Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: March 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(7), P. 9126 - 9137
Published: Feb. 14, 2022
Hydrogels
that
combine
the
integrated
attributes
of
being
adhesive,
self-healable,
deformable,
and
conductive
show
great
promise
for
next-generation
soft
robotic/energy/electronic
applications.
Herein,
we
reported
a
dual-network
polyacrylamide
(PAAM)/poly(acrylic
acid)
(PAA)/graphene
(GR)/poly(3,4-ethylenedioxythiophene):poly(styrene
sulfonate)
(PEDOT:PSS)
(MAGP)
hydrogel
composed
dual-cross-linked
PAAM
PAA
as
well
PEDOT:PSS
GR
conducting
component
combines
these
features.
A
wearable
strain
sensor
is
fabricated
by
sandwiching
MAGP
hydrogels
between
two
dielectric
carbon
nanotubes
(CNTs)/poly(dimethylsiloxane)
(PDMS)
layers,
which
can
be
utilized
to
monitor
delicate
vigorous
human
motion.
In
addition,
hydrogel-based
act
deformable
triboelectric
nanogenerator
(D-TENG)
harvesting
mechanical
energy.
The
D-TENG
demonstrates
peak
output
voltage
current
141
V
0.8
μA,
respectively.
could
easily
light
52
yellow-light-emitting
diodes
(LEDs)
simultaneously
demonstrated
capability
power
small
electronics,
such
hygrometer
thermometer.
This
work
provides
potential
approach
development
energy
sources
self-powered
sensors.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(9), P. 3325 - 3350
Published: Jan. 1, 2023
This
review
provides
a
brief
overview
of
the
recent
developments
in
hydrogel
systems
that
respond
dynamically
to
various
stimuli,
including
some
interesting
fabrication
strategies,
and
their
application
cardiac,
bone,
neural
tissue
regeneration.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
20, P. 100614 - 100614
Published: March 22, 2023
Repairing
central
nervous
system
(CNS)
is
difficult
due
to
the
inability
of
neurons
recover
after
damage.
A
clinically
acceptable
treatment
promote
CNS
functional
recovery
and
regeneration
currently
unavailable.
According
recent
studies,
injectable
hydrogels
as
biodegradable
scaffolds
for
tissue
engineering
have
exceptionally
desirable
attributes.
Hydrogel
has
a
biomimetic
structure
similar
extracellular
matrix,
hence
been
considered
3D
scaffold
regeneration.
An
interesting
new
type
hydrogel,
hydrogels,
can
be
injected
into
target
areas
with
little
invasiveness
imitate
several
aspects
CNS.
Injectable
are
being
researched
therapeutic
agents
because
they
may
numerous
properties
tissues
reduce
subsequent
injury
regenerate
neural
tissue.
Because
their
less
adverse
effects
cost,
easier
use
implantation
pain,
faster
capacity,
more
than
non-injectable
hydrogels.
This
article
discusses
pathophysiology
kinds
brain
spinal
cord
engineering,
paying
particular
emphasis
experimental
studies.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(31), P. 21345 - 21364
Published: Jan. 1, 2023
Nanoparticle-modified
hydrogels
exhibit
substantial
promise
in
the
realm
of
wound
healing,
with
their
ability
to
expedite
tissue
regeneration,
mitigate
infection
risks,
and
facilitate
enhanced
therapeutic
outcomes.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 345 - 345
Published: Jan. 19, 2023
Tissue
engineering
(TE)
is
a
rapidly
expanding
field
aimed
at
restoring
or
replacing
damaged
tissues.
In
spite
of
significant
advancements,
the
implementation
TE
technologies
requires
development
novel,
highly
biocompatible
three-dimensional
tissue
structures.
this
regard,
use
peptide
self-assembly
an
effective
method
for
developing
various
structures
and
surface
functionalities.
Specifically,
arginine–glycine–aspartic
acid
(RGD)
family
peptides
known
to
be
most
prominent
ligand
extracellular
integrin
receptors.
Due
their
specific
expression
patterns
in
human
tissues
tight
association
with
pathophysiological
conditions,
RGD
are
suitable
targets
regeneration
treatment
as
well
organ
replacement.
Therefore,
RGD-based
ligands
have
been
widely
used
biomedical
research.
This
review
article
summarizes
progress
made
application
development.
Furthermore,
we
examine
effect
structure
sequence
on
efficacy
clinical
preclinical
studies.
Additionally,
outline
recent
advancement
functionalized
biomaterials
tissues,
including
corneal
repair,
artificial
neovascularization,
bone
TE.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(32)
Published: June 8, 2023
Abstract
The
desirable
implantable
neural
interfaces
can
accurately
record
bioelectrical
signals
from
neurons
and
regulate
activities
with
high
spatial/time
resolution,
facilitating
the
understanding
of
neuronal
functions
dynamics.
However,
electrochemical
performance
(impedance,
charge
storage/injection
capacity)
is
limited
miniaturization
integration
electrodes.
“crosstalk”
caused
by
uneven
distribution
elctric
field
leads
to
lower
electrical
stimulation/recording
efficiency.
mismatch
between
stiff
electrodes
soft
tissues
exacerbates
inflammatory
responses,
thus
weakening
transmission
signals.
Though
remarkable
breakthroughs
have
been
made
through
incorporation
optimizing
electrode
design
functionalized
nanomaterials,
chronic
stability,
long‐term
activity
in
vivo
still
need
further
development.
In
this
review,
interface
challenges
mainly
on
electrochemistry
biology
are
discussed,
followed
summarizing
typical
optimization
technologies
exploring
recent
advances
application
based
traditional
metallic
materials,
emerging
2D
conducting
polymer
hydrogels,
etc.,
for
enhancing
interfaces.
strategies
improving
durability
including
enhanced
adhesion
minimized
response,
also
summarized.
promising
directions
finally
presented
provide
enlightenment
high‐performance
future,
which
will
promote
profound
progress
neuroscience
research.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 23, 2024
Abstract
The
three-dimensional
(3D)
cell
culture
system
is
being
employed
more
frequently
to
investigate
engineering
and
tissue
repair
due
its
close
mimicry
of
in
vivo
microenvironments.
In
this
study,
we
developed
natural
biomaterials,
including
hyaluronic
acid,
alginate,
gelatin,
mimic
the
creation
a
3D
human
mesenchymal
stem
(hMSC)
extracellular
environment
selected
hydrogels
with
high
proliferation
capacity
for
MSC
culture.
Human
cells
were
encapsulated
within
hydrogels,
an
investigation
was
conducted
into
effects
on
viability
proliferation,
stemness
properties,
telomere
activity
compared
2D
monolayer
Hydrogel
characterization,
Live/Dead
assay,
gene
expression,
relative
length,
stemness-related
proteins
by
immunofluorescence
staining
examined.
results
showed
that
alginate-hyaluronic
acid
(AL-HA)
increased
grown
as
cellular
spheroids
presented
survival
rate
77.36%
during
period
14
days.
Furthermore,
expression
genes
(
OCT-4
,
NANOG
SOX2
SIRT1
),
growth
development
YAP
TAZ
Ki67
)
after
Moreover,
MSCs
enhanced,
indicated
upregulation
telomerase
reverse
transcriptase
hTERT
length
(T/S
ratio)
Altogether,
these
data
suggest
could
serve
promising
material
maintaining
properties
might
be
suitable
carrier
proposals.
Polymers,
Journal Year:
2025,
Volume and Issue:
17(4), P. 542 - 542
Published: Feb. 19, 2025
Flexible
sensors
are
revolutionizing
wearable
and
implantable
devices,
with
conductive
hydrogels
emerging
as
key
materials
due
to
their
biomimetic
structure,
biocompatibility,
tunable
transparency,
stimuli-responsive
electrical
properties.
However,
fragility
limited
durability
pose
significant
challenges
for
broader
applications.
Drawing
inspiration
from
the
self-healing
capabilities
of
natural
organisms
like
mussels,
researchers
embedding
self-repair
mechanisms
into
improve
reliability
lifespan.
This
review
highlights
recent
advances
in
(SH)
hydrogels,
focusing
on
synthesis
methods,
healing
mechanisms,
strategies
enhance
multifunctionality.
It
also
explores
wide-ranging
applications,
including
vivo
signal
monitoring,
biochemical
sensors,
supercapacitors,
flexible
displays,
triboelectric
nanogenerators,
bioelectronics.
While
progress
has
been
made,
remain
balancing
efficiency,
mechanical
strength,
sensing
performance.
offers
insights
overcoming
these
obstacles
discusses
future
research
directions
advancing
SH
hydrogel-based
bioelectronics,
aiming
pave
way
durable,
high-performance
devices
next-generation
technologies.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(39)
Published: March 21, 2023
Short
designer
self-assembling
peptide
(dSAP)
biomaterials
are
a
new
addition
to
the
hemostat
group.
It
may
provide
diverse
and
robust
toolbox
for
surgeons
integrate
wound
microenvironment
with
much
safer
stronger
hemostatic
capacity
than
conventional
materials
agents.
Especially
in
noncompressible
torso
hemorrhage
(NCTH),
diffuse
mucosal
surface
bleeding,
internal
medical
bleeding
(IMB),
respect
optimal
formulation,
dSAP
ingenious
nanofiber
alternatives
make
bioactive
neural
scaffold,
nasal
packing,
large
coverage
gastrointestinal
surgery
(esophagus,
gastric
lesion,
duodenum,
lower
digestive
tract),
epicardiac
cell-delivery
carrier,
transparent
matrix
barrier,
so
on.
Herein,
multiple
surgical
specialties,
dSAP-biomaterial-based
nano-hemostats
achieve
safe,
effective,
immediate
hemostasis,
facile
healing,
potentially
reduce
risks
delayed
rebleeding,
post-operative
or
related
complications.
The
biosafety
vivo,
indications,
tissue-sealing
quality,
feasibility,
local
usability
addressed
comprehensively
sequentially
pursued
develop
useful
techniques
better
performance.
Here,
state
of
art
all-round
advancements
nano-hemostatic
approaches
provided.
Relevant
critical
insights
will
inspire
exciting
investigations
on
nanotechnology,
next-generation
biomaterials,
promising
prospects
clinics.
