International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 4677 - 4703
Published: April 1, 2025
Despite
relentless
effort
to
study
glioma
treatment,
the
prognosis
for
patients
remains
poor.
The
main
obstacles
include
high
rate
of
recurrence
and
difficulty
passing
blood-brain
barrier
(BBB)
therapeutic
drugs.
Nanomaterials
owing
their
special
physicochemical
properties
have
been
used
in
a
wide
range
fields
thus
far.
nanodrug
delivery
system
(NDDS)
with
ability
crossing
BBB,
targeting
site,
maintaining
drug
stability
controlling
release,
has
significantly
enhanced
anti-tumor
effect,
improving
patients.
Aligned
nanofibers
(NFs)
are
ideal
materials
establish
vitro
models
microenvironment
(GME),
enabling
exploration
mechanism
cell
migration
invasion
discover
novel
targets.
Moreover,
NFs
now
widely
applications
such
as
radiotherapy,
phototherapy,
thermotherapy
immunotherapy.
absolute
dominance
anti-glioma
applications,
there
still
some
problems
further
optimization
NDDS,
impact
interactions
between
protein
corona
(PC)
on
therapy.
This
paper
will
shed
light
latest
systems
mimicking
tumor
(TME),
discuss
how
optimize
NDDS
eliminate
or
utilize
nanomedicine-PC
interactions.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117180 - 117180
Published: July 27, 2024
Sepsis
and
septic
shock
are
critical
medical
conditions
characterized
by
a
systemic
inflammatory
response
to
infection,
significantly
contributing
global
mortality
rates.
The
progression
multiple
organ
dysfunction
syndrome
(MODS)
represents
the
most
severe
complication
of
sepsis
markedly
increases
clinical
mortality.
Central
pathophysiology
sepsis,
endothelial
cells
play
crucial
role
in
regulating
microcirculation
maintaining
barrier
integrity
across
various
organs
tissues.
Recent
studies
have
underscored
pivotal
function
development
sepsis-induced
MODS.
This
review
aims
provide
comprehensive
overview
MODS,
with
specific
focus
on
dysfunction.
It
also
compiles
compelling
evidence
regarding
potential
small
molecules
that
could
attenuate
subsequent
multi-organ
damage
modulating
function.
Thus,
this
serves
as
an
essential
resource
for
practitioners
involved
diagnosing,
managing,
providing
intensive
care
associated
injuries,
emphasizing
importance
targeting
enhance
outcomes
patients.
Journal of Virology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
ABSTRACT
Pseudorabies
virus
(PRV)
is
a
porcine
neurotropic
alphaherpesvirus
that
infects
peripheral
tissues
of
its
host,
spreads
into
the
nervous
system,
and
establishes
life-long
latency
in
neuronal
cells.
During
productive
infection,
PRV
replicates
rapidly
causes
pseudorabies
or
Aujeszky’s
disease.
Reactivation
from
latent
infection
system
may
lead
to
anterograde
axonal
transport
progeny
virions,
leading
recurrent
epithelial
layer
spread.
Dexamethasone
(DEX),
member
glucocorticoid
family
widely
used
clinical
treatment
as
high-efficiency
receptor
(GR)
agonist,
known
trigger
reactivation
alphaherpesviruses
like
closely
related
bovine
1.
In
current
study,
two
cell
type-dependent
distinct
regulatory
mechanisms
during
are
described.
neuron-like
cells,
DEX
upregulates
expression
IE180
promotes
viral
infection.
addition,
we
found
GR
activates
promoter
by
binding
multiple
response
elements.
The
amino
acids
A465,
P631,
I634
were
be
critical
for
activation.
impact
on
cells
was
also
investigated.
Interestingly,
downregulate
suppress
Mechanistically,
activation
VP16/Oct-1
(octamer-binding
transcription
factor
1)
complex
suppressed
DEX-mediated
degradation
Oct-1
summary,
our
work
reveals
distinct,
biological
functions
respectively.
IMPORTANCE
can
infect
mucosal
epithelium
resulting
acute
this
describe
replication
while
it
suppresses
through
regulations
transactivator
IE180,
thereby
revealing
mechanism
Therefore,
findings
provide
new
perspective
role
glucocorticoids
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Liposomes
are
highly
beneficial
nanocarrier
systems
due
to
their
biocompatibility,
low
toxicity,
and
exceptional
inclusiveness,
which
lead
improved
drug
bioavailability.
For
biological
applications,
accurate
control
over
these
nanoparticles'
mean
size
distribution
is
essential.
Micromixers
facilitate
the
continuous
production
of
liposomes,
enhancing
precision
regulation
reproducibility.
In
this
research,
performance
a
stainless
steel
316L
micromixer
was
evaluated
by
using
COMSOL
Multiphysics
simulations.
The
liposomes
were
precisely
optimized
design
experiments
techniques
in
microfluidic
setup,
then
dexamethasone
sodium
phosphate
(DSP)
successfully
encapsulated
liposome
nanoparticles.
physicochemical
characteristics
such
as
ζ-potential,
size,
DSP
loading
capacity,
encapsulation
efficiency,
release,
assessed.
Transmission
electron
microscopy
dynamic
light
scattering
analysis
used
examine
structures
liposomes.
release
kinetics
study
conducted
analyze
delivery
system,
Higuchi
equation
determined
be
most
suitable
equation.
chip
shown
capable
creating
small-sized
with
small
130
nm,
exhibiting
monodispersed
polydispersity
populations.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(22), P. 13725 - 13725
Published: Nov. 8, 2022
The
complementary
interaction
of
microRNAs
(miRNAs)
with
their
binding
sites
in
the
3'untranslated
regions
(3'UTRs)
target
gene
mRNAs
represses
translation,
playing
a
leading
role
expression
control.
MiRNA
recognition
elements
(MREs)
3'UTRs
genes
often
contain
single
nucleotide
polymorphisms
(SNPs),
which
can
change
affinity
for
miRNAs
to
dysregulated
expression.
Accumulated
data
suggest
that
these
SNPs
be
associated
various
human
pathologies
(cancer,
diabetes,
neuropsychiatric
disorders,
and
cardiovascular
diseases)
by
disturbing
MREs
located
mRNA
3'UTRs.
Numerous
show
3'UTR
individual
drug
susceptibility
resistance
mechanisms.
In
this
review,
we
brief
on
such
focusing
most
rigorously
proven
cases.
Some
belong
conventional
from
drug-metabolizing
system
(in
particular,
coding
cytochromes
P450
(CYP
450),
phase
II
enzymes
(SULT1A1
UGT1A),
ABCB3
transporter
regulators
(PXR
GATA4)).
Other
examples
are
related
involved
DNA
repair,
RNA
editing,
specific
metabolisms.
We
discuss
gene-by-gene
studies
genome-wide
approaches
utilized
or
potentially
utilizable
detect
MRE
response
drugs.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 12, 2023
Abstract
Background
A
significant
proportion
of
septic
patients
with
acute
lung
injury
(ALI)
are
recognized
late
due
to
the
absence
an
efficient
diagnostic
test,
leading
postponed
treatments
and
consequently
higher
mortality.
Identifying
biomarkers
may
improve
screening
identify
at
high
risk
ALI
earlier
provide
potential
effective
therapeutic
drugs.
Machine
learning
represents
a
powerful
approach
for
making
sense
complex
gene
expression
data
find
robust
biomarkers.
Methods
The
datasets
were
obtained
from
GEO
ArrayExpress
databases.
Following
quality
control
normalization,
(GSE66890,
GSE10474
GSE32707)
merged
as
training
set,
four
machine
feature
selection
methods
(Elastic
net,
SVM,
random
forest
XGBoost)
applied
construct
model.
other
considered
validation
sets.
To
further
evaluate
performance
predictive
value
model,
nomogram,
Decision
Curve
Analysis
(DCA)
Clinical
Impact
(CIC)
constructed.
Finally,
small
molecular
compounds
interacting
selected
features
explored
CTD
database.
Results
results
GSEA
showed
that
immune
response
metabolism
might
play
important
role
in
pathogenesis
sepsis-induced
ALI.
Then,
52
genes
identified
putative
by
consensus
all
methods.
Among
them,
5
(ARHGDIB,
ALDH1A1,
TACR3,
TREM1
PI3)
used
predict
diagnosis
accuracy.
external
(E-MTAB-5273
E-MTAB-5274)
demonstrated
model
had
great
accuracy
AUC
0.725
0.833,
respectively.
In
addition,
DCA
CIC
value.
(Curcumin,
Tretinoin,
Acetaminophen,
Estradiol
Dexamethasone)
screened
agents
Conclusion
This
multiple
algorithms
able
distinguish
patients.
could
ALI,
targets
