Alginate-Based hydrogels with inorganic Nanomaterials: A promising approach for wound healing and bone tissue regeneration

European Polymer Journal, Journal Year: 2024, Volume and Issue: 212, P. 113057 - 113057

Published: April 23, 2024

Language: Английский

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Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 1, 2025

Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse at late stage, significantly impairing joint function. While MRI highly effective tool for diagnosing ONFH its early stages, challenges remain due to limited availability high cost MRI, as well absence routine screening asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying drugs are still under investigation/development. Considering that supply plays key role pathology ONFH, angiogenic therapies have been put forward promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold potential treatment. this review, we introduce advances research into summarize novel angiogenesis. review sheds light upon new directions future ONFH.

Language: Английский

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Magnesium-containing bioceramics stimulate exosomal miR-196a-5p secretion to promote senescent osteogenesis through targeting Hoxa7/MAPK signaling axis

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 14 - 29

Published: Nov. 4, 2023

Stem cell senescence is characterized by progressive functional dysfunction and secretory phenotypic changes including decreased proliferation, of osteogenic angiogenic differentiation, increased secretion the senescence-associated phenotype (SASP), which bring difficulties for bone repair. Rescuing or delaying aged marrow mesenchymal stem cells (O-BMSCs) was considered as effective strategy regeneration in aging microenvironment. Magnesium (Mg) ion released from bioceramics reported to facilitate via enhancing osteogenesis alleviating senescence. In this study, Akermanite biocreamics (Akt) containing Mg a model demonstrated promote angiogenesis effects O-BMSCs activating MAPK signaling pathway vitro. Moreover, enhanced might be attributed Mg-containing Akt-mediated exosomal miR-196a-5p cargo targeting Hoxa7 activation pathway. Furthermore, vivo study confirmed that 3D-printed porous Akt scaffolds effectively cranial defects rats. The current results indicated exosomal-miR-196a-5p/Hoxa7/MAPK axis potential mechanism underlying osteogenesis. exosome-meditaed therapy stimulated contained other biomaterials serve candidate repair individuals.

Language: Английский

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Double-layer calcium phosphate sandwiched siloxane composite coating to enhance corrosion resistance and biocompatibility of magnesium alloys for bone tissue engineering

Progress in Organic Coatings, Journal Year: 2023, Volume and Issue: 177, P. 107417 - 107417

Published: Jan. 28, 2023

Language: Английский

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Investigating the anti-inflammatory and bone repair-promoting effects of an injectable porous hydrogel containing magnesium ions in a rat periodontitis mode

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 207 - 220

Published: Jan. 6, 2024

Periodontitis is associated with several systemic diseases, and advanced periodontitis often linked to an extensive inflammatory microenvironment irregularly shaped alveolar bone defects. However, eliminating periodontal inflammation in a minimally invasive manner while repairing defects clinically challenging. In comparison traditional grafts, thermo-sensitive hydrogel can be injected into deep pockets, forming filling the situ. this study, porous injectable hydrogels containing magnesium ions were prepared by adding particles (MPs) glycerophosphate solution combining mixture chitosan solution. The incorporation of MPs created interconnected pores hydrogel, exhibiting high cytocompatibility maintaining cell viability, proliferation, spreading, osteogenesis vitro. Evaluation on experimental rat model, using micro-computed tomography histological analyses, demonstrated that Mg2+-containing effectively reduced inflammation, inhibited osteoclast activity, partially repaired inflammation-induced loss. These results suggest might promising candidates for treating periodontitis.

Language: Английский

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Marine biomaterials for sustainable bone regeneration

Giant, Journal Year: 2024, Volume and Issue: 19, P. 100298 - 100298

Published: June 3, 2024

The field of bone regeneration has witnessed significant advancements with the exploration and incorporation marine biomaterials, offering promising avenues for orthopaedic dental applications. Marine environments are a rich source biological materials unique properties conducive to healing regeneration. Repurposing reusing some waste by-products products not only contribute environmental protection but also drives development economy, thereby achieving sustainable development. Moreover, lower production costs associated abundant availability easy processing biomaterials make therapies more accessible broader population, enhancing global health equity. By exploring current research progressions on recounting their sources, properties, mechanisms action, applications in research, this review provides comprehensive overview potential challenges future

Language: Английский

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Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Advanced NanoBiomed Research, Journal Year: 2023, Volume and Issue: 3(9)

Published: Aug. 3, 2023

Diverse applications of nanoparticles (NP) have been revolutionary for various industrial sectors worldwide. In particular, magnetic (MNP) gained great interest because their in specialized medical areas. This review starts with a brief overview the behavior MNP and short description most used synthesis methods. The second part is dedicated to tissue engineering, emphasizing calcium phosphate‐based NP intrinsic properties, recently highlighted literature as alternative viable solutions bone regeneration. challenges associated controversial long‐term toxicity effects can be overcome using this new generation multifunctional bone‐like materials. Furthermore, influence field parameters, such modality application, intensity, spatial distribution, on biological materials, especially repair, shown. last presents current state art regarding development biomaterials additive manufacturing (AM), aiming fabricate scaffolds by AM technologies, focusing engineering applications.

Language: Английский

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Magnesium/gallic acid bioMOFs laden carbonized mushroom aerogel effectively heals biofilm-infected skin wounds

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122347 - 122347

Published: Oct. 4, 2023

Language: Английский

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Thermally and mechanically tuned interfaces of magnesium alloys for bioimplant applications

Surfaces and Interfaces, Journal Year: 2023, Volume and Issue: 41, P. 103284 - 103284

Published: Aug. 18, 2023

Language: Английский

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Different Modification Methods of Poly Methyl Methacrylate (PMMA) Bone Cement for Orthopedic Surgery Applications.

PubMed, Journal Year: 2023, Volume and Issue: 11(8), P. 485 - 492

Published: Jan. 1, 2023

In clinical practice, bone defects that occur alongside tumors, infections, or other diseases present significant challenges in the orthopedic field. Although autologous and allogeneic grafts are introduced as common traditional remedies this field, their applications have a series of limitations. Various approaches been attempted to treat large irregularly shaped defects; however, success has less than optimal due range issues related material design. However, recent years, additive manufacturing emerged promising solution challenge creating implants can be perfectly tailored fit individual during surgical procedures. By fabrication constructs with specific designs using technique, surgeons able achieve much better outcomes for patients. Polymers, ceramics, metals used biomaterials Orthopedic Surgery fields. Polymeric scaffolds successfully total joint replacements, soft tissue reconstruction, fusion, fracture fixation devices. The use polymeric biomaterials, either form pre-made solid injectable pastes harden situ, shows great promise substitute commonly autografts allografts. Polymethyl methacrylate (PMMA) is one most widely polymer cement surgery. paper begins an introduction will then provide overview properties, advantages/disadvantages, applications, modifications PMMA cement.

Language: Английский

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