When the solution becomes the problem: a review on antimicrobial resistance in dairy cattle
Future Microbiology,
Journal Year:
2024,
Volume and Issue:
19(10), P. 903 - 929
Published: April 25, 2024
Antibiotics'
action,
once
a
'magic
bullet',
is
now
hindered
by
widespread
microbial
resistance,
creating
global
antimicrobial
resistance
(AMR)
crisis.
A
primary
driver
of
AMR
the
selective
pressure
from
use.
Between
2000
and
2015,
antibiotic
consumption
increased
65%,
reaching
34.8
billion
tons,
73%
which
was
used
in
animals.
In
dairy
cattle
sector,
antibiotics
are
crucial
for
treating
diseases
like
mastitis,
posing
risks
to
humans,
animals
potentially
leading
environmental
contamination.
To
address
AMR,
strategies
dry
cow
therapy,
alternative
treatments
(nanoparticles,
phages)
waste
management
innovations
emerging.
However,
most
solutions
development,
emphasizing
urgent
need
further
research
tackle
farms.
Language: Английский
Role of biofilms in antimicrobial resistance of the bacterial bovine respiratory disease complex
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: June 12, 2024
An
increase
in
chronic,
non-responsive
bovine
respiratory
disease
(BRD)
infections
North
American
feedlot
cattle
is
observed
each
fall,
a
time
when
are
administered
multiple
antimicrobial
treatments
for
BRD.
A
number
of
factors
responsible
BRD
treatment
failure,
with
formation
biofilms
possibly
being
one.
It
widely
accepted
that
play
role
chronic
humans
and
it
has
been
hypothesized
they
the
default
lifestyle
most
bacteria.
However,
research
on
bacterial
associated
livestock
scarce
significant
knowledge
gaps
exist
our
understanding
their
AMR
complex.
The
four
main
species
complex,
Mannheimia
haemolytica
,
Pasteurella
multocida
Histophilus
somni
Mycoplasma
bovis
able
to
form
vitro
there
evidence
at
least
H.
retains
this
ability
vivo
.
need
elucidate
whether
biofilm-forming
contributes
pathogenicity
failure
Overall,
better
possible
clinical
could
assist
prevention
management
cattle.
We
review
discuss
current
bacteria
biofilm
biology,
study
methodologies,
relationship
AMR.
Language: Английский
Investigation of the safety and protective efficacy of an attenuated and marker M. bovis-BoHV-1 combined vaccine in bovines
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 4, 2024
Bovine
respiratory
disease
(BRD)
is
one
of
the
most
common
diseases
in
cattle
industry
worldwide;
it
caused
by
multiple
bacterial
or
viral
coinfections,
which
Mycoplasma
bovis
(
M.
)
and
bovine
herpesvirus
type
1
(BoHV-1)
are
notable
pathogens.
Although
live
vaccines
have
demonstrated
better
efficacy
against
BRD
induced
both
pathogens,
there
no
combined
marker
vaccines.
Therefore,
we
developed
an
attenuated
-BoHV-1
vaccine
based
on
HB150
BoHV-1
gG-/tk-
strain
previously
constructed
our
lab
evaluated
rabbits.
This
study
aimed
to
further
evaluate
its
safety
protective
using
different
antigen
ratios.
After
immunization,
all
vaccinated
had
a
normal
rectal
temperature
mental
status
without
symptoms.
CD4
+
,
CD8
CD19
cells
significantly
increased
immunized
higher
humoral
cellular
immune
responses,
expression
key
cytokines
such
as
IL-4,
IL-12,
TNF-α,
IFN-γ
can
be
promoted
after
vaccination.
The
1.0
×
10
8
CFU
6
TCID
50
elicited
antibodies
while
increasing
IgG
immunity
challenge.
In
conclusion,
was
clinically
safe
calves;
mix
promising
due
low
amount
shedding
highest
responses
compared
with
others.
introduces
for
application
industry.
Language: Английский
Measurement of Human and Bovine Exhaled Breath Condensate pH Using Polyaniline-Modified Flexible Inkjet-Printed Nanocarbon Electrodes
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(39), P. 40841 - 40856
Published: Sept. 16, 2024
The
collection,
processing,
and
electrochemical
analysis
of
exhaled
breath
condensate
(EBC)
from
healthy
human
animal
subjects
is
reported
on.
EBC
a
biospecimen
potentially
rich
in
biomarkers
respiratory
disease.
pH
was
analyzed
potentiometrically
using
disposable
polyaniline
(PANI)-modified
inkjet-printed
(IJP)
carbon
electrode.
Comparison
measurements
were
performed
commercial
screen-printed
(SPC)
PANI-modified
electrodes
exhibited
reproducible
near-Nernstian
responses
for
values
between
2
9
with
slopes
-50
to
-60
mV/dec.
IJP
electrode
faster
response
time
superior
reproducibility
the
modified
SPC
In
proof-of-concept
studies,
found
be
6.57
±
0.09
bovine
5.9
0.2.
All
determined
good
agreement
micro
glass
An
RTube
device
used
collect
humans
while
calves
field.
volumes
0.5-2
mL
5-6
min
tidal
breathing
collected
animals.
(17
animals)
depends
on
their
age
1
weeks
ranging
5.3
7.2.
A
distinct
alkaline
shift
observed
many
animals
around
20
days
age.
also
ambient
temperature
humidity
at
collection.
results
indicate
that
outperform
provide
accurate
measurement
across
various
types.
Language: Английский
Relationship between capsule production and biofilm formation by Mannheimia haemolytica, and establishment of a poly-species biofilm with other Pasteurellaceae
Biofilm,
Journal Year:
2024,
Volume and Issue:
8, P. 100223 - 100223
Published: Sept. 28, 2024
Language: Английский
The Safety and Protective Efficacy Evaluation of an Attenuated M. bovis–BoHV-1 Bivalent Vaccine in Rabbits
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(11), P. 1698 - 1698
Published: Nov. 7, 2023
Bovine
respiratory
disease
(BRD)
is
a
global
prevalent
multifactorial
infection
primarily
caused
by
viral
and
bacterial
coinfections.
In
China,
Mycoplasma
bovis
(M.
bovis)
bovine
herpesvirus
type
1
(BoHV-1)
are
the
predominant
pathogens
associated
with
BRD.
Our
previous
study
involved
development
of
attenuated
M.
HB150
BoHV-1
gG-/tk-
vaccine
strains,
which
were
thoroughly
assessed
for
their
safety
profiles
protective
efficacy
in
cattle.
this
study,
we
applied
combination
vaccines
varying
ratios
used
rabbit
model
to
determine
efficacy.
We
PCR/RT-PCR
detect
postimmunization
challenge
shedding
BoHV-1.
Additionally,
measured
antibody
titers
expression
IFN-β
TNF-α
evaluate
humoral
cellular
immune
responses,
respectively.
Furthermore,
performed
histopathological
analysis
assess
lung
damage.
provides
evidence
effectiveness
bivalent
bovis-BoHV-1
rabbits,
particularly
when
applying
1.0
×
108
CFU
106
TCID50
strain.
The
significantly
enhanced
both
long-term
response
protection
against
challenge.
These
findings
provide
valuable
potential
application
Language: Английский
Investigation of the Optimal Immunization Dose and Protective Efficacy of an Attenuated and Marker M. bovis–Bovine Herpesvirus Type 1 Combined Vaccine in Rabbits
Sen Zhang,
No information about this author
Guoxing Liu,
No information about this author
Wenying Wu
No information about this author
et al.
Animals,
Journal Year:
2024,
Volume and Issue:
14(5), P. 748 - 748
Published: Feb. 28, 2024
Bovine
respiratory
disease
(BRD)
is
one
of
the
most
common
diseases
in
cattle
industry;
it
a
globally
prevalent
multifactorial
infection
primarily
caused
by
viral
and
bacterial
coinfections.
In
China,
Language: Английский
Development and characterization of an immortalized nasopharyngeal epithelial cell line to explore airway physiology and pathology in yak (Bos grunniens)
Jiancheng Qi,
No information about this author
Jizong Zhang,
No information about this author
Fangyuan Huang
No information about this author
et al.
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: July 17, 2024
Airway
epithelial
cells
play
a
crucial
role
in
investigating
the
physiological
and
pathological
mechanisms
of
respiratory
tract
yaks,
species
whose
unique
system
has
garnered
extensive
interest.
Despite
this
growing
interest,
there
currently
are
no
available
airway
cell
lines
from
underscoring
need
to
establish
yak
line.
Therefore,
our
objective
was
isolate
population
primary
nasopharyngeal
(pYNE)
transform
them
into
immortalized
(iYNE),
assessing
their
suitability
as
an
Language: Английский