The Impact of Nano-Hydroxyapatite Scaffold Enrichment on Bone Regeneration In Vivo—A Systematic Review

Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 386 - 386

Published: June 25, 2024

In order to ensure improved and accelerated bone regeneration, nano-hydroxyapatite scaffolds are often enriched with different bioactive components further accelerate improve healing. this review, we critically examined whether the enrichment of nHAp/polymer growth factors, hormones, polypeptides, microRNAs exosomes new formation in vivo.

Language: Английский

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Integrating Micro- and Nanostructured Platforms and Biological Drugs to Enhance Biomaterial-Based Bone Regeneration Strategies

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 140 - 162

Published: Dec. 2, 2024

Bone defects resulting from congenital anomalies and trauma pose significant clinical challenges for orthopedics surgeries, where bone tissue engineering (BTE) aims to address these by repairing that fail heal spontaneously. Despite numerous advances, BTE still faces several challenges, i.e., difficulties in detecting tracking implanted cells, high costs, regulatory approval hurdles. Biomaterials promise revolutionize grafting procedures, heralding a new era of regenerative medicine advancing patient outcomes worldwide. Specifically, novel bioactive biomaterials have been developed promote cell adhesion, proliferation, differentiation osteoconductive osteoinductive characteristics, stimulating regeneration repair, particularly complex skeletal caused trauma, degeneration, neoplasia. A wide array biological therapeutics emerged, drawing the diverse spectrum gene therapy, immune interactions, RNA molecules. This review will provide insights into current state potential future strategies regeneration.

Language: Английский

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Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration

Macromol—A Journal of Macromolecular Research, Journal Year: 2024, Volume and Issue: 4(2), P. 165 - 189

Published: April 1, 2024

MiRNA-based therapies represent an innovative and promising strategy applicable to various medical fields, such as tissue regeneration the treatment of numerous diseases, including cancer, cardiovascular problems, viral infections. MiRNAs, a group small non-coding RNAs, play critical role in regulating gene expression at post-transcriptional level modulate several signaling pathways that maintain cellular homeostasis. The clinical trials discussed review herald new therapeutic era for miRNAs, particularly engineering, using synthetic exogenous mimic miRNAs antisense (anti-miRNAs) restore health. This provides overview miRNAs’ biogenesis, mechanism action, regulation, potential applications, followed by examination challenges associated with transport delivery miRNAs. possibility non-viral vectors protect against degradation ensure effective miRNA is highlighted, focusing on advantages emerging use 3D biomaterial scaffolds anti-miRNAs facilitate repair regeneration. Finally, assesses current landscape miRNA-activated scaffold preclinical studies bone, cartilage, skin tissues, emphasizing their emergence frontier personalized medicine.

Language: Английский

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Exploring Circulating MiRNA Signature for Osteosarcoma Detection; Bioinformatics-Based Analyzing and Validation

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155615 - 155615

Published: Oct. 1, 2024

Language: Английский

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