Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(13)

Published: Feb. 27, 2022

Infections are regarded as the most severe complication associated with human health, which urgent to be solved. Stimuli-responsive materials appealing therapeutic platforms for antibacterial treatments, provide great potential accurate theranostics. In this review, advantages, response mechanisms, and key design principles of stimuli-responsive highlighted. The biomedical applications, current challenges, future directions also discussed. First, categories comprehensively itemized based on different sources stimuli, including external physical environmental stimuli (e.g., temperature, light, electricity, salt, etc.) bacterial metabolites acid, enzyme, redox, etc.). Second, structural characteristics, principles, applications responsive discussed, underlying interrelationships revealed. molecular structures closely related stimuli. Finally, challenging issues proposed. This review will scientific guidance promote clinical materials.

Language: Английский

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Near infrared fluorescent probes for detecting and imaging active small molecules

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

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Advanced Nitric Oxide Generating Nanomedicine for Therapeutic Applications

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 8935 - 8965

Published: May 1, 2023

Nitric oxide (NO), a gaseous transmitter extensively present in the human body, regulates vascular relaxation, immune response, inflammation, neurotransmission, and other crucial functions. Nitrite donors have been used clinically to treat angina, heart failure, pulmonary hypertension, erectile dysfunction. Based on NO's vast biological functions, it further can tumors, bacteria/biofilms infections, wound healing, eye diseases, osteoporosis. However, delivering NO is challenging due uncontrolled blood circulation release half-life of under five seconds. With advanced biotechnology development nanomedicine, packaged with multifunctional nanocarriers by physically embedding or chemically conjugating reported show improved therapeutic efficacy reduced side effects. Herein, we review discuss recent applications nanomedicines, their mechanisms, challenges nanomedicines for future scientific studies clinical applications. As enables inhibition replication DNA RNA infectious microbes, including COVID-19 coronaviruses malaria parasites, highlight potential antipandemic efforts. This aims provide deep insights practical hints into design strategies nanomedicines.

Language: Английский

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Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 458, P. 214438 - 214438

Published: Feb. 3, 2022

Language: Английский

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Sustained Release of Nitric Oxide and Cascade Generation of Reactive Nitrogen/Oxygen Species via an Injectable Hydrogel for Tumor Synergistic Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(36)

Published: July 30, 2022

Abstract Reactive nitrogen species (RNS) generated via the reaction of nitric oxide (NO) with reactive oxygen (ROS) are more lethal than ROS, and thus RNS‐mediated therapy has great potential in cancer treatment, yet it is still largely unexploited. Herein, a novel, injectable NO‐releasing hydrogel (NO‐Gel) composed α‐(nitrate ester) acetic acid‐modified amphiphilic copolymers developed. To further convert released NO to RNS, glutathione (GSH)‐sensitive CuCys nanoparticles (NPs) β‐lapachone (Lapa) co‐loaded into NO‐Gel. This system possesses temperature‐induced sol‐gel transition can continuously liberate Lapa, NPs, vitro for up 3 weeks. The sustained supply Lapa efficiently boost hydrogen peroxide (H 2 O ) concentration cells, intracellular GSH induce rapid release reduction NPs. With elevating H levels producing highly Cu(I), Cu(I)‐catalyzed Fenton‐like dramatically enhanced, resulting generation abundant hydroxyl radicals (·OH), subsequent cascade reactions among ·OH, 2, cause RNS pool. After single peritumoral injection system, ROS plus substantial depletion significantly suppress tumor growth.

Language: Английский

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Targeted nanomedicine in cisplatin-based cancer therapeutics

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 709 - 720

Published: March 31, 2022

Language: Английский

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A NIR‐II AIEgen‐Based Supramolecular Nanodot for Peroxynitrite‐Potentiated Mild‐Temperature Photothermal Therapy of Hepatocellular Carcinoma

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(19)

Published: Feb. 13, 2023

Abstract Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild‐temperature PTT is a more promising antitumor strategy with much lower phototoxicity neighboring normal tissues. However, the therapeutic efficacy of always restricted by thermoresistance cancer cells. To address this issue, supramolecular drug nanocarrier fabricated co‐deliver nitric oxide (NO) and agent DCTBT NIR‐II aggregation‐induced emission (AIE) characteristic for PTT. NO can be effectively released from nanocarriers in intracellular reductive environment capable simultaneously producing reactive oxygen species (ROS) upon 808 nm laser irradiation. The generated ROS further react produce peroxynitrite (ONOOˉ) bearing strong oxidization nitration capability. ONOOˉ inhibit expression heat shock proteins (HSP) reduce cells, necessary achieve excellent DCTBT‐based at mild temperature (<50 °C). performance ONOOˉ‐potentiated validated on subcutaneous orthotopic hepatocellular carcinoma (HCC) models. This research puts forward an innovative overcome PTT, provides new inspirations explore ONOOˉ‐sensitized tumor strategies.

Language: Английский

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Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

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Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

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