A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO DOI Creative Commons
Dongning Liu, Xiaoxiao Yang, Binghe Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Carbon monoxide (CO) is endogenously produced with a range of pharmacological activities. Sensitive and selective detection CO critical to studying its biology. Since the first report fluorescent probe in 2012, more than 100 papers on this topic have appeared. Noteworthy such work widespread use two commercially available ruthenium–carbonyl complexes (CORM-2 CORM-3) as surrogates. Unfortunately, these CORMs are chemically very reactive preferentially release CO2 but not CO, unless presence nucleophile. As result, there "two tales" reported probes: those that detect only CORM used CO. In addition, because their lack reliable production fast degradation an aqueous solution, question what "detecting CORM-2 or CORM-3" really means context research. Additionally, for applying probes detecting low levels (often nanomolar) vivo, reaction kinetics prerequisite meaningful results. Perspective, we discuss detail issues understanding evolutionary nature scientific discoveries aim preventing further confusion.

Language: Английский

Carbon Monoxide as a Potential Therapeutic Agent: A Molecular Analysis of Its Safety Profiles DOI Creative Commons
Shubham Bansal, Dongning Liu, Qiyue Mao

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(12), P. 9789 - 9815

Published: June 12, 2024

Carbon monoxide (CO) is endogenously produced in mammals, with blood concentrations the high micromolar range hemoglobin-bound form. Further, CO has shown therapeutic effects various animal models. Despite its reputation as a poisonous gas at concentrations, we show that should have wide enough safety margin for applications. The analysis considers large number of factors including levels endogenous CO, comparison to commonly encountered biomolecules or drugs, anticipated enhanced profiles when delivered via noninhalation mode, and amount data from human clinical trials. It be emphasized having use does not mean it benign safe general public, even low doses. We defer latter public health experts. Importantly, this Perspective written drug discovery professionals public.

Language: Английский

Citations

23
Carbon Monoxide Poisoning: Diagnosis, Prognostic Factors, Treatment Strategies, and Future Perspectives DOI Creative Commons

Mohd Afzal,

Shagun Agarwal, Rabab Hassan Elshaikh

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 581 - 581

Published: Feb. 27, 2025

Carbon monoxide (CO) poisoning is a significant public health issue, with diagnosis often complicated by non-specific symptoms and limited access to specialised tools. Early detection vital for preventing long-term complications. The review examines diagnostic challenges, prognostic factors, management strategies, future advancements in CO poisoning. It highlights the limitations of current techniques such as blood carboxyhaemoglobin levels pulse CO-oximetry, while exploring emerging methods rapid detection. Prognosis influenced exposure severity delayed treatment, which increases risk neurological damage. Hyperbaric oxygen therapy (HBOT) remains primary treatment but not always accessible. Advances portable CO-oximeters biomarkers offer potential improved early monitoring. Addressing resource refining protocols are crucial better patient outcomes. Future research should focus on personalised strategies integration modern technologies enhance care.

Language: Английский

Citations

1
Metal-Free CO Prodrugs Activated by Molecular Oxygen Protect against Doxorubicin-Induced Cardiomyopathy in Mice DOI Creative Commons
Xiaoxiao Yang,

Wen Lu,

Rodrigo Wagner Alves de Souza

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Carbon monoxide has been extensively studied for its various therapeutic activities in cell cultures and animal models. Great efforts have made to develop noninhalational approaches easy controlled CO delivery. Herein, we introduce a novel metal-free prodrug approach that releases under near-physiological conditions. from the quinone-derived prodrugs is initiated by general acid/base-catalyzed tautomerization followed oxidation molecular oxygen form key norbornadienone intermediate, leading cheletropic release only an aerobic environment. Representative analog

Language: Английский

Citations

5
Plants’ Impact on the Human Brain—Exploring the Neuroprotective and Neurotoxic Potential of Plants DOI Creative Commons

Georgiana Moise,

Alex-Robert Jîjie, Elena-Alina Moacă

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1339 - 1339

Published: Oct. 7, 2024

Plants have long been recognized for their potential to influence neurological health, with both neuroprotective and neurotoxic properties. This review explores the dual nature of plant-derived compounds impact on human brain.

Language: Английский

Citations

4
Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory DOI Open Access
Constantin Munteanu, Anca‐Irina Galaction, Gelu Onose

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3131 - 3131

Published: March 28, 2025

Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function neurotransmitter release neuronal circuits. By synthesizing findings from animal cellular models, we investigate impacts of enzymatic production exogenous on excitatory currents, long-term potentiation, intracellular calcium signaling. Data suggest that interacts directly with subunits, altering excitability. Simultaneously, promotes neurotransmitters such glutamate GABA, shaping dynamics plasticity. Furthermore, reports indicate disruptions metabolism contribute to cognitive impairments neurodegenerative disorders, underscoring potential therapeutic value targeting H2S-mediated Although precise mechanisms H2S-induced changes strength remain elusive, growing body positions significant regulator formation processes. calls for more rigorous exploration into underpinnings paving way novel pharmacological interventions dysfunction.

Language: Английский

Citations

0
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide DOI
Nicola Bauer, Qiyue Mao,

Aditi Vashistha

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Carbon monoxide (CO) is an endogenous signaling molecule. It produced via heme degradation by oxygenase (HMOX), releasing stoichiometric amounts of CO, iron, and biliverdin (then bilirubin). The HMOX‐CO axis has long been shown to offer beneficial effects modulating inflammation, proliferation cell death as they relate tissue organ protection. Recent years have seen a large number studies examining CO pharmacology, its molecular targets, cellular mechanisms action, pharmacokinetics, detection methods using various delivery modalities including inhaled gas, solutions, types donors. Unfortunately, one widely used donor type includes four commercially available carbonyl complexes with metal or borane, CORM‐2 (Ru 2+ ), CORM‐3 CORM‐A1 (BH 3 CORM‐401 (Mn + which minimal and/or unpredictable production extensive CO‐independent chemical reactivity biological activity. As result, not all “CO activities” in the literature can be attributed CO. In this review, we summarize key findings based on gas solution for certainty active principal avoid data contamination resulting from confirmed potential reactivities activities “carrier” portion CORMs. Along similar line, discuss interesting research areas brain newly proposed CO/HMOX/dopamine role cognitive stimulation circadian rhythm. This review critical future development field steering clear complications caused chemically reactive molecules.

Language: Английский

Citations

0
A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO DOI Creative Commons
Dongning Liu, Xiaoxiao Yang, Binghe Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Carbon monoxide (CO) is endogenously produced with a range of pharmacological activities. Sensitive and selective detection CO critical to studying its biology. Since the first report fluorescent probe in 2012, more than 100 papers on this topic have appeared. Noteworthy such work widespread use two commercially available ruthenium–carbonyl complexes (CORM-2 CORM-3) as surrogates. Unfortunately, these CORMs are chemically very reactive preferentially release CO2 but not CO, unless presence nucleophile. As result, there "two tales" reported probes: those that detect only CORM used CO. In addition, because their lack reliable production fast degradation an aqueous solution, question what "detecting CORM-2 or CORM-3" really means context research. Additionally, for applying probes detecting low levels (often nanomolar) vivo, reaction kinetics prerequisite meaningful results. Perspective, we discuss detail issues understanding evolutionary nature scientific discoveries aim preventing further confusion.

Language: Английский

Citations

2