The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(6), P. 3626 - 3635
Published: Feb. 27, 2023
Rh(III)-catalyzed
synthesis
of
benzoisothiazole
spiropyrrolidinediones
using
sulfoximine
as
a
directing
group
under
C–H
activation
and
[4
+
1]
annulation
strategy
with
maleimides
coupling
partner
is
reported.
The
cyclization
reaction
was
compatible
various
substituted
maleimides.
deuterium-labeling
studies
were
performed
to
investigate
the
mechanism
reaction.
Dalton Transactions,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Natural
R
-carvone
was
converted
into
ruthenium
complexes
with
planar-chiral
arene
ligands.
Similar
to
the
classical
[(cymene)RuCl
2
]
complex,
they
catalyse
C–H
activation
reactions,
albeit
low
stereoselectivity.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
A
concise
synthesis
of
benzodiazepines
via
Rh(III)
catalyzed
C-H
activation/
[4
+
3]
annulation
easily
available
1-arylpyrazolidinones
with
allylic
acetal
has
been
developed.
The
was
employed
as
a
novel
3C
synthon
in
this
transformation.
Benzodiazepines
were
built
under
mild
reaction
conditions
high
efficiency
and
chemoselectivity.
atom-economy
accessible
substrates
reveal
potential
application.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Herein,
we
reported
a
DBU-catalyzed
cascade
and
sequential
[1
+
2
3]
annulation
of
malononitrile
with
α,β-unsaturated
ketones
to
access
polyfunctionalized
cyclohexanes
high
yield
excellent
diastereoselectivity
(>93%
yield,
>19:1
dr).
Intriguingly,
this
appears
be
the
new
strategy
for
using
either
as
2C
or
3C
synthon
react
dinucleophile
1C
construct
six-membered
carbocycles
in
one-pot
manner.
In
addition,
these
synthesized
compounds
suppressed
growth
phytopathogenic
fungi
vitro.
Among
them,
compound
3l
exhibited
broad
antifungal
activity,
which
possesses
potential
an
agricultural
agent.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 3345 - 3358
Published: Feb. 19, 2024
In
this
study,
a
modular
approach
toward
cyclic
sulfoximines
and
sulfondiimines
via
palladium-catalyzed
intramolecular
C-H/C-C
activation
reactions
was
reported.
Various
1,2-benzothiazines
including
bicyclic,
tricyclic,
highly
fused
ones,
ones
of
the
seven-membered
ring,
along
with
1,2-benzothiazine
1-imines
were
accessed
in
good
yields.
KIE
experiment
demonstrated
that
C-H
bond
cleavage
at
position
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1914 - 1919
Published: Feb. 29, 2024
A
catalytic
kinetic
resolution
of
sulfoximines
has
been
developed
through
chiral
phosphoric
acid-catalyzed
intramolecular
dehydrative
cyclizations.
variety
racemic
bearing
an
ortho-amidophenyl
moiety
underwent
asymmetric
cyclizations
using
this
method,
yielding
both
the
recovered
and
benzothiadiazine-1-oxide
products
with
good
to
high
enantioselectivities
(with
s-factor
up
61).
The
diverse
derivatizations
into
a
wide
range
S-stereogenic
center-containing
S,N-heterocycles
have
demonstrated
value
method.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(20)
Published: March 19, 2024
Abstract
Herein,
multiple
types
of
chiral
Os(II)
complexes
have
been
designed
to
address
the
appealing
yet
challenging
asymmetric
C(sp
3
)−H
functionalization,
among
which
Os(II)/Salox
species
is
found
be
most
efficient
for
precise
stereocontrol
in
realizing
amidation.
As
exemplified
by
enantioenriched
pyrrolidinone
synthesis,
such
tailored
catalyst
efficiently
enables
an
intramolecular
site‐/enantioselective
amidation
γ‐position
dioxazolone
substrates,
benzyl,
propargyl
and
allyl
groups
bearing
various
substituted
forms
are
well
compatible,
affording
corresponding
γ‐lactam
products
with
good
er
values
(up
99
:
1)
diverse
functionality
(>35
examples).
The
unique
performance
advantage
developed
system
terms
catalytic
energy
profile
induction
has
further
clarified
integrated
experimental
computational
studies.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(27), P. 5670 - 5675
Published: June 26, 2024
Axially
chiral
carboxylic
acids
are
important
motifs
in
catalysts
and
ligands.
We
herein
reported
the
synthesis
of
axially
via
Pd(II)-catalyzed
atroposelective
C-H
olefination
using
acid
as
native
directing
group.
A
broad
range
axial
biaryl-2-carboxylic
were
synthesized
good
yields
with
high
enantioselectivities
(up
to
84%
yield
99%
ee).
Gram-scale
reaction
further
transformation
reactions
also
provide
a
platform
for
synthetic
applications
this
method.
SynOpen,
Journal Year:
2023,
Volume and Issue:
07(04), P. 466 - 485
Published: Sept. 6, 2023
Abstract
Transition-metal-catalyzed
enantioselective
C–H
activation
provides
a
straightforward
strategy
to
synthesize
chiral
molecules
from
readily
available
sources.
In
this
graphical
review,
we
summarize
the
progress
on
half-sandwich
d6-metal
(CoIII,
RhIII,
IrIII,
RuII)-catalyzed
functionalization
reactions.
The
review
is
categorized
according
type
of
metal
catalyst
and
ligand
employed.
Representative
enantio-determining
models
catalytic
cycles
are
presented.
