Hypertension in Pregnancy,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Sept. 24, 2024
Preeclampsia
and
eclampsia
are
severe
pregnancy
disorders
marked
by
hypertension
potential
organ
damage.
The
etiological
basis
of
preeclampsia
is
not
fully
understood.
Previous
studies
have
revealed
a
link
between
sleep
abnormality
preeclampsia/eclampsia,
but
the
causal
relationship
remains
unclear.
In
this
study,
we
explored
genetic
links
preeclampsia/eclampsia
using
genome-wide
association
study
(GWAS)
summary
data
Mendelian
randomization
(MR)
analysis.
Journal of Epidemiology and Global Health,
Journal Year:
2024,
Volume and Issue:
14(1), P. 184 - 192
Published: Feb. 15, 2024
Accurately
detecting
the
quantity
of
microorganisms
in
hospital
purified
water
is
significant
importance
for
early
identification
microbial
contamination
and
reducing
occurrence
water-borne
infections.
The
choice
detection
method
a
prerequisite
ensuring
accurate
results.
Traditional
Plate
Count
Agar
(PCA)
belongs
to
high-nutrient
medium,
there
may
be
limitations
terms
accuracy
or
sensitivity
water.
On
other
hand,
Reasoner's
2A
agar
(R2A)
has
characteristics,
such
as
low-nutrient
levels,
low
cultivation
temperature,
extended
incubation
time,
providing
advantages
promoting
growth
aquatic
microorganisms.
This
study,
through
comparing
differences
total
colony
counts
between
two
methods,
aims
select
more
suitable
microorganisms,
offering
new
practical
insights
accurately
count
heterotrophic
bacteria
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
2(1)
Published: March 8, 2025
We
examine
the
relationship
between
sleep,
glymphatics
and
Alzheimer's
disease
(AD),
recent
work
questioning
glymphatic
clearance
during
sleep.
highlight
a
need
for
understanding
and/or
other
mechanism
of
review
flow
measurement
methods.
Further,
we
explore
dual
orexin
receptor
antagonists
(DORAs)
potential
to
mitigate
AD
sleep
disturbances
enhance
clearance.
Further
research
could
elucidate
linkage
DORAs,
improved
reducing
pathophysiology.
Journal of Huntington s Disease,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
The
glymphatic
system,
a
macroscopic
waste
clearance
network
in
the
brain,
plays
vital
role
maintaining
neuronal
health
and
brain
homeostasis.
Functionally
analogous
to
lymphatic
system
other
organs,
term
“glymphatic”
combines
“glial”
“lymphatic.”
This
facilitates
exchange
of
cerebrospinal
fluid
(CSF)
interstitial
(ISF)
parenchyma,
aiding
removal
soluble
proteins
metabolites
while
distributing
essential
nutrients
signaling
molecules.
Its
functionality
is
closely
tied
aquaporin
4
(AQP4)
water
channels,
located
primarily
on
astrocytic
endfeet,
which
mediate
movement
between
CSF
ISF.
Proper
function
relies
cellular
distribution
AQP4
channels
its
astroglial
endfeet
polarization.
Emerging
evidence
links
dysfunction
several
neurodegenerative
disorders,
including
Huntington's
disease
(HD).
Understanding
HD
pathogenesis
could
provide
novel
insights
into
new
therapeutic
approaches.
review
examines
connection
HD,
highlighting
future
research
directions
advancement
for
HD.
It
explores
pharmacological
interventions
lifestyle
modifications
aimed
at
optimizing
improve
management.
This
review
examines
the
complex
relationship
between
sleep,
glymphatic
system
and
Alzheimer’s
disease
(AD)
pathogenesis.
It
explores
recent
work
calling
into
question
mechanism
of
clearance
during
thus
for
further
research
to
understand
mechanisms
and/or
uncover
true
sleep.
Methods
measuring
flow
are
reviewed,
suggesting
that
magnetic
resonance
imaging
(MRI)
may
be
best
approach
resolve
this
controversy.
Furthermore,
therapeutic
potential
dual
orexin
receptor
antagonists
(DORAs)
in
mitigating
sleep
disturbances
associated
with
AD.
DORAs
promote
thereby
enhance
regardless
precise
(glymphatic
or
other),
offering
a
promising
avenue
slowing
AD
progression
improving
long
term
patient
outcomes.
More
is
crucial
elucidate
linkage
DORAs,
improved
facilitating
remediation
pathophysiology.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 21, 2024
Abstract
Orexins
are
wake-promoting
neuropeptides
that
originate
from
hypothalamic
neurons
projecting
to
widespread
brain
areas
throughout
the
central
nervous
system.
They
modulate
various
physiological
functions
via
their
orexin
1
(OXR1)
and
2
(OXR2)
receptors,
including
sleep-wake
rhythm
but
also
cognitive
such
as
memory
formation.
Here,
we
provide
a
detailed
analysis
of
OXR1
OXR2
mRNA
expression
profiles
in
dorsal
hippocampus
key
region
for
formation,
using
RNAscope
multiplex
situ
hybridization.
Interconnected
subareas
relevant
cognition
medial
prefrontal
cortex
nucleus
reuniens
thalamus
were
assessed
well.
Both
receptor
types
display
distinct
profiles,
with
highest
percentage
mRNA-positive
cells
hilus
dentate
gyrus.
content
per
cell
was
slightly
modulated
at
selected
time
points
over
12
h
light/
dark
light
phase.
Using
RNAScope
quantitative
polymerase
chain
reaction
approaches,
began
address
cell-type
specific
hilar
GABAergic
interneurons.
The
both
subtypes
within
hippocampal
circuits
an
interesting
basis
future
interventional
studies
on
function
spatial
contextual
memory.
