Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Here,
we
show
particle
size-dependent
therapeutic
efficacy
with
a
Zn-based
metal-organic
framework
(MOF).
The
size
of
MOFs
was
tuned
in
specific
ranges
(∼100,
200,
and
300
nm)
built
upon
the
manipulation
synthetic
conditions.
X-ray
photoelectron
spectroscopy,
infrared,
PXRD,
dynamic
light
scattering
scanning
electron
microscopy
analyses
were
used
to
identify
synthesized
structures.
various
revealed
minimal
changes
molecular
properties
these
structures
regardless
their
size,
confirming
our
hypothesis
regarding
preservation
identity
MOF
nanoparticles
despite
variation.
carriers
undergo
structure
relative
destruction
response
weak
acidic
tumor
microenvironment,
this
degradation
allows
release
Nimesulide
drug
into
environment.
Interestingly,
anticancer
studies
resulting
SKBR3
(Human
breast
cancer
cell)
cells
indicate
that
different
sizes
resulted
inhibition
capacities
against
cells.
This
work
shows
importance
optimizing
geometry
carrier,
such
as
shape,
achieve
highest
cellular
uptake
performance.
Besides,
theoretical
carried
out
using
B3LYP/6-31G
(d,p)
density
functional
theory
methods
more
consider
adsorption
mechanism.
Journal of Polymer Science,
Journal Year:
2023,
Volume and Issue:
62(8), P. 1517 - 1535
Published: Aug. 2, 2023
Abstract
Hyper‐crosslinked
polymers
(HCPs)
are
a
family
of
that
possess
several
desirable
characteristics,
including
high
specific
surface
area,
excellent
stability,
tunable
porous
structures,
and
low‐cost
reagents.
As
result,
HCPs
have
gained
significant
attention
in
the
areas
gas
storage,
adsorption,
catalysis,
separation,
carbon
precursors,
exhibiting
advanced
performances
catalytic
energy‐related
applications.
Recently,
researchers
explored
potential
biomedical
engineering.
In
this
review,
we
discuss
classical
synthesis
strategies
morphological
assembly
methods
used
to
create
with
unique
biological
properties.
We
also
highlight
latest
advances
emerging
HCPs,
such
as
drug
delivery,
antimicrobial,
bioimaging,
biosensing.
By
providing
various
examples,
further
correlations
between
morphologies,
enhanced
properties
HCPs.
Finally,
summarize
key
applications
provide
an
outlook
on
research
direction
encourage
development
biomedically
available
Overall,
offer
promising
new
class
materials
for
use
applications,
continued
field
will
lead
exciting
discoveries
breakthroughs.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 931 - 931
Published: March 13, 2023
Cancer
is
a
multifaceted
disease
that
results
from
the
complex
interaction
between
genetic
and
environmental
factors.
mortal
with
biggest
clinical,
societal,
economic
burden.
Research
on
better
methods
of
detection,
diagnosis,
treatment
cancer
crucial.
Recent
advancements
in
material
science
have
led
to
development
metal–organic
frameworks,
also
known
as
MOFs.
MOFs
recently
been
established
promising
adaptable
delivery
platforms
target
vehicles
for
therapy.
These
constructed
fashion
offers
them
capability
drug
release
stimuli-responsive.
This
feature
has
potential
be
exploited
therapy
externally
led.
review
presents
an
in-depth
summary
research
conducted
date
field
MOF-based
nanoplatforms
therapeutics.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Curcumin
(cur)
possesses
excellent
therapeutic
properties,
including
anti-inflammatory,
antioxidant,
and
healing-promoting
effects.
However,
its
biomedical
application
is
impeded
by
rapid
degradation,
limited
bioavailability,
poor
aqueous
solubility.
Zeolitic
imidazole
framework
(ZIF-8),
with
a
high
surface
area
tunable
pore
size,
designed
used
as
cur
delivery
carrier
to
overcome
these
limitations.
The
synthesis
of
cur-loaded
ZIF-8
involves
solvothermal
method,
followed
encapsulation
within
the
porous
structure
ZIF-8.
amount
was
varied
synthesize
series
panel
0.5
mg/mL
cur@ZIF-8
that
showed
higher
drug
loading
efficiency
(85.91
±
1.26%)
capability
(12.93
0.19%)
without
changes
in
shape,
crystallinity,
chemical
composition,
thermal
stability
original
exhibited
(1591.02
m2/g)
micropore
volume
(0.54
cm3/g).
Cur@ZIF-8
demonstrated
superior
outstanding
antibacterial
achieving
99%
compared
free
cur.
It
less
cytotoxicity
against
human
fibroblast
cells
better
antioxidant
properties
than
Furthermore,
release
rate
under
acidic
conditions,
which
promotes
wound
healing
due
microenvironment
skin.
biocompatibility
nanoparticles
highlight
their
potential
promising
candidates
for
diverse
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(23), P. 27600 - 27611
Published: May 30, 2023
We
report
for
the
first
time
controlled
drug
release
from
a
nanoscale
Zr-based
metal-organic
framework
(MOF),
UiO-66,
in
presence
of
enzyme
alkaline
phosphatase
(ALP).
This
unprecedented
reactivity
was
possible
thanks
to
prior
functionalization
MOF
with
N3-PEG-PO3
ligands,
which
were
designed
three
specific
aims:
(1)
impart
colloidal
stability
phosphate-containing
media;
(2)
endow
multifunctionality
azide
groups
covalent
attachment
an
imaging
agent
by
click-chemistry;
and
(3)
confer
stimuli-responsive
properties,
specifically
selective
doxorubicin
triggered
enzymatic
activity
ALP.
Cell
studies
revealed
that
N3-(PEG)20-PO3
ligands
improved
their
intracellular
led
sustained
compared
bare
MOF.
More
importantly,
enhanced
observed
cells
higher
expression
ALP
genes
(HeLa
versus
MDA-MB-231
MCF7),
confirming
ALP-responsiveness
system
inside
living
cells.
Inorganic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(5), P. 1339 - 1365
Published: Jan. 1, 2024
The
review
covers
POMOF
materials
synthesis,
modification,
and
unique
properties,
focusing
on
biomedical
sensors
therapies.
Finally,
the
summarises
challenges
developments
of
POMOFs
in
biomedicine.
