Published: Jan. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 18, 2025
Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.
Language: Английский
Citations
21
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1582 - 1582
Published: Jan. 27, 2024
Preferentially Expressed Antigen in Melanoma (PRAME), a member of the cancer/testis antigen family, is central to field skin cancer diagnostics and therapeutics. As nuclear receptor transcriptional regulator, PRAME plays critical role inhibiting retinoic acid signalling, which essential for cell differentiation proliferation. Its aberrant overexpression various malignancies, particularly cutaneous melanoma, associated with more aggressive tumour phenotypes, positioning as both diagnostic prognostic marker. In typically highly expressed, contrast its weak or absent expression benign nevi, thereby improving accuracy differential diagnoses. The value extends lesions. It significantly expressed uveal correlating an increased risk metastasis. acral melanomas, especially those histopathological ambiguity, helps improve accuracy. However, spitzoid ungual melanocytic lesions inconsistent requires comprehensive approach accurate assessment. soft tissue sarcomas, may be helpful differentiating melanoma from clear sarcoma, important distinction due their similar histological appearance but different treatment approaches prognosis, detecting dedifferentiated undifferentiated melanomas. non-melanoma cancers such basal carcinoma, squamous Merkel variable can lead complexity. Despite these challenges, potential therapeutic target significant. Emerging immunotherapies, including T-cell-based therapies vaccines targeting PRAME, are being investigated exploit cancer-specific expression. Ongoing research into molecular mechanism action continues open new avenues therapeutics, transform management related cancers.
Language: Английский
Citations
18
Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122694 - 122694
Published: June 28, 2024
Language: Английский
Citations
10
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 203 - 214
Published: July 23, 2024
Language: Английский
Citations
9
MedComm, Journal Year: 2024, Volume and Issue: 5(3)
Published: March 1, 2024
Abstract Cancer is a major cause of death globally, and traditional treatments often have limited efficacy adverse effects. Immunotherapy has shown promise in various malignancies but less effective tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) been associated favorable response to immunotherapy improved survival cancer patients. However, the immunological mechanisms clinical significance TLS malignant are not fully understood. In this review, we elucidate composition, neogenesis, immune characteristics tumors, as well inflammatory development. An in‐depth discussion unique TLSs lung cancer, breast melanoma, soft tissue sarcomas will be presented. Additionally, therapeutic implications TLS, including its role marker prognosis, strategies promote formation maturation explored. Overall, aim provide comprehensive understanding tumor microenvironment suggest potential interventions for treatment.
Language: Английский
Citations
5
IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 8
Published: Feb. 24, 2024
Cancer vaccines based on tumor cell components have shown promising results in animal and clinical studies. The vaccine system contains abundant antigen components, which can activate the immune by antigens. However, their efficacy has been limited inability of antigens delivery, are core vaccines, further fail to be presented activation effective cells. Nanotechnology offers a novel platform enhance immunogenicity tumor-associated deliver them antigen-presenting cells (APCs) more efficiently. In addition, nanotreatment derivate active ingredients could also help improve effectiveness cancer vaccines. this review, we summarize recent advances development combination nanotechnology tumor-based ingredients, including liposomes, polymeric nanoparticles, metallic virus-like particles membrane, lysate, specific These nanovaccines designed increase uptake, prolong presentation, modulate responses through codelivery immunostimulatory agents. We discuss challenges opportunities translation these nanovaccines.
Language: Английский
Citations
4
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1047 - 1063
Published: Jan. 1, 2025
Colorectal cancer (CRC) is a highly malignant and aggressive gastrointestinal tumor. Due to its weak immunogenicity limited immune, cell infiltration lead ineffective clinical outcomes. Therefore, improve the current prophylaxis treatment scheme, offering favorable strategy efficient against CRC urgently needed. Here, we developed nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. The characterized transmission electron microscopy Zetasizer. It evaluated vitro, where NVs facilitated endocytosis maturation of DCs, vivo, improved efficacy therapy. In addition, further confirmed mechanisms how TLR4 MGL synergistic pathway endow nanovaccines towards dendritic cells (DCs). Finally, safety tumor immunosuppressive microenvironment were tumor-bearing mouse model. We successfully that facilitates DCs via involving MGL, (DCs) promote differentiation, thereby enhancing cytotoxicity CD8+T cells. Consequently, LBP-CD155L can potentiate prophylactic therapeutic administration model, as evidenced decreased myeloid-derived suppressor (MDSCs) Tregs, reprogrammed macrophage phenotypes, promoted polarization from M2-like macrophages M1-like macrophages, increased effector T Prophylactic combination regimens anti-PD-1 demonstrate synergism stimulates T-cell into tumors counteracts immunosuppression, leading remarkable remission immune checkpoint therapy solid tumors. Our work provided may serve promising tool for reversing ICB CRC.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Abstract Lung cancer remains one of the deadliest cancers globally, which may be attributed in part to a limited understanding its development. Therefore, exploration fundamental processes lung and innovative therapies is imminent. Recently, immunotherapy has become crucial topic interest, it pertains metabolism tumor microenvironment. In particular, glutamine plays pivotal role immunotherapy. This review summarizes crosstalk between immune microenvironment, explores potential strategies as an enhancement It also discusses traditional Chinese medicine regulating offer valuable insights promising directions for future studies on this subject.
Language: Английский
Citations
0
Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 324 - 324
Published: March 19, 2025
Background: Personalized cancer vaccines based on tumor neoantigens show great potential in immunotherapy due to their high safety and specificity. However, it is inherently difficult realize the efficiently targeted delivery of personalized antigen-presenting cells (APCs). Methods: This study aimed address these challenges by developing evaluating a vaccine antibody–antigen complexes, which was designed enhance antitumor effects increasing utilization APCs. Mice were immunized with carrier protein, keyhole limpet hemocyanin (KLH), induce production antibodies against KLH. Subsequently, mice KLH loaded immunoadjuvant CpG ODN underwent immunological analysis evaluate immune effects. Results: The results showed that preimmunization could promote uptake KLH-based vaccine, enhanced dendritic (DCs) macrophages (Mφs), strengthening T-cell responses tumors. Conclusions: Collectively, this work provides new idea for vaccines.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 545 - 572
Published: Jan. 1, 2025
Language: Английский
Citations
0