Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7486 - 7502

Published: May 9, 2022

Hypoxia, excessive reactive oxygen species (ROS), impaired angiogenesis, lasting inflammation, and bacterial infection, are key problems impeding diabetic wound healing. Particularly, controllable release ROS scavenging capacities critical during the healing process. Here, an injectable hydrogel based on hyaluronic acid-graft-dopamine (HA-DA) polydopamine (PDA) coated Ti3C2 MXene nanosheets is developed catalytically cross-linked by oxyhemoglobin/hydrogen (HbO2/H2O2) system combined with mild photothermal stimulation for HbO2 not only acts as a horseradish peroxidase-like to catalyze formation but also carrier controllably when activated heat produced from near-infrared (NIR) irradiation. Specifically, can provide repeatedly binding in air NIR off. The stable photoresponsive heating behavior of ensures repeatable release. Additionally, artificial nonenzymatic antioxidant proposed scavenge nitrogen including H2O2, O2•-, •OH, keeping intracellular redox homeostasis alleviating oxidative stress, eradicate bacteria avoid infection. antibacterial abilities further improved PDA coating, which promotes cross-linking into network hydrogel. HA-DA molecules endow capacity regulate macrophage polarization M1 M2 achieve anti-inflammation. More importantly, MXene-anchored multifunctions tissue adhesion, self-healing, injectability, hemostasis, stimulation, greatly human umbilical vein endothelial cell proliferation migration notably facilitates infected

Language: Английский

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Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 20, P. 561 - 573

Published: July 1, 2022

Neovascularization is critical to improve the diabetic microenvironment, deliver abundant nutrients wound and promote closure. However, excess of oxidative stress impedes healing process. Herein, a self-adaptive multifunctional hydrogel with self-healing property injectability fabricated through boronic ester-based reaction between phenylboronic acid groups 3-carboxyl-4-fluorophenylboronic -grafted quaternized chitosan hydroxyl polyvinyl alcohol, in which pro-angiogenic drug desferrioxamine (DFO) loaded form gelatin microspheres (DFO@G). The ester bonds can self-adaptively react hyperglycemic hydrogen peroxide alleviate release DFO@G early phase healing. A sustained DFO then realized by responding overexpressed matrix metalloproteinases. In full-thickness model, accelerates angiogenesis upregulating expression hypoxia-inducible factor-1 angiogenic growth factors, resulting collagen deposition rapid This not only change microenvironment pro-healing state decreasing stress, but also respond metalloproteinases DFO. has potential for treating wounds.

Language: Английский

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Multifunctional Magnesium Organic Framework-Based Microneedle Patch for Accelerating Diabetic Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 17842 - 17853

Published: Nov. 11, 2021

Diabetic wound healing is one of the major challenges in biomedical fields. The conventional single drug treatments have unsatisfactory efficacy, and delivery effectiveness restricted by penetration depth. Herein, we develop a magnesium organic framework-based microneedle patch (denoted as MN-MOF-GO-Ag) that can realize transdermal combination therapy for diabetic healing. Multifunctional frameworks (Mg-MOFs) are mixed with poly(γ-glutamic acid) (γ-PGA) hydrogel loaded into tips MN-MOF-GO-Ag, which slowly releases Mg2+ gallic acid deep layer dermis. released induces cell migration endothelial tubulogenesis, while acid, reactive oxygen species-scavenger, promotes antioxidation. Besides, backing MN-MOF-GO-Ag made γ-PGA graphene oxide-silver nanocomposites (GO-Ag) further enables excellent antibacterial effects accelerating therapeutic on demonstrated full-thickness cutaneous wounds mouse model. significant improvement achieved mice treated MN-MOF-GO-Ag.

Language: Английский

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Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(12)

Published: May 3, 2021

An infected skin wound caused by external injury remains a serious challenge in clinical practice. Wound dressings with the properties of antibacterial activity and potent regeneration capacity are highly desirable for healing. In this paper, degradable, ductile, wound-friendly Zn-MOF encapsulated methacrylated hyaluronic acid (MeHA) microneedles (MNs) array is fabricated through molding method promoting Due to damage capability against bacteria capsule oxidative stress zinc ion released from Zn-MOF, such MNs presents excellent activity, as well considerable biocompatibility. Besides, degradable composed photo-crosslinked MeHA possesses superior capabilities continuously steadily release loaded active ingredients avoid secondary wound. Moreover, low molecular weight (HA) generated hydrolysis also conducive tissue regeneration. Benefiting these features, it has been demonstrated that can dramatically accelerate epithelial neovascularization. These results indicate combination MOFs great value

Language: Английский

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Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing

Advanced Science, Journal Year: 2022, Volume and Issue: 9(13)

Published: March 10, 2022

Abstract Wound dressing with the capacities of antioxidation, antiinflammation, and efficient angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel core‐shell hyaluronic acid (HA) microneedle (MN) patch ferrum‐mesenchymal stem cell‐derived artificial nanovesicles (Fe‐MSC‐NVs) polydopamine nanoparticles (PDA NPs) encapsulated in needle tips presented Fe‐MSC‐NVs containing multifunctional therapeutic cytokines are inner HA core MN accelerating angiogenesis. The PDA NPs outer methacrylated (HAMA) shell to overcome adverse impacts from reactive oxygen species (ROS)‐derived oxidative stress. With gradual degradation HAMA skin, sustainably released at lesion suppress ROS‐induced inflammation reaction, while significantly increase migration, proliferation, tube formation human umbilical vein endothelial cells (HUVEC). More attractively, combination further promotes M2 macrophage polarization, thereby suppressing inflammation. Through vivo experiment, Fe‐MSC‐NVs/PDA shows an excellent effect diabetic These features pro‐angiogenesis indicate proposed composite valuable clinical healing applications.

Language: Английский

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Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(49)

Published: Oct. 30, 2020

Nanomaterial-based enzyme-mimetic catalysts (Enz-Cats) have received considerable attention because of their optimized and enhanced catalytic performances selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to molecular/atomic-level centers, high porosity, large surface area, loading capacity, homogeneous structure, metal–organic frameworks (MOFs) emerged as one the most promising materials engineering Enz-Cats. Here, recent advances design MOF-engineered Enz-Cats, including preparation methods, composite constructions, structural characterizations, biomedical applications, are highlighted commented upon. In particular, performance, selectivities, essential mechanisms, potential structure–property relations these Enz-Cats accelerating reactions discussed. Some applications also breifly proposed. These include, for example, tumor therapies, bacterial disinfection, tissue regeneration, biosensors. Finally, future opportunities challenges emerging research frontiers thoroughly Thereby, pathways perspectives designing state-of-the-art sciences offered.

Language: Английский

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Multiple Stimuli‐Responsive MXene‐Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Small, Journal Year: 2021, Volume and Issue: 18(5)

Published: Nov. 25, 2021

Chronic wound healing is an important and basic issue in medical healthcare fields. Recently, stimuli-responsive hydrogel systems have emerged as promising drug delivery carriers for management. However, given to the limited therapeutic outcomes, new efficient treatment are urgently needed. Here, development of a 2D MXene-based system highly photo- magnetic-responsive oriented deep chronic wounds repair presented. The intelligent responsive composed MXene-wrapped magnetic colloids poly(N-isopropyl acrylamide)-alginate dual-network hydrogels. It demonstrated that exhibits multiple response capability controllable ability, which can reduce toxic side effects drugs promote process well. Notably, practical performance by applying it full-thickness cutaneous subcutaneous infected rat model, indicates great prospect clinical other related biomedical

Language: Английский

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Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Language: Английский

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<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 9717 - 9743

Published: Dec. 1, 2020

Abstract: Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments nanoparticles/hydrogels nanotechnology used for promoting the process either diabetic animal models or diabetes mellitus. These promote by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) non-bioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method many types components) are currently favored researchers. In addition, can be combined some technology (including PTT, LBL self-assembly technique 3D-printing technology) treat repair. By reviewing recent literatures, we also proposed new strategies improving multifunctional treatment wounds future. Keywords: hydrogels, nanoparticles, nanotechnology,

Language: Английский

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