorated on NPs through simple mussel-inspired self-polymerization technique to produce PDA@CeO2 nanocomposite, which is later dispersed surface working electrode. The optical, structural, morphological, vibrational analysis nanocomposite determined via UV–vis, XRD, SEM, Raman techniques respectively. electrocatalytic performance PDA@CeO2/GCE examined by using various methods such as CV, DPV, EIS. fabricated PDA@CeO2-modified electrode shows good activity detect EP with high sensitivity specificity. efficacy enhanced its large specific area, electrical conductivity, active sites. Owing excellent characteristics, has lower detection limit 8.37 μM in wide linear range between 10 200 detection. performed exceptionally well terms selectivity, repeatability. spiked human serum samples yielded consistent results 20 100 14.79 μM. recovery % fall 97 105 indicates practical utility proposed real settings. Thus, highly effective potential be utilized variety applications due unique properties.

Language: Английский

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Detection of specific antibodies against SARS-CoV-2 spike protein via ultra-sensitive bio-functionalized carbonnitride-reduced graphene oxide electrochemical immunosensing platform in real samples

Materials Advances, Journal Year: 2023, Volume and Issue: 4(21), P. 5291 - 5304

Published: Jan. 1, 2023

Ultrasensitive immunosensing device based on bio-functionalized C 3 N 4 /RGO nanocomposite allows for exact differentiation between positive and negative real COVID-19 patient samples.

Language: Английский

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Optical point of care devices for diagnosis of urinary tract infections

Current Opinion in Biomedical Engineering, Journal Year: 2023, Volume and Issue: 28, P. 100513 - 100513

Published: Nov. 8, 2023

Urinary tract infections (UTIs) are common bacterial affecting any part of the urinary system. Accurate and rapid UTI diagnosis is crucial for initiating appropriate effective treatment preventing further complications. Traditional diagnostic methods based on culturing require specialized expertise, controlled environments urine specimens, specific analysis environments, these time-consuming. In contrast, optical devices offer tremendous advantages, including enhanced sensitivity, user-friendliness, portability. These can be integrated with conventional to enhance accessibility techniques, especially in resource-limited settings. Further research needed optimize devices' analytical performance cost-effectiveness harness their full potential diagnosis. This review delves into recent advancements optics-based pathogen detection. After providing a succinct overview UTIs existing clinical practices detection, diagnosis, treatment, most studies about technologies were reviewed, an exploration future prospects conclusive insights discussed. Unveiling technology promises revolutionize healthcare exemplifies inexhaustible possibilities at intersection science medicine.

Language: Английский

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