Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Language: Английский

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Engineering Bacteria‐Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(48)

Published: Sept. 1, 2021

Abstract Engineering therapeutic angiogenesis in impaired tissues is critical for chronic wound healing. Materials can be engineered to deliver specific biological cues that enhance angiogenesis. However, currently available materials have limitations use engineering since the complex inflammation environment of wounds requires spatiotemporal control. Immune cells are central component microenvironment and orchestrate immune responses This study presents a novel approach using delivery system comprising living Lactococcus , incorporated heparin‐poloxamer thermoresponsive hydrogel, designed bioengineer highly dynamic‐temporal manner. The produce protect vascular endothelial growth factor (VEGF) increase proliferation, migration, tube formation cells, as well secrete lactic acid shift macrophages toward an anti‐inflammatory phenotype, resulting successful diabetic wounds. Further, confines bacterial population wounds, thereby minimizing risk systemic toxicities. Therefore, this hydrogel harnessed safe efficient therapeutics drive rapid healing may serve promising scaffold regenerative medicine.

Language: Английский

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Recent advances in responsive hydrogels for diabetic wound healing

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100508 - 100508

Published: Nov. 30, 2022

Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.

Language: Английский

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Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 426, P. 130634 - 130634

Published: June 6, 2021

Diabetic wounds represent a pressing concern affecting the health and quality of life patients. Despite continuous improvement in therapeutic strategy, diabetic remain worldwide challenge. Vascular dysfunction, part due to hyperglycemia, is well-identified factor contributing inadequate healing wounds. In current study, we utilize an extrusion-based cryogenic 3D printing technology construct decellularized small intestinal submucosa (SIS) combined with mesoporous bioactive glass (MBG) exosomes fabricate produce scaffold dressing (SIS/[email protected]) which permits sustained release exosomes. The SIS/[email protected] hydrogel scaffolds possess good structure suitable porosity, biocompatibility hemostasis ability, could promote proliferation, migration angiogenesis Human umbilical vein endothelial cells (HUVECs). results vivo indicate that accelerate wound through increasing blood flow stimulating process wound. also granulation tissue formation, well-organized collagen fiber deposition, functional new vessel growth, factors promoting healing. Taken together, this research presents promising novel strategy for treatment

Language: Английский

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Nanoparticle-based therapeutic approaches for wound healing: a review of the state-of-the-art

Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 27, P. 101319 - 101319

Published: Dec. 21, 2022

Language: Английский

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Adipose‐Derived Mesenchymal Stem Cell‐Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(30)

Published: Sept. 15, 2023

Wound healing is an urgent clinical challenge, particularly in the case of chronic wounds. Traditional approaches to wound have limited therapeutic efficacy due lengthy times, risk immune rejection, and susceptibility infection. Recently, adipose-derived mesenchymal stem cell-derived exosomes (ADSC-exos) emerged as a promising modality for tissue regeneration repair. In this study, development novel extracellular matrix hydrogel@exosomes (ECM@exo) reported, which entails incorporation ADSC-exos into hydrogel (ECM hydrogel). This solution forms at physiological temperature (≈37 °C) upon local injection site. ECM@exo enables sustained release from ECM hydrogel, maintains high concentrations The displays good biocompatibility biodegradability. vivo vitro results demonstrate that treatment effectively reduces inflammation promotes angiogenesis, collagen deposition, cell proliferation, migration, thereby accelerating process. Overall, innovative approach offers new avenue via biological with controlled exosome release.

Language: Английский

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Diabetes immunity-modulated multifunctional hydrogel with cascade enzyme catalytic activity for bacterial wound treatment

Biomaterials, Journal Year: 2022, Volume and Issue: 289, P. 121790 - 121790

Published: Sept. 5, 2022

Language: Английский

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Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission

Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 323 - 336

Published: March 15, 2023

Chronic diabetic wounds remain a globally recognized clinical challenge. They occur due to high concentrations of reactive oxygen species and vascular function disorders. A promising strategy for wound healing is the delivery exosomes, comprising bioactive dressings. Metformin activates endothelial growth factor pathway, thereby improving angiogenesis in hyperglycemic states. However, multifunctional hydrogels loaded with drugs substances synergistically promote repair has been rarely reported, mechanism their combinatorial effect exosome metformin remains unclear. Here, we engineered dual-loaded possessing tissue adhesive, antioxidant, self-healing electrical conductivity properties, wherein 4-armed SH-PEG cross-links Ag+, which minimizes damage goods investigated promotion repair. Multiwalled carbon nanotubes exhibiting good were also incorporated into generate hydrogen bonds thiol group, creating stable three-dimensional structure loading. The model present study suggests that PEG/Ag/CNT-M + E hydrogel promotes by triggering cell proliferation relieving peritraumatic inflammation injury. involves reducing level interfering mitochondrial fission, protecting F-actin homeostasis alleviating microvascular dysfunction. Hence, propose drug-bioactive substance combination therapy provide potential developing function-associated strategies treating chronic wounds.

Language: Английский

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Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 330 - 345

Published: Feb. 14, 2024

The management of chronic wounds in diabetes remains challenging due to the complexity impaired wound healing, delayed susceptibility infection, and elevated risk reopening, highlighting need for effective with innovative approaches such as multifunctional hydrogels. Here, we have produced HA-DA@rhCol hydrogels consisting dopamine-modified hyaluronic acid recombinant human collagen type-III (rhCol) by oxidative coupling catechol group using H

Language: Английский

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Multifunctional Hyaluronic Acid Microneedle Patch Embedded by Cerium/Zinc‐Based Composites for Accelerating Diabetes Wound Healing

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(24)

Published: April 22, 2023

Chronic nonhealing diabetic wounds are becoming increasingly severe, with high rates of mortality and disability, owing to the difficulty in wound healing caused by hyperglycemia, blocked angiogenesis, biofilm infection, excessive oxidative stress. A multicomponent enzyme-responsive natural polymer, a hyaluronic acid (HA) microneedle, embedded cerium/zinc-based nanomaterial (ZCO) for treatment is reported. ZCO-HA can destroy oxidation balance bacteria, kill scavenge reactive oxygen species (ROS) alleviate stress via adjustable release Zn2+ Ce3+ /4+ . Additionally, exhibits good anti-inflammatory activity through nuclear factor kappa-B (NF-κB) pathway, which reduces inflammatory state macrophages promotes cell proliferation, migration, angiogenesis. In vitro experiments shows that accompanies mouse fibroblast promoting human umbilical vein endothelial tube formation. vivo studies mice streptozotocin-induced (STZ)-induced diabetes reveal this microneedle accelerates without systemic toxicity. RNA transcriptome sequencing illustrates HA migration inhibits reactions damage NF-κB signaling pathway.

Language: Английский

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