Hydrogel Lego based on rehydrated laminate assembly for standardized production and customized integration of multifunctional hydrogel sensors DOI Creative Commons
Shuyi Wu, Xiaowei Xu, Lei Hu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Hydrogel sensors have immense potential for application in fields such as flexible wearable devices. However, hydrogel still face challenges related to process standardization, convenience of long-term storage, customization diverse scenarios, and ease multifunctional integration. In this study, a strategy the rapid rehydration prefabricated gel dry films modular assembly form multilayer devices is reported. First, developed biomass polysaccharide encapsulation composite, konjac glucomannan/sodium alginate/dopamine (KSD), was utilized encapsulate various functional materials separately then dried parts films. device, through water-triggered interlayer metal–ligand chelation bonding, personalized laminated can be assembled quickly conveniently according requirements. The binding between layers occurs formation bonds calcium ions solution carboxylic acid groups sodium alginate, which results an bond 0.57 MPa after only 1.5 min. Moreover, KSD-encapsulated anisotropic thermoplastic urethane/MXene (TPU/MXene) conductive film constructed, multilayered were by lamination film. composite accurately recognize complex deformations curved surface motion multiple signals, difficult realize ordinary sensors. bacteriostatic layer integrated on top sensing based strategy. pH-responsive membrane ZIF-8/flavanone/KSD prepared using microfluidic mosaic methods displays satisfactory biocompatibility properties. several gels customized proposed paper will enable standardized batch processing integration accordance with variety scenarios

Language: Английский

Rational design of hyper‐crosslinked polymers for biomedical applications DOI Open Access
Qian Liao, Eun Ji Kim,

Yunxin Tang

et al.

Journal of Polymer Science, Journal Year: 2023, Volume and Issue: 62(8), P. 1517 - 1535

Published: Aug. 2, 2023

Abstract Hyper‐crosslinked polymers (HCPs) are a family of that possess several desirable characteristics, including high specific surface area, excellent stability, tunable porous structures, and low‐cost reagents. As result, HCPs have gained significant attention in the areas gas storage, adsorption, catalysis, separation, carbon precursors, exhibiting advanced performances catalytic energy‐related applications. Recently, researchers explored potential biomedical engineering. In this review, we discuss classical synthesis strategies morphological assembly methods used to create with unique biological properties. We also highlight latest advances emerging HCPs, such as drug delivery, antimicrobial, bioimaging, biosensing. By providing various examples, further correlations between morphologies, enhanced properties HCPs. Finally, summarize key applications provide an outlook on research direction encourage development biomedically available Overall, offer promising new class materials for use applications, continued field will lead exciting discoveries breakthroughs.

Language: Английский

Citations

58
Curcumin-Loaded ZIF-8 Nanomaterials: Exploring Drug Loading Efficiency and Biomedical Performance DOI Creative Commons
Mahbubur Rahman,

Mohashin Kabir,

Tarikul Islam

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by rapid degradation, limited bioavailability, poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface area tunable pore size, designed used as cur delivery carrier to overcome these limitations. The synthesis of cur-loaded ZIF-8 involves solvothermal method, followed encapsulation within the porous structure ZIF-8. amount was varied synthesize series panel 0.5 mg/mL cur@ZIF-8 that showed higher drug loading efficiency (85.91 ± 1.26%) capability (12.93 0.19%) without changes in shape, crystallinity, chemical composition, thermal stability original exhibited (1591.02 m2/g) micropore volume (0.54 cm3/g). Cur@ZIF-8 demonstrated superior outstanding antibacterial achieving 99% compared free cur. It less cytotoxicity against human fibroblast cells better antioxidant properties than Furthermore, release rate under acidic conditions, which promotes wound healing due microenvironment skin. biocompatibility nanoparticles highlight their potential promising candidates for diverse applications.

Language: Английский

Citations

7
Utilization of Functionalized Metal–Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy DOI Creative Commons
Vy Anh Tran, Van Thuan Le, Van‐Dat Doan

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 931 - 931

Published: March 13, 2023

Cancer is a multifaceted disease that results from the complex interaction between genetic and environmental factors. mortal with biggest clinical, societal, economic burden. Research on better methods of detection, diagnosis, treatment cancer crucial. Recent advancements in material science have led to development metal–organic frameworks, also known as MOFs. MOFs recently been established promising adaptable delivery platforms target vehicles for therapy. These constructed fashion offers them capability drug release stimuli-responsive. This feature has potential be exploited therapy externally led. review presents an in-depth summary research conducted date field MOF-based nanoplatforms therapeutics.

Language: Английский

Citations

44
Enzyme-Responsive Zr-Based Metal–Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands DOI Creative Commons
Carolina Carrillo‐Carrión, Valentine Comaills,

Ana M. Visiga

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(23), P. 27600 - 27611

Published: May 30, 2023

We report for the first time controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, in presence of enzyme alkaline phosphatase (ALP). This unprecedented reactivity was possible thanks to prior functionalization MOF with N3-PEG-PO3 ligands, which were designed three specific aims: (1) impart colloidal stability phosphate-containing media; (2) endow multifunctionality azide groups covalent attachment an imaging agent by click-chemistry; and (3) confer stimuli-responsive properties, specifically selective doxorubicin triggered enzymatic activity ALP. Cell studies revealed that N3-(PEG)20-PO3 ligands improved their intracellular led sustained compared bare MOF. More importantly, enhanced observed cells higher expression ALP genes (HeLa versus MDA-MB-231 MCF7), confirming ALP-responsiveness system inside living cells.

Language: Английский

Citations

25
UiO-66(Zr) as drug delivery system for non-steroidal anti-inflammatory drugs DOI
Javier Salazar, Yoan Hidalgo‐Rosa, Pía C. Burboa

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 392 - 404

Published: May 5, 2024

Language: Английский

Citations

17
Advancing biomedical applications of polyoxometalate-based metal–organic frameworks: from design to therapeutic potential DOI
Lijin Wang, Pengyu Dai, Hongli Ma

et al.

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(5), P. 1339 - 1365

Published: Jan. 1, 2024

The review covers POMOF materials synthesis, modification, and unique properties, focusing on biomedical sensors therapies. Finally, the summarises challenges developments of POMOFs in biomedicine.

Language: Английский

Citations

13
Fenton chemistry activation in metal-organic frameworks for synergistic bacteria eradication DOI

Jiayi Qin,

Jia Su, Hong Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154413 - 154413

Published: July 30, 2024

Language: Английский

Citations

13
Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes DOI
Hao Wang, Mengqi Pan, Yafei Wang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(10), P. 109581 - 109581

Published: Feb. 1, 2024

Language: Английский

Citations

10
Cellulose nanocrystals as bridges to construct CNCs@ZIF-8 3D network with topological chirality for realizing efficient photocatalytic reduction of CO2 DOI
Jing Wang, Wenlei Wang,

Yao Deng

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 340, P. 126840 - 126840

Published: Feb. 19, 2024

Language: Английский

Citations

10
pH-responsive ZIF-8 film-coated mesoporous silica nanoparticles for clean, targeted delivery of fungicide and environmental hazard reduction DOI

Yingjian Ma,

Yinmin Wang, Rui Zhao

et al.

Journal of environmental chemical engineering, Journal Year: 2023, Volume and Issue: 11(6), P. 111513 - 111513

Published: Nov. 19, 2023

Language: Английский

Citations

19