The Prevalence and Pathophysiology of Chemical Sense Disorder Caused by the Novel Coronavirus DOI Creative Commons
Sareesh Naduvil Narayanan, Pooja Shivappa,

Sreeshma Padiyath

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: June 6, 2022

Emerging viral infections are a ceaseless challenge and remain global public health concern. The world has not yet come back to normal from the devastating effects of highly contagious pathogenic novel coronavirus, or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Olfactory taste dysfunction is common in patients infected by coronavirus. In light emergence different coronavirus variants, it important update prevalence pathophysiology these side effects. this review, articles published on olfactory disease (COVID-19) their possible pathophysiologic mechanisms have been reviewed reported. modulatory role SARS-CoV-2 variants chemical senses then described. clinical relevance sense disorder its long-term morbidity management also discussed.

Language: Английский

Prevalence of acute olfactory dysfunction differs between variants of SARS-CoV-2—results from chemosensitive testing in wild type, VOC alpha (B.1.1.7) and VOC delta (B.1617.2) DOI Creative Commons
Constantin A. Hintschich,

Veronika Vielsmeier,

Christopher Bohr

et al.

European Archives of Oto-Rhino-Laryngology, Journal Year: 2022, Volume and Issue: 279(11), P. 5445 - 5447

Published: June 29, 2022

Olfactory dysfunction is one of the leading symptoms COVID-19. Previous data suggest a different prevalence between wild type virus and its subsequent variants. Here, we report on prospective study to psychophysically compare olfactory function in acute SARS-CoV-2 infection type, VOC alpha delta.SARS-CoV-2 was confirmed by reverse-transcription quantitative real-time PCR variants were differentiated high-sensitive next-generation sequencing. Home-quarantined sent validated blinded smell identification test. A detailed instruction ensured correct self-administration.A total 125 patients included study. Patients with self-evaluated their significant lower visual analog score compared VOCs or delta (4.1 ± 1.5 vs. 6.8 2.9 7.3 0.9; p < 0.001). Likewise, difference hyposmia (wild type: 73%; alpha: 41%; 48%; 0.01) test (48 25% 70 23% 67 18%; could be seen side other side.In this study, both self-reports psychophysical testing revealed higher impairment delta.

Language: Английский

Citations

16
Autoimmunity, COVID-19 Omicron Variant, and Olfactory Dysfunction: A Literature Review DOI Creative Commons
Yonatan Shneor Patt, Lior Fisher, Paula David

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(4), P. 641 - 641

Published: Feb. 9, 2023

Smelling is a critical sense utilized daily. Consequently, smelling impairment or anosmia may lead to reduction in life quality. Systemic diseases and particular autoimmune conditions can impair olfactory function; among others are Lupus Erythematosus, Sjögren Syndrome, Rheumatoid Arthritis. Interactions between the process immune systems cause this phenomenon. Alongside conditions, recent COVID-19 pandemic, was also described as prevalent infection symptom. Nevertheless, occurrence of significantly less common Omicron-infected patients. Several theories have been proposed explain One possibility that Omicron variant preferentially enters host cells via endocytosis, rather than plasma cell membrane fusion. This endosomal pathway dependent on activation Transmembrane serine protease 2 (TMPRSS2), expressed at epithelium. As result, reduced efficiency penetrating epithelium, leading lower prevalence anosmia. Furthermore, changes known be associated with inflammatory conditions. The elicits robust response, believed reduce probability review elaborates commonalities differences omicron-associated

Language: Английский

Citations

9
The dynamics of circulating SARS-CoV-2 lineages in Bogor and surrounding areas reflect variant shifting during the first and second waves of COVID-19 in Indonesia DOI Creative Commons
Anggia Prasetyoputri, Anik Budhi Dharmayanthi, Syam Budi Iryanto

et al.

PeerJ, Journal Year: 2022, Volume and Issue: 10, P. e13132 - e13132

Published: March 22, 2022

Background Indonesia is one of the Southeast Asian countries with high case numbers COVID-19 up to 4.2 million confirmed cases by 29 October 2021. Understanding genome SARS-CoV-2 crucial for delivering public health intervention as certain variants may have different attributes that can potentially affect their transmissibility, well performance diagnostics, vaccines, and therapeutics. Objectives We aimed investigate dynamics circulating over a 15-month period in Bogor its surrounding areas correlation first second wave Indonesia. Methods Nasopharyngeal oropharyngeal swab samples collected from suspected patients Bogor, Jakarta Tangerang were infection RT-PCR. RNA those subjected whole sequencing using ARTIC Network protocol sequencer platform Oxford Nanopore Technologies (ONT). Results successfully identified 16 lineages six clades out 202 (male n = 116, female 86). Genome analysis revealed Indonesian lineage B.1.466.2 dominated during ( 48, 23.8%) while Delta (AY.23, AY.24, AY.39, AY.42, AY.43 dan AY.79) dominant 53, 26.2%) following highest number In spike protein gene, S_D614G S_P681R changes both variants, N439K was only observed 44) B.1.470 1). Additionally, S_T19R, S_E156G, S_F157del, S_R158del, S_L452R, S_T478K, S_D950N S_V1264L detected consistent being characteristic general. Conclusions demonstrated shift wave, which surpassed pandemic. Higher proportion unique mutations compared indicated potential mutational effects on viral transmissibility correlated higher incidence cases. Genomic surveillance especially should be continuously conducted rapidly inform decision making support outbreak preparedness, prevention, response.

Language: Английский

Citations

14
SARS-CoV-2 and Other Respiratory Viruses in Human Olfactory Pathophysiology DOI Creative Commons
Serigne Fallou Wade, Abou Abdallah Malick Diouara,

Babacar Ngom

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 540 - 540

Published: March 7, 2024

Acute respiratory viruses (ARVs) are the leading cause of diseases in humans worldwide. High-risk individuals, including children and elderly, could potentially develop severe illnesses that result hospitalization or death worst case. The most common ARVs Human syncytial virus, Metapneumovirus, Parainfluenza Virus, rhinovirus, coronaviruses (including SARS MERS CoV), adenoviruses, Bocavirus, enterovirus (-D68 71), influenza viruses. olfactory deficits due to ARV infection a symptom among patients. This review provides an overview role SARS-CoV-2 other development human pathophysiology. We highlight critical need understand signaling underlying dysfunction therapeutics for this wide-ranging category AVRs restore altered loss smell affected

Language: Английский

Citations

2
The Prevalence and Pathophysiology of Chemical Sense Disorder Caused by the Novel Coronavirus DOI Creative Commons
Sareesh Naduvil Narayanan, Pooja Shivappa,

Sreeshma Padiyath

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: June 6, 2022

Emerging viral infections are a ceaseless challenge and remain global public health concern. The world has not yet come back to normal from the devastating effects of highly contagious pathogenic novel coronavirus, or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Olfactory taste dysfunction is common in patients infected by coronavirus. In light emergence different coronavirus variants, it important update prevalence pathophysiology these side effects. this review, articles published on olfactory disease (COVID-19) their possible pathophysiologic mechanisms have been reviewed reported. modulatory role SARS-CoV-2 variants chemical senses then described. clinical relevance sense disorder its long-term morbidity management also discussed.

Language: Английский

Citations

10