Thermal Atomization of Platinum Nanoparticles into Single Atoms: An Effective Strategy for Engineering High-Performance Nanozymes

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(44), P. 18643 - 18651

Published: Nov. 2, 2021

Although great progress has been made in artificial enzyme engineering, their catalytic performance is far from satisfactory as alternatives of natural enzymes. Here, we report a novel and efficient strategy to access high-performance nanozymes via direct atomization platinum nanoparticles (Pt NPs) into single atoms by reversing the thermal sintering process. Atomization Pt NPs makes metal sites fully exposed results engineerable structural electronic properties, thereby leading dramatically enhanced enzymatic performance. As expected, as-prepared thermally stable single-atom nanozyme (PtTS-SAzyme) exhibited remarkable peroxidase-like activity kinetics, exceeding nanoparticle nanozyme. The following density functional theory calculations revealed that engineered P S not only promote process PtTS-SAzyme but also endow with unique structure owing electron donation atoms, well acceptance N which simultaneously contribute substantial enhancement enzyme-like PtTS-SAzyme. This work demonstrates nanoparticle-based an effective for engineering nanozymes, opens up new way rationally design optimize enzymes mimic

Language: Английский

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Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Feb. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Language: Английский

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Porous organic polymers as a platform for sensing applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 2031 - 2080

Published: Jan. 1, 2022

Sensing analysis is significantly important for human health and environmental safety. In this review, POPs used as platforms various sensing applications have been summarized discussed.

Language: Английский

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Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(50)

Published: Sept. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Language: Английский

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Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 22, 2023

Nanozymes have great potential to be used as an alternative natural enzymes in a variety of fields. However, low catalytic activity compared with limits their practical use. It is still challenging design nanozymes comparable counterparts terms the specific activity. In this study, surface engineering strategy employed improve Ru using charge-transferrable ligands such polystyrene sulfonate (PSS). PSS-modified nanozyme exhibits peroxidase-like up 2820 U mg

Language: Английский

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Porous organic polymers (POPs) for environmental remediation

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(10), P. 4083 - 4138

Published: Jan. 1, 2023

Porous organic polymers show great potential for addressing environmental pollution challenges, including chemical sensing, wastewater treatment, toxic gas sorption, heterogeneous catalysis, and further promoting sustainable remediation strategies.

Language: Английский

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Coexistence of Fe Nanoclusters Boosting Fe Single Atoms to Generate Singlet Oxygen for Efficient Aerobic Oxidation of Primary Amines to Imines

ACS Catalysis, Journal Year: 2022, Volume and Issue: 12(9), P. 5595 - 5604

Published: April 26, 2022

Tuning the geometric and electronic structure of single-metal-atom catalysts via simultaneous presence metal nanoparticles or nanoclusters (NCs) offers an alternative avenue to improving their catalytic performance. Herein, we demonstrate that coexistence Fe NCs in proximity single atoms on N-doped porous carbon can significantly improve performance aerobic oxidation primary amines imines using air as oxidant. A broad spectrum aromatic, heterocyclic, aliphatic was efficiently selectively oxidized into corresponding good high yields. Experimental measurements theoretical calculations reveal interacts with atoms, which not only benefits adsorption molecular O2 amine substrates but also promotes activation generate singlet oxygen (1O2) then facilitates key intermediate imine formation H-atom abstraction a lower energy barrier, thereby boosting reaction activity.

Language: Английский

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Advanced Strategies for Stabilizing Single-Atom Catalysts for Energy Storage and Conversion

Electrochemical Energy Reviews, Journal Year: 2022, Volume and Issue: 5(3)

Published: Sept. 1, 2022

Well-defined atomically dispersed metal catalysts (or single-atom catalysts) have been widely studied to fundamentally understand their catalytic mechanisms, improve the efficiency, increase abundance of active components, enhance catalyst utilization, and develop cost-effective effectively reduce usage noble metals. Such relatively higher selectivity activity with maximum atom utilization due unique characteristics high dispersion a low-coordination environment. However, freestanding single atoms are thermodynamically unstable, such that during synthesis reactions, they inevitably tend agglomerate system energy associated large surface areas. Therefore, developing innovative strategies stabilize catalysts, including mass-separated soft landing, one-pot pyrolysis, co-precipitation, impregnation, atomic layer deposition, organometallic complexation, is critically needed. Many types supporting materials, polymers, commonly used in these fabrication techniques. Herein, we review stabilization catalyst, different methods, specific metals carriers, advantages disadvantages. In particular, this focuses on application polymers functions as carriers for atoms, synthetic templates, encapsulation agents, protection agents process. The technical challenges currently faced by summarized, perspectives related future research directions enhancement loading content, large-scale implementation proposed realize practical applications. Single-atom characterized dispersibility, weak coordination environments, selectivity, highest utilization. free area, individual usually unstable prone agglomeration reactions. researchers developed strategies, sedimentation, coprecipitation, step reduction, precipitation, This article summarizes from aspects support types, reaction its focus preparation role manufacturing main feature polymer-derived materials contain abundant heteroatoms, N, possess lone-pair electrons. These electrons can anchor through strong interactions. environment facilitate formation because enlarge average distance precursor adsorbed polymer matrix. Polymers nitrogen groups favorable candidates dispersing weakening tendency aggregation redistributing charge densities around performance. provides summary analysis current directions, mechanism sufficiently loading, implementation.

Language: Английский

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Green Synthesis of Magnesium Oxide Nanoparticles and Nanocomposites for Photocatalytic Antimicrobial, Antibiofilm and Antifungal Applications

Catalysts, Journal Year: 2023, Volume and Issue: 13(4), P. 642 - 642

Published: March 23, 2023

Magnesium oxide nanoparticles (MgO NPs) have emerged as potential materials for various biomedical applications due to their unique physicochemical properties, including biodegradability, biocompatibility, cationic capacity, high stability and redox properties. MgO NPs become an attractive platform combat microbes may be a promising alternative overcome challenges associated with eliminating microbial biofilms antibiotic resistance. Hence, the increasing use of in biomedicine, new synthetic strategies are necessary. synthesised using green methods non-toxic, eco-friendly wide range biological, medical catalytic applications. This review presents recent advances biosynthesis by diverse bio-templates, such plant, bacterial, fungal algal extracts. Its photocatalytic properties show suitable inhibitory function against pathogenic agents, proliferation, biofilm formation growth. Furthermore, relevant nanocomposites comprehensively discussed regarding mechanisms effect on microbes, strains, well future perspectives.

Language: Английский

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Nanozymes for Regenerative Medicine

Small Methods, Journal Year: 2022, Volume and Issue: 6(11)

Published: Oct. 6, 2022

Abstract Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following kinetics. Compared natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, magnetic, fluorescent, electrical properties nanomaterials, making them promising replacements for enzymes in industrial, biological, medical fields. On account rapid development recently, their application potentials regeneration medicine are gradually being explored. To highlight achievements field, this review summarizes catalytic mechanism four types representative nanozymes. Then, strategies improve biocompatibility discussed. covers recent advances tissue including wound healing, nerve defect repair, bone regeneration, cardiovascular disease treatment. In addition, challenges prospects nanozyme researches summarized.

Language: Английский

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