Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment DOI
Dongqi Sun, Xinxin Sun, Xuan Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

Citations

15
Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer DOI

Junhao Gu,

Danling Cheng,

Haiyan Li

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(25), P. 6091 - 6101

Published: Jan. 1, 2024

Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis treatment remain a great challenge. The simultaneous inhibition tumor growth is necessary for cancer obtain ideal therapeutic outcomes. We herein report development radioactive hybrid semiconducting polymer nanoparticles (SPNH) imaging-guided tri-modal therapy cancer. Two polymers are used form SPNH with diameter around 60 nm via nano-coprecipitation they also labeled iodine-131 (131I) enhance imaging functions. formed show good radiolabeling stability excellent photodynamic photothermal effects under 808 laser irradiation produce singlet oxygen (1O2) heat. Moreover, can generate 1O2 ultrasound their sonodynamic properties. After intravenous tail vein injection, effectively accumulate in subcutaneous 4T1 tumors living mice as verified fluorescence single photon emission computed tomography (SPECT) imaging. With using an US, mediate (PDT), (PTT) (SDT) kill cells. Such leads improved efficacy inhibiting suppressing compared sole SDT combinational PDT-PTT. This study thus demonstrates applications diagnose combine different therapies effective treatment.

Language: Английский

Citations

4
Exceptional Second Near-Infrared Window Organic Photothermal Material for High-Temperature Applications Activated by a 1064 nm Laser DOI

Huaxin Yang,

Weifang Wang, Ping Deng

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1060 - 1069

Published: Feb. 17, 2025

Language: Английский

Citations

0
Enhanced Delivery of Photothermal Gelatin Nanoparticle for Redox Balanced Nanocatalytic Tumor Chemotherapy DOI
Jiayi Hu,

Xiaoyu Jia,

Manlin Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Nanocatalytic platforms are promising in cancer therapeutics via combining multiple treatments, which can be leveraged through the metabolic dysfunction progression. However, lack of effective tumor delivery hampers this approach. Here, a gelatin‐based platform is designed that preloaded with gold nanoparticles and photothermal polypyrrole (GNPs@AuNPs‐PPy) an acid‐induced doping enhancement. Benefiting from associated overexpression H 2 O , peroxidase‐like Au induce burst oxidative reactive oxygen species local microenvironment (TME). Subsequent orchestration redox surroundings recruits immune cells, showcasing antineoplastic pathway. Under near infrared light (NIR) irradiation, nanohybrids exhibit dual pH/NIR enhanced drug release within TME, while allowing for multimodal imaging‐guided theranostics. Leveraging modality, GNPs@AuNPs‐PPy delivers quercetin (a natural antitumor mediator) boosting anti‐tumor therapy. The gelatin‐mediated nanomedicine provides alternative combinatorial dynamic treatment.

Language: Английский

Citations

0
Development of a Highly Efficient NIR-II Phototherapeutic Agent for Fluorescence Imaging-Guided Synergistic PTT/PDT/Chemotherapy of Colorectal Cancer DOI
Ji Liu, Lei Liang,

Ping Gan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

NIR-II-triggered phototherapy presents a noninvasive, resistance-free alternative therapeutic approach with deeper tissue penetration and improved imaging of deep tumors. However, many NIR-II phototherapeutic agents suffer from low fluorescence quantum yields, poor photothermal conversion efficiency (PCE), reduced efficacy due to the upregulation heat shock protein HSP70. This study develops small-molecule agent (IRF) high yield (17.4%), excellent PCE (96.8%) for therapy (PTT), photodynamic (PDT) activity. To decrease thermal resistance during phototherapy, IRF evodiamine (EVO) were loaded onto hyaluronic acid (HA)-modified nanoparticles, creating multifunctional nanoplatform termed EVO/IRF@HA NPs. NPs can actively target tumors via HA moiety. Upon 980 nm laser irradiation, increases temperature content reactive oxygen species synergistic PTT/PDT. Importantly, EVO effectively inhibits overexpression HSP70, enabling combined PTT/PDT/chemotherapy effective colorectal cancer (CRC) treatment.

Language: Английский

Citations

0
Enhanced sequential osteosarcoma therapy using a 3D-Printed bioceramic scaffold combined with 2D nanosheets via NIR-II photothermal-chemodynamic synergy DOI
Guangyu Jian, Si Wang, Xinlu Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 540 - 555

Published: May 1, 2025

Language: Английский

Citations

0
Hyaluronic acid-targeted dual-bubble/photothermal-driven nanomissile for enhanced “four-in-one” anti-tumor strategy DOI
Feng Ouyang, Yu Liu, L. Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133997 - 133997

Published: July 29, 2024

Language: Английский

Citations

3
From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies DOI Creative Commons
Dongyue Xie,

Linglin Sun,

Manxiang Wu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, iron-based organic frameworks (MOFs) display versatility for imaging therapy improvement. In terms of imaging, improve the sensitivity accuracy techniques resonance (MRI) photoacoustic (PAI) support development multimodal platforms. Regarding treatment, play a key role advanced strategies immunotherapy, hyperthermia, synergistic combination therapy, which effectively overcome tumor-induced drug resistance reduce systemic toxicity. The integration with artificial intelligence (AI) radiomics further expands its capabilities precise identification, treatment optimization, amplifies monitoring. now link materials science computing clinical innovations enable next-generation cancer diagnostics therapeutics.

Language: Английский

Citations

0
Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment DOI
Huimin Li, Pengju Li, Jiarui Zhang

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

Citations

0
Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Citations

0