International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125315 - 125315
Published: Feb. 1, 2025
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131335 - 131335
Published: April 10, 2024
Language: Английский
Citations
47
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: Feb. 6, 2024
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.
Language: Английский
Citations
38
RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564
Published: Jan. 1, 2024
Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.
Language: Английский
Citations
38
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 300 - 300
Published: Feb. 21, 2024
Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.
Language: Английский
Citations
24
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105689 - 105689
Published: April 21, 2024
In the last few years, wound healing and development of "ideal" biomaterials that provide quick recovery minimize scarring have represented one most important priorities researchers. this direction, silk fibroin (SF) scaffolds gained substantial awareness, as a promising polymer owing to their increased biocompatibility, outstanding mechanical properties, biodegradability, especially tensile strength. Furthermore, SF is acknowledged accelerate process by encouraging cell growth proliferation, also migration different types cells are included in stages process. Therefore, metal oxide nanoparticles (NPs), such iron (FeO), copper (CuO), zinc (ZnO), or magnesium (MgO) NPs, been extensively researched for antimicrobial properties ability enhance tissue regeneration addition SF. When introduced within scaffolds, these NPs impart enhanced including improved scaffold stability durability. Moreover, presence could increase biocompatibility facilitating adhesion, migration, ultimately promoting processes. The incorporation other natural polymers into has thus emerged favorable method therapeutic potential developed biomaterial. This review aims an overview advancements containing applications.
Language: Английский
Citations
14
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 155 - 155
Published: Jan. 23, 2024
Wound infection due to bacterial invasion at the wound site is one of primary challenges associated with delayed healing. Microorganisms tend form biofilms that protect them from harm, leading their multidrug resistance. The alarming increase in antibiotic resistance poses a threat Hence, urgent need for novel dressing materials capable managing crucial expediting recovery. There considerable interest polymeric dressings embedded bioactive substances, such as metal-based nanoparticles, potential solutions treating microbially infected wounds. Metal-based nanoparticles have been widely used management wounds broad antimicrobial efficacy. This review focuses on polymer-based and loaded like silver, gold, magnesium oxide, or zinc oxide. When compared, oxide-loaded exhibited higher antibacterial activity against Gram-positive strains silver nanoparticle-loaded gram-negative strains. However, infused both displayed synergistic effect bacteria. Furthermore, these antibiofilm generation reactive oxygen species while accelerating closure vitro vivo.
Language: Английский
Citations
13
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130835 - 130835
Published: March 15, 2024
Language: Английский
Citations
9
Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)
Published: Aug. 28, 2024
Nanocomposite hydrogels (NHs) have emerged as a groundbreaking tool in biomedical applications, offering remarkable versatility and efficacy. Integrating wide range of nanoparticles, including carbon-based, polymeric, ceramic, metallic nanomaterials, within hydrogel networks results nanocomposites with superior properties tailored functionalities. Recent research has highlighted their potential to address key challenges drug delivery, cancer therapy, tissue regeneration, biosensing, wound healing, outstanding biocompatibility bioavailability. Nanohydrogels demonstrate significant promise delivery systems biological sensors, providing sustained therapeutic activity at targeted sites. This reduces the frequency administration minimizes harmful side effects. In healthcare sector, they applications ranging from therapy aesthetic corrections are leading topic regeneration research. comprehensive review Biomedical Applications investigates latest advancements NHs, focusing on classification, unique properties, diverse applications. By identifying future prospects existing gaps, this aims highlight diagnostic nanocomposite technology, covering way for further advancement field.
Language: Английский
Citations
9
DARU Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 32(1), P. 379 - 419
Published: Jan. 15, 2024
Language: Английский
Citations
8
Surgeries, Journal Year: 2024, Volume and Issue: 5(3), P. 640 - 659
Published: Aug. 9, 2024
The skin is crucial for homeostasis and body defense, requiring quick healing to maintain internal balance. Initially used bone repair, calcium hydroxyapatite (HAp) now being studied soft tissue engineering. This literature review investigated HAp’s role in repair through searches on PubMed, Scopus (Elsevier), Science Direct, Springer Link, Google Scholar databases without time restrictions, using keywords “hydroxyapatite AND wound” repair”. Inclusion criteria encompassed vivo studies humans animals, English publications, full access, sufficient data repair. Exclusions included duplicates, unrelated articles, editor letters, reviews, comments, conference abstracts, dissertations, theses. Out of the 472 articles initially identified, 139 met inclusion criteria, with 21 focusing HAp Findings indicate that nano-HAp regeneration are promising, especially when combined other biomaterials, offering antimicrobial anti-inflammatory benefits stimulating angiogenesis. suggests their potential application dermatology, surgery, dentistry, extending versatility from hard tissues enhancing critical properties accelerating healing.
Language: Английский
Citations
8