MXene: A wonderful nanomaterial in antibacterial DOI Creative Commons

Surong Ye,

Huichao Zhang,

Huiyan Lai

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 1, 2024

Increasing bacterial infections and growing resistance to available drugs pose a serious threat human health the environment. Although antibiotics are crucial in fighting infections, their excessive use not only weakens our immune system but also contributes resistance. These negative effects have caused doctors be troubled by clinical application of antibiotics. Facing this challenge, it is urgent explore new antibacterial strategy. MXene has been extensively reported tumor therapy biosensors due its wonderful performance. Due large specific surface area, remarkable chemical stability, hydrophilicity, wide interlayer spacing, excellent adsorption reduction ability, shown potential for biopharmaceutical applications. However, there few antimicrobial evaluations on MXene. The current mechanisms mainly include physical damage, induced oxidative stress, photothermal photodynamic therapy. In paper, we reviewed MXene-based composites discussed guide further research field.

Language: Английский

3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models DOI
Ran Nie, Yue Sun, Huixin Lv

et al.

Nanoscale, Journal Year: 2022, Volume and Issue: 14(22), P. 8112 - 8129

Published: Jan. 1, 2022

The repair of infected bone defects with irregular shapes is still a challenge in clinical work. Infected are faced several major concerns: the complex defects, intractable bacterial infection and insufficient osseointegration. To solve these problems, we developed personalized MXene composite hydrogel scaffold GelMA/β-TCP/sodium alginate (Sr2+)/MXene (Ti3C2) (GTAM) photothermal antibacterial osteogenic abilities by 3D printing. In vitro, GTAM scaffolds could kill both Gram-positive Gram-negative bacteria NIR irradiation due to excellent effects MXene. Furthermore, rat marrow mesenchymal stem cells were mixed into bioinks for bioprinting. cell-laden printed showed biocompatibility formation ability depending on MXene, crosslinked Sr2+, β-TCP. vivo, implanted S. aureus-infected mandible rats irradiation. accelerate healing regeneration, play synergistic roles effects. This study not only provides strategy precise osteogenesis but also broadens biomedical applications materials.

Language: Английский

Citations

111
Size-dependent photothermal antibacterial activity of Ti C T MXene nanosheets against methicillin-resistant Staphylococcus aureus DOI
Yujie Gao, Yuanhao Dong, Shuting Yang

et al.

Journal of Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 617, P. 533 - 541

Published: March 9, 2022

Language: Английский

Citations

105
Aggregation-Induced Emission Nanoparticles for Single Near-Infrared Light-Triggered Photodynamic and Photothermal Antibacterial Therapy DOI
Wentao Wang, Fan Wu, Qicheng Zhang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7961 - 7970

Published: May 3, 2022

Phototheranostics is a potential area for precision medicine, which has received increasing attention antibacterial applications. Integrating all phototheranostic modalities in single molecule and achieving precise spatial colocalization challenging task because of the complexity energy dissipation molecular design. Here, type quaternary amine functionalized aggregation-induced emission (AIE), AIEgen, was synthesized used to produce singlet oxygen (1O2) heat, were eradicate bacteria. With introduction positive charge AIE nanoparticles (AIE NPs) could selectively target Notably, NPs displayed obvious performance against Gram-positive bacteria (Staphylococcus aureus) Gram-negative (Escherichia coli). The rates as high 99.9% 99.8% S. aureus E. coli, respectively. Therefore, our results suggested acting broad-spectrum antimicrobial materials, provided strategy treating different microorganisms.

Language: Английский

Citations

104
Roles of MXenes in biomedical applications: recent developments and prospects DOI Creative Commons
Hui Li, Rangrang Fan, Bingwen Zou

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 2, 2023

Abstract ....With the development of nanomedical technology, application various novel nanomaterials in biomedical field has been greatly developed recent years. MXenes, which are new inorganic with ultrathin atomic thickness, consist layered transition metal carbides and nitrides or carbonitrides have general structural formula M n+1 X n T x (n = 1–3). Based on unique features such as thickness high specific surface area, their excellent physicochemical properties, photothermal conversion efficiency antibacterial MXenes widely applied field. This review systematically summarizes MXene-based materials biomedicine. The first section is a brief summary synthesis methods modification strategies, followed by focused overview analysis applications biosensors, diagnosis, therapy, agents, implants, among other areas. We also two popular research areas: wearable devices immunotherapy. Finally, difficulties progress clinical translation briefly discussed. Graphical

Language: Английский

Citations

102
Recent advances in niobium MXenes: Synthesis, properties, and emerging applications DOI Creative Commons
P. Abdul Rasheed, Ravi P. Pandey, Fawzi Banat

et al.

Matter, Journal Year: 2022, Volume and Issue: 5(2), P. 546 - 572

Published: Feb. 1, 2022

Language: Английский

Citations

80
Wound management materials and technologies from bench to bedside and beyond DOI
Canran Wang, Ehsan Shirzaei Sani, Chia-Ding Shih

et al.

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(8), P. 550 - 566

Published: June 17, 2024

Language: Английский

Citations

79
Nanomaterial-Based Antimicrobial Coating for Biomedical Implants: New Age Solution for Biofilm-Associated Infections DOI Creative Commons
Jyotirmayee Sahoo,

Sanchita Sarkhel,

Nivedita Mukherjee

et al.

ACS Omega, Journal Year: 2022, Volume and Issue: 7(50), P. 45962 - 45980

Published: Dec. 10, 2022

Recently, the upsurge in hospital-acquired diseases has put global health at risk. Biomedical implants being primary source of contamination, development biomedical with antimicrobial coatings attracted attention a large group researchers from around globe. Bacteria develops biofilms on surface implants, making it challenging to eradicate them standard approach administering antibiotics. A further issue current concern is fast resurgence resistance conventional As nanotechnology continues advance, various types nanomaterials have been created, including 2D nanoparticles and metal oxide properties. Researchers all over world are using these materials as coating agent for create an environment. This comprehensive contemporary review summarizes metals, nanoparticles, nanomaterials, their composites that used or may be future well succinct mode action combat biofilm-associated infection diseases.

Language: Английский

Citations

77
Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways DOI Creative Commons
Chuang Yang, Yao Luo, Hao Shen

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 18, 2022

Abstract Strategies to manipulate immune cell co-inhibitory or co-activating signals have revolutionized immunotherapy. However, certain immunologically cold diseases, such as bacterial biofilm infections of medical implants are hard target due the complexity co-stimulatory pathways involved. Here we show that two-dimensional manganese chalcogenophosphates MnPSe 3 (MPS) nanosheets modified with polyvinylpyrrolidone (PVP) capable triggering a strong anti-bacterial humoral immunity in mouse model surgical implant infection via modulating antigen presentation and costimulatory molecule expression infectious microenvironment (IME). Mechanistically, PVP-modified MPS (MPS-PVP) damages structure which results exposure by generating reactive oxidative species, while changing balance immune-inhibitory (IL4I1 CD206) co-activator (CD40, CD80 CD69). This leads amplified APC priming presentation, resulting biofilm-specific memory responses. In our work, demonstrate pre-surgical neoadjuvant immunotherapy utilizing MPS-PVP successfully mitigates residual recurrent following removal infected implants. study thus offers an alternative replace antibiotics against hard-to-treat infections.

Language: Английский

Citations

76
Alternative Copper-Based Single-Atom Nanozyme with Superior Multienzyme Activities and NIR-II Responsiveness to Fight against Deep Tissue Infections DOI Creative Commons
Jiaxiang Bai, Yonghai Feng, Wenming Li

et al.

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Nanozymes are considered to represent a new era of antibacterial agents, while their efficiency is limited by the increasing tissue depth infection. To address this issue, here, we report copper and silk fibroin (Cu-SF) complex strategy synthesize alternative single-atom nanozymes (SAzymes) with atomically dispersed sites anchored on ultrathin 2D porous N-doped carbon nanosheets (CuN x -CNS) tunable N coordination numbers in CuN (x = 2 or 4). The -CNS SAzymes inherently possess triple peroxidase (POD)-, catalase (CAT)-, oxidase (OXD)-like activities, facilitating conversion H2O2 O2 into reactive oxygen species (ROS) through parallel POD- OXD-like cascaded CAT- reactions. Compared CuN2-CNS, tailoring number from 4 endows SAzyme (CuN4-CNS) higher multienzyme activities due its superior electron structure lower energy barrier. Meanwhile, display strong absorption second near-infrared (NIR-II) biowindow deeper penetration, offering NIR-II-responsive enhanced ROS generation photothermal treatment deep tissues. vitro vivo results demonstrate that optimal CuN4-CNS can effectively inhibit multidrug-resistant bacteria eliminate stubborn biofilms, thus exhibiting high therapeutic efficacy both superficial skin wound implant-related biofilm infections.

Language: Английский

Citations

56
Emerging 2D MXenes for antibacterial applications: Current status, challenges, and prospects DOI
Xiaojun He, Seyoung Koo, Enoch Obeng

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 492, P. 215275 - 215275

Published: June 7, 2023

Language: Английский

Citations

54