Pyroptosis-Mediated Cancer Chemodynamic Therapy Driven by Multicascade Responsive Nanocatalyst DOI
Bo Hu,

Shiwen Gao,

Shaoqing Luo

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(9), P. 4333 - 4342

Published: Aug. 21, 2024

The off-target side effects and low catalytic efficiency substantially hindered the biomedical application of chemodynamic therapy (CDT). Here, we report a novel pH/GSH cascade activated core–shell nanocatalyst (MDC) to enhance cancer targeting for synergistic CDT. CaCO3 shell protects internal MnSiO3 from degradation by GSH during blood transport. In an acidic tumor microenvironment, rapid biodegradation induces CO2 production, pH increase, Ca2+ overload. Subsequently, exposed core serves as drug delivery platform with responsive Mn2+ dihydroartemisinin (DHA) release function. generated optimizes conditions, DHA acting substrate catalysis, both which promote Mn2+-mediated ROS generation. synergy overload, they collectively accelerate storm ROS, activating Caspase-1/gasdermin D mediated pyroptosis achieved remarkable inhibition. Such multicascade nanoplatform is highly instructive further metal nanocatalysts therapies.

Language: Английский

Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy DOI

Lianyi Yang,

Yazhen Wang, Yujun Song

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 354 - 366

Published: May 3, 2024

Language: Английский

Citations

12
MOF-derived bundle-like Mn doped NiO with rich oxygen vacancy as oxidase mimic for the determination of total antioxidant capacity DOI
Yin He, Min Feng, Xiaodan Zhang

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137227 - 137227

Published: Jan. 1, 2025

Language: Английский

Citations

1
Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment DOI
Yutang Li, Yandong Wang, Zhao Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

Citations

7
Photothermal amplified multizyme activity for synergistic photothermal-catalytic tumor therapy DOI
Zhichao Hu, Xue Zhou, Wei Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 375 - 383

Published: Sept. 28, 2024

Language: Английский

Citations

7
The Tripartite Cascade Strategy Amplifies Cellular Oxidative Stress to Disrupt Oxidation–Reduction Homeostasis for Tumor Immunogenic Cell Death DOI
Lingdong Jiang, Xiao‐Jia Chen, Yueqing Gu

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 730 - 740

Published: Jan. 27, 2025

Language: Английский

Citations

0
A hyaluronic acid-based dual-functional hydrogel microneedle system for sequential melanoma ablation and skin regeneration DOI

Zixuan Zhang,

Zhuo Zhang, Wen Zeng

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138039 - 138039

Published: Nov. 1, 2024

Language: Английский

Citations

3
Chemodynamic PtMn Nanocubes for Effective Photothermal ROS Storm a Key Anti-Tumor Therapy in-vivo DOI Creative Commons
Chen Wang, Hongmei Zhou,

Mekhrdod Kurboniyon

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5045 - 5056

Published: May 1, 2024

Background: Chemodynamic therapy (CDT) is a new treatment approach that triggered by endogenous stimuli in specific intracellular conditions for generating hydroxyl radicals. However, the efficiency of CDT severely limited Fenton reaction agents and harsh conditions. Methods: Bimetallic PtMn nanocubes were rationally designed simply synthesized through one-step high-temperature pyrolysis process controlling both nucleation subsequent crystal growth stage. The polyethylene glycol was modified to enhance biocompatibility. Results: Benefiting from alloying Pt with Mn doping, structure electron cloud has changed, resulting different degrees shift binding energy, increasing activity. could catalyze hydrogen peroxide toxic radicals mild acid. Meanwhile, intrinsic glutathione (GSH) depletion activity consumed GSH assistance 3+ /Mn 2+ . Upon 808 nm laser irradiation, temperature due surface plasmon resonance effect metal can also reaction. Conclusion: not only destroy antioxidant system via efficient reactive oxygen species generation continuous consumption but propose photothermal noble enhanced Keywords: metal, Mn-doping, reaction, effect, chemodynamic

Language: Английский

Citations

2
CuNCs-Based pH-Responsive Degradable Nanoplatform for Enhanced CDT/IIT Synergistic Tumor Therapy in a “One-Stone-Two-Birds” Manner DOI

Yao‐Jia Ma,

Zheng‐Chen Su,

Fang-Qi Wang

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2515 - 2525

Published: May 23, 2024

Tumor-associated macrophages (TAMs) account for 30%–50% of tumor tissue and are involved in tumorigenesis, progression, invasion, metastasis. Thus, cells no longer the only target therapy. Here, we proposed a strategy "one-stone-two-birds" by targeting M2 TAMs simultaneously with ion interference therapy (IIT) synergistic chemodynamic (CDT) via nanoplatform (CZPM). The CZPM was prepared employing CuNCs as source light Fenton metal, encapsulated ZIF-8 IIT, finally modified mannose. obtained could enhance cellular uptake CT26 respond to cleavage acidic environment endosomes lysosomes, releasing Zn2+ IIT synergistically enhancing CDT. In vitro vivo experiments confirmed that showed significant therapeutic effects. conclusion, an effective dual-targeting dual-therapeutic has been developed based on nanoplatform.

Language: Английский

Citations

1
Pyroptosis-Mediated Cancer Chemodynamic Therapy Driven by Multicascade Responsive Nanocatalyst DOI
Bo Hu,

Shiwen Gao,

Shaoqing Luo

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(9), P. 4333 - 4342

Published: Aug. 21, 2024

The off-target side effects and low catalytic efficiency substantially hindered the biomedical application of chemodynamic therapy (CDT). Here, we report a novel pH/GSH cascade activated core–shell nanocatalyst (MDC) to enhance cancer targeting for synergistic CDT. CaCO3 shell protects internal MnSiO3 from degradation by GSH during blood transport. In an acidic tumor microenvironment, rapid biodegradation induces CO2 production, pH increase, Ca2+ overload. Subsequently, exposed core serves as drug delivery platform with responsive Mn2+ dihydroartemisinin (DHA) release function. generated optimizes conditions, DHA acting substrate catalysis, both which promote Mn2+-mediated ROS generation. synergy overload, they collectively accelerate storm ROS, activating Caspase-1/gasdermin D mediated pyroptosis achieved remarkable inhibition. Such multicascade nanoplatform is highly instructive further metal nanocatalysts therapies.

Language: Английский

Citations

0