The Relationship between Sleep Disturbance and Early Alzheimer’s Disease – Mild Cognitive Impairment DOI Open Access
Mengzhen Zhou

Published: Jan. 1, 2023

During sleep, the brain can clear toxins related to Alzheimer’s disease. Compared with baseline without sleep disorder, subjects disorder have a 1.49-fold increased risk of There is two-way relationship between sleep/wakefulness and disease pathology. Sleep plays an important role in memory consolidation. Research shows that may impact on symptoms course Therefore, we need better understand mechanism cognitive behavioral impairment delay progress by improving sleep. The individuals higher than disorder; Improving improve level development impairment; DORA effective strategy neurodegeneration patients

Language: Английский

Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain DOI Creative Commons
Lisa C. Lyons, Yann Vanrobaeys, Ted Abel

et al.

Journal of Neurochemistry, Journal Year: 2023, Volume and Issue: 166(1), P. 24 - 46

Published: Feb. 18, 2023

Abstract In countries around the world, sleep deprivation represents a widespread problem affecting school‐age children, teenagers, and adults. Acute more chronic restriction adversely affect individual health, impairing memory cognitive performance as well increasing risk progression of numerous diseases. mammals, hippocampus hippocampus‐dependent are vulnerable to effects acute deprivation. Sleep induces changes in molecular signaling, gene expression may cause dendritic structure neurons. Genome wide studies have shown that alters transcription, although pool genes affected varies between brain regions. More recently, advances research drawn attention differences regulation level transcriptome compared with mRNA associated ribosomes for protein translation following Thus, addition transcriptional changes, also affects downstream processes alter translation. this review, we focus on multiple levels through which impacts regulation, highlighting potential post‐transcriptional translational be by Understanding impacted is essential future development therapeutics mitigate loss. image

Language: Английский

Citations

29
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease DOI Creative Commons
Christopher D. Morrone, Radha Raghuraman, S. Abid Hussaini

et al.

Molecular Neurodegeneration, Journal Year: 2023, Volume and Issue: 18(1)

Published: April 21, 2023

Abstract Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation and clearance. However, the contribution failed to neuronal circuit dysfunction an emerging concept in neurodegenerative research will prove critical understanding cognitive decline. Our objective convey disease progression with growing evidence for bidirectional relationship sleep disruption failure. Proteostasis tauopathy disrupts neurons that regulate sleep–wake cycle, which presents behavior as impaired slow wave rapid eye movement patterns. Subsequent loss further impairs Sleep defined seen early many disorders contributes memory impairments disease. Canonical pathological hallmarks, β-amyloid, tau, directly disrupt sleep, neurodegeneration locus coeruleus, hippocampal hypothalamic from tau proteinopathy causes circuitry sleep. Acting positive-feedback-loop, circadian rhythm then increase spread β-amyloid through proteasome, autophagy, unfolded response glymphatic This phenomenon extends beyond interactions impairment homeostasis TDP-43, α-synuclein, FUS, huntingtin proteins, implicating important consideration array diseases cases mixed neuropathology. Critically, dynamics this interaction environment are not fully elucidated deserving discussion research. Finally, we propose sleep-enhancing therapeutics potential interventions promoting healthy proteostasis, including clearance, mechanistically linking these processes. With clinical preclinical research, dynamic diagnostic therapeutic framework, informing precise single- combinatorial-treatments other brain disorders. Graphical

Language: Английский

Citations

27
Day‐to‐day sleep variability with Alzheimer's biomarkers in at‐risk elderly DOI

Andrée‐Ann Baril,

Cynthia Picard, Anne Labonté

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 1, 2024

Language: Английский

Citations

6
Iron-catalyzed intramolecular C–H amination for the synthesis of N–H carbazoles and indoles DOI
Zhenglin Wang,

Yun‐Hao Zhang,

Jun‐Yu Huang

et al.

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(11), P. 4463 - 4468

Published: Jan. 1, 2023

An iron-catalyzed intramolecular dehydrogenative coupling for the synthesis of N–H carbazoles and indoles with excellent functional group tolerance using air as terminal oxidant is reported.

Language: Английский

Citations

14
Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition DOI Creative Commons
Mengzhen Zhou,

Shi Tang

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 9

Published: Feb. 1, 2023

Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating sleep-wake cycle. The overexpression of orexinergic system may be related to pathology sleep/wakefulness disorders Alzheimer's disease (AD). In AD patients, increase cerebrospinal fluid orexin levels associated with parallel sleep deterioration. Dual receptor antagonist (DORA) can not only treat sleep-wakefulness disorder but also improve performance patients cognitive behavior disorder. It critical clarify AD, study its relationship decline and evaluate safety efficacy DORA.

Language: Английский

Citations

13
Risk of neurodegenerative diseases in patients with sleep disorders: A nationwide population-based case-control study DOI
Wei Lin, Yu‐Kai Lin, Fu‐Chi Yang

et al.

Sleep Medicine, Journal Year: 2023, Volume and Issue: 107, P. 289 - 299

Published: May 19, 2023

Language: Английский

Citations

13
CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury DOI Creative Commons

Jiayuanyuan Fu,

Mengran Du,

Biying Wu

et al.

Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Abstract Sleep disorders (SD) are common sequelae following traumatic brain injury (TBI) and may be linked to mitochondrial oxidative stress dysregulation after TBI. Increasing evidence showed that circRNAs play crucial roles in nervous system diseases. However, the involvement of sleep disturbances TBI is not characterized. In this study, differentially expressed were identified by RNA sequencing. quality patients was assessed through scales electroencephalograms. Further experiments conducted investigate role circItm2b. We found circItm2b elevated involved disorder patients. Over-expression might aggravate mice Mechanically, regulates Nox4 expression binding Sirt1, which influences stress-caused circadian protein losses. Moreover, knockdown attenuated stress-induced proteins losses via circItm2b/Sirt1/Nox4 axis TBI, suggest serve as a prognostic marker for improving represent promising therapeutic target TBI-related disturbances.

Language: Английский

Citations

0
The electrophysiological and neuropathological profiles of cerebellum in APPswe/PS1ΔE9 mice: A hypothesis on the role of cerebellum in Alzheimer's disease DOI
Hang Yu, Manli Wang,

Qiu Yang

et al.

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 19(6), P. 2365 - 2375

Published: Dec. 5, 2022

We propose the hypothesis that cerebellar electrophysiology and sleep-wake cycles may be altered at early stage of Alzheimer's disease (AD), proceeding amyloid-β neuropathological hallmarks. The electrophysiologic characteristics cerebellum thereby might served as a biomarker in prepathological detection AD. Sleep disturbances are common preclinical AD patients, has been implicated regulation by several pioneer studies. Additionally, recent studies suggest structure function stages AD, indicating involved disease's progression. used APPswe /PS1ΔE9 mice model monitored analyzed electroencephalogram data, assessed profiles mice. Our establish linkage between potentially providing new perspectives on pathogenesis disease.

Language: Английский

Citations

10
Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease DOI Open Access
Susana Lozano-Tovar, Yaneth Rodríguez‐Agudelo, David José Dávila‐Ortiz de Montellano

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(5), P. 4412 - 4412

Published: March 1, 2023

Alzheimer’s disease (AD) is characterized by the presence of neuropsychiatric or behavioral and psychological symptoms dementia (BPSD). BPSD have been associated with APOE_ε4 allele, which also major genetic AD risk factor. Although involvement some circadian genes orexin receptors in sleep disorders has studied psychiatric pathologies, including AD, there are no studies considering gene–gene interactions. The associations one variant PER2, two PER3, OX2R APOE were evaluated 31 patients cognitively healthy subjects. Genotyping was performed using real-time PCR capillary electrophoresis from blood samples. allelic-genotypic frequencies variants calculated for sample study. We explored between allelic based on NPI, PHQ-9 sleeping questionnaires. Our results showed that allele an (p = 0.03). remaining did not reveal significant differences controls. PER3_rs228697 a nine-fold increased rhythm sleep–wake Mexican patients, our interaction analysis identified novel PERIOD gene variants. These findings need to be further confirmed larger

Language: Английский

Citations

5
A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease DOI Creative Commons
Mengfei Li, Zhenzhen Jiang, Ru Wen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Feb. 2, 2023

Objective The purpose of this study was to examine the current state application imaging in sleep research degenerative disease, as well hotspots and trends. Materials methods A search conducted on Web Science Core Collection (WoSCC) between 1 September 2012, 31 August 2022 for literature related imaging. This analyzed 7,679 articles published field over past 10 years, using CiteSpace analyze tendencies, countries, institutions, authors, hotspots. Results There were by 566 institutions located 135 countries 1,428 journals; number increasing a yearly basis. According keyword analysis, direction focused effects diseases sleep, such Parkinson’s Alzheimer’s small vessel disease. evaluation found that insomnia, quality, rapid eye movement behavior disorder top trends field. Conclusion growing body has disorders caused diseases. In research, magnetic resonance functional brain represents reliable method. future, more aging-related may be subject sleep-related could provide convenient evidence respect.

Language: Английский

Citations

4