Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
Abstract
Gouty
arthritis
is
a
prevalent
inflammatory
illness.
Gout
attacks
begin
when
there
an
imbalance
in
the
body’s
uric
acid
metabolism,
which
leads
to
urate
buildup
and
development
of
ailment.
A
family
conserved,
short
non-coding
RNAs
known
as
microRNAs
(miRNAs)
can
regulate
post-transcriptional
protein
synthesis
by
attaching
3′
untranslated
region
(UTR)
messenger
RNA
(mRNA).
An
increasing
amount
research
pointing
miRNAs
potential
players
several
diseases,
including
gouty
arthritis.
may
influence
progression
disease
regulating
immune
function
responses.
This
review
mainly
focused
on
how
they
contribute
It
also
looked
at
could
be
used
diagnostic,
prognostic,
therapeutic
targets.
Non-coding RNA Research,
Journal Year:
2023,
Volume and Issue:
8(3), P. 302 - 314
Published: March 21, 2023
Long
non-coding
RNA
(LncRNA)
telomerase
component
(TERC)
has
telomerase-dependent
and
independent
activity
in
numerous
cancer
types.
The
present
study
purposes
to
demonstrate
the
role
of
lncRNA
TERC
as
a
diagnostic
serum
biomarker
colorectal
(CRC)
patients
molecular
mechanism
inducing
tumor
CRC
cell
lines.PCR
array
was
performed
examine
lncRNAs
dysregulated
CRC.
LncRNA
expression
level
evaluated
70
35
control
subjects
using
RT-qPCR.
Then
transfection
build
down-expression
models
TERC.
ROC
curve
analysis
applied
assess
value
In
addition,
RT-qPCR
used
detect
β-catenin
mRNA.
Moreover,
ELISA
Western
blot
were
protein
sera
lines.
biological
functions
such
growth
migration
cells
assessed
wound
healing
assay.
Cell
cycle
apoptosis
flow
cytometry.The
is
overexpressed
with
high
stage
discrimination
accuracy.
Furthermore,
upregulated
lines
silencing
induced
arrest
inhibited
migration.
inhibition
reduces
levels.The
could
be
considered
an
early
stages
good
ability
discriminate
between
stages.
induces
by
promoting
evading
elevating
protein.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 9, 2024
Interferon
Regulatory
Factors
(IRFs),
a
family
of
transcription
factors,
profoundly
influence
the
immune
system,
impacting
both
physiological
and
pathological
processes.
This
review
explores
diverse
functions
nine
mammalian
IRF
members,
each
featuring
conserved
domains
essential
for
interactions
with
other
factors
cofactors.
These
allow
IRFs
to
modulate
broad
spectrum
processes,
encompassing
host
defense,
response,
cell
development.
Conversely,
their
pivotal
role
in
regulation
implicates
them
pathophysiology
various
diseases,
such
as
infectious
autoimmune
disorders,
metabolic
cancers.
In
this
context,
display
dichotomous
nature,
functioning
tumor
suppressors
promoters,
contingent
upon
specific
disease
milieu.
Post-translational
modifications
IRFs,
including
phosphorylation
ubiquitination,
play
crucial
modulating
function,
stability,
activation.
As
prospective
biomarkers
therapeutic
targets,
present
promising
opportunities
intervention.
Further
research
is
needed
elucidate
precise
mechanisms
governing
regulation,
potentially
pioneering
innovative
strategies,
particularly
cancer
treatment,
where
equilibrium
activities
paramount
importance.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 18, 2025
Abstract
Globally,
the
incidence
and
death
rates
associated
with
cancer
persist
in
rising,
despite
considerable
advancements
therapy.
Although
some
malignancies
are
manageable
by
a
mix
of
chemotherapy,
surgery,
radiation,
targeted
therapy,
most
malignant
tumors
either
exhibit
poor
responsiveness
to
early
identification
or
endure
post-treatment
survival.
The
prognosis
for
prostate
(PCa)
is
unfavorable
since
it
perilous
lethal
malignancy.
capacity
phytochemical
nutraceutical
chemicals
repress
oncogenic
lncRNAs
activate
tumor
suppressor
has
garnered
significant
attention
as
possible
strategy
diminish
development,
proliferation,
metastasis,
invasion
cells.
A
potential
technique
treat
enhance
sensitivity
cells
existing
conventional
therapies
use
phytochemicals
anticancer
characteristics.
Functional
studies
indicate
that
modulate
drug
resistance,
stemness,
invasion,
angiogenesis,
proliferation
via
interactions
suppressors
oncoproteins.
Among
them,
numerous
lncRNAs,
such
HOTAIR,
PlncRNA1,
GAS5,
MEG3,
LincRNA-21,
POTEF-AS1,
support
development
PCa
through
many
molecular
mechanisms,
including
modulation
regulation
various
signal
pathways
like
PI3K/Akt,
Bax/Caspase
3,
P53,
MAPK
cascade,
TGF-β1.
Other
particular,
MALAT-1,
CCAT2,
DANCR,
LncRNA-ATB,
ZEB1-AS1,
SChLAP1,
H19,
key
players
regulating
aforementioned
processes.
Natural
substances
have
shown
promising
benefits
against
altering
essential
signaling
pathways.
overexpression
advanced
TNM
stage,
chemoresistance,
reduced
LncRNAs
possess
crucial
clinical
transitional
implications
PCa,
diagnostic
prognostic
biomarkers,
well
medicinal
targets.
To
impede
progression
beneficial
target
aberrant
long
non-coding
RNAs
using
antisense
oligonucleotides
small
interfering
(siRNAs).
This
prevents
them
from
transmitting
harmful
messages.
In
summary,
several
precision
medicine
approaches
may
be
used
rectify
dysfunctional
lncRNA
regulatory
circuits,
so
improving
detection
eventually
facilitating
conquest
this
disease.
Due
their
presence
biological
fluids
tissues,
they
serve
novel
biomarkers.
Enhancing
treatments
mitigates
resistance
chemotherapy
radiation.
