Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(14)
Published: Feb. 27, 2024
Abstract
Avascular
dense
connective
tissues
(e.g.,
the
annulus
fibrosus
(AF)
rupture,
meniscus
tear,
and
tendons
ligaments
injury)
repair
remains
a
challenge
due
to
“biological
barrier”
that
hinders
traditional
drug
permeation
limits
self‐healing
of
injured
tissue.
Here,
accurate
delivery
nitric
oxide
(NO)
penetrate
“AF
biological
is
achieved
thereby
enabling
programmable
AF
repair.
NO‐loaded
BioMOFs
are
synthesized
mixed
in
modified
polyvinyl
alcohol
PCL‐composited
electrospun
fiber
membrane
with
excellent
reactive
oxygen
species‐responsive
capability
(LN@PM).
The
results
show
LN@PM
could
respond
high
oxidative
stress
environment
at
tissue
realize
continuous
substantial
NO
release.
Based
on
low
molecular
weight
lipophilicity,
through
for
delivery.
Moreover,
dynamic
characteristics
reaction
can
be
matched
pathological
microenvironment
initiate
including
sequential
remodeling
microenvironment,
reprogramming
immune
environment,
finally
promoting
regeneration.
This
tailored
treatment
strategy
matches
process
significantly
repairs
AF,
ultimately
alleviating
intervertebral
disc
degeneration.
study
highlights
promising
approach
avascular
intelligent
release,
effectively
overcoming
barriers”
treatment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(3), P. 2355 - 2369
Published: Jan. 10, 2024
Functional
recovery
following
a
spinal
cord
injury
(SCI)
is
challenging.
Traditional
drug
therapies
focus
on
the
suppression
of
immune
responses;
however,
strategies
for
alleviating
oxidative
stress
are
lacking.
Herein,
we
developed
zinc–organic
framework
(Zn@MOF)-based
aggregation-induced
emission–active
nanozymes
accelerating
SCI.
A
multifunctional
Zn@MOF
was
modified
with
molecule
2-(4-azidobutyl)-6-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)-1H-phenalene-1,3-dione
via
bioorthogonal
reaction,
and
resulting
were
denoted
as
Zn@MOF-TPD.
These
gradually
released
gallic
acid
zinc
ions
(Zn2+)
at
SCI
site.
The
acid,
scavenger
reactive
oxygen
species
(ROS),
promoted
antioxidation
alleviated
inflammation,
re-establishing
balance
between
ROS
production
antioxidant
defense
system.
Zn2+
inhibited
activity
matrix
metalloproteinase
9
(MMP-9)
to
facilitate
regeneration
neurons
ROS-mediated
NF-κB
pathway
secondary
In
addition,
Zn@MOF-TPD
protected
myelin
sheaths
against
trauma,
glial
scar
formation,
proliferation
differentiation
neural
stem
cells,
thereby
facilitating
repair
injured
tissue
promoting
functional
in
rats
contusive
Altogether,
this
study
suggests
that
possess
potential
stress-mediated
pathophysiological
damage
motor
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 24, 2024
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(17)
Published: Jan. 2, 2024
Abstract
Gas
therapy,
represented
by
nitric
oxide
(NO),
has
shown
a
powerful
anti‐tumor
effect.
However,
current
NO
therapy
relies
on
precursors,
which
are
often
released
prematurely
during
in
vivo
delivery,
resulting
poor
targeting
and
obvious
toxic
side
effects.
Herein,
core/shell‐structured
nanocatalyst
is
designed
prepared
to
catalyze
the
generation
of
tumor
without
introduction
donor.
In
this
system,
C‐Z@CM
coating
octahedron
Cu‐MOF
with
nano‐ZnO,
camouflaging
homologous
cell
membrane.
After
nanomedicine
taken
up
cells,
ZnO
reacts
situ
endogenous
S‐nitrosoglutathione
(GSNO),
highly
expressed
tumors,
continuously
stably
generate
NO.
addition,
dispersed
copper
ions
acts
as
catalytic
active
centers
Fenton‐like
reaction,
catalyzes
H
2
O
large
number
hydroxyl
radicals
(
•
OH).
Importantly,
cascade
reactive
oxygen
species
(ROS)
leads
massive
production
more
lethal
nitrogen
(RNS),
further
enhancing
therapeutic
Catalytic
high
concentrations
tumor,
combined
ROS
RNS,
accompanied
glutathione
(GSH)
depletion,
achieving
effective
suppression.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
34, P. 414 - 421
Published: Jan. 10, 2024
Tumor
hypoxia
diminishes
the
effectiveness
of
traditional
type
II
photodynamic
therapy
(PDT)
due
to
oxygen
consumption.
Type
I
PDT,
which
can
operate
independently
oxygen,
is
a
viable
option
for
treating
hypoxic
tumors.
In
this
study,
we
have
designed
and
synthesized
JSK@PEG-IR820
NPs
that
are
responsive
tumor
microenvironment
(TME)
enhance
PDT
through
glutathione
(GSH)
depletion.
Our
approach
aims
expand
sources
therapeutic
benefits
by
promoting
generation
superoxide
radicals
(O
Small Methods,
Journal Year:
2024,
Volume and Issue:
8(8)
Published: Jan. 9, 2024
Abstract
Oxygen
(O
2
),
nitric
oxide
(NO),
carbon
monoxide
(CO),
hydrogen
sulfide
(H
S),
and
)
with
direct
effects,
dioxide
(CO
complementary
effects
on
the
condition
of
various
diseases
are
known
as
therapeutic
gases.
The
targeted
delivery
in
situ
generation
these
gases
controllable
release
at
site
disease
has
attracted
attention
to
avoid
risk
gas
poisoning
improve
their
performance
treating
such
cancer
therapy,
cardiovascular
bone
tissue
engineering,
wound
healing.
Stimuli‐responsive
gas‐generating
sources
systems
based
biomaterials
that
enable
on‐demand
promising
approaches
for
precise
therapy.
This
work
highlights
current
advances
design
development
new
generate
deliver
behavior.
delivered
biomedical
applications
is
then
discussed.
Small,
Journal Year:
2024,
Volume and Issue:
20(31)
Published: March 6, 2024
Abstract
Photothermal
treatment
(PTT)
has
emerged
as
a
promising
avenue
for
biofilm
elimination,
yet
its
potential
drawbacks,
such
local
hyperpyrexia
and
bacterial
heat
resistance,
have
posed
challenges.
To
address
these
concerns,
an
innovative
nanoplatform
(Au@mSiO
2
‐arg/ICG)
is
devised
that
integrates
phototherapeutic
gas
therapeutic
functionalities.
This
multifaceted
composed
of
mesoporous
silica‐coated
Au
nanorods
),
supplemented
with
l
‐arginine
(
‐arg)
indocyanine
green
(ICG),
engineered
mild
temperature
PTT
aimed
at
eradication.
Au@mSiO
‐arg/ICG
nanoparticles
(NPs)
show
excellent
antibacterial
effects
through
the
generation
nitric
oxide
(NO)
gas,
heat,
reactive
oxygen
species
(ROS)
under
808
nm
light
irradiation.
The
ROS
generated
by
ICG
initiates
cascade
reaction
‐arg,
ultimately
yielding
NO
molecules.
localized
release
not
only
effectively
curbs
expression
shock
proteins
70
mitigating
thermoresistance,
but
also
reduces
extracellular
polymeric
substance
allowing
better
penetration
agents.
Furthermore,
this
achieves
outstanding
elimination
rate
over
99%
in
abscess
model
irradiation
(0.8
W·cm
−2
thereby
establishing
dependable
strategy
NO‐enhanced
photodynamic
therapy
(aPDT)
clinical
settings.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(38), P. 44763 - 44772
Published: Sept. 15, 2023
Nanomaterials
with
intrinsic
enzyme-like
activities
(nanozymes)
have
gained
significant
attention
in
cancer
catalytic
therapy;
however,
developing
metal-free
nanozymes
multivariant
activity
as
the
"all-rounder"
for
therapy
remains
challenging.
Herein,
a
covalent
organic
framework
(COF)
derived
carbon-based
nanozyme
is
rationally
devised
to
achieve
synergistic
and
second
near-infrared
(NIR-II)
photothermal
of
cancer.
The
developed
possesses
activities,
including
oxidase
(OXD)-like,
catalase
(CAT)-like,
peroxidase
(POD)-like
which
enables
produce
adequate
reactive
oxygen
species
(ROS)
cell
killing.
Furthermore,
showed
excellent
converting
that
could
kill
cells
upon
NIR-II
laser
irradiation,
owing
strong
absorption
capacity
materials.
It
also
worth
noting
exhibited
cytotoxicity
specifically
tumor
tissue
profiting
from
discrepant
H2O2
level
between
normal
spatiotemporal
controllability
irradiation.
This
work
may
inspire
further
development
intelligent
biological
applications
across
broad
therapeutic
biomedical
fields.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Dec. 4, 2023
Bacterial
infection
in
skin
and
soft
tissue
has
emerged
as
a
critical
concern.
Overreliance
on
antibiotic
therapy
led
to
numerous
challenges,
including
the
emergence
of
multidrug-resistant
bacteria
adverse
drug
reactions.
It
is
imperative
develop
non-antibiotic
treatment
strategies
that
not
only
exhibit
potent
antibacterial
properties
but
also
promote
rapid
wound
healing
demonstrate
biocompatibility.
Herein,
novel
multimodal
synergistic
system
(SNO-CS@MoS2)
was
developed.
This
employs
easily
surface-modified
thin-layer
MoS2
photothermal
agents
loaded
with
S-nitrosothiol-modified
chitosan
(SNO-CS)
via
electrostatic
interactions,
thus
realizing
combination
NO
gas
(PTT).
Furthermore,
this
surface
modification
renders
SNO-CS@MoS2
highly
stable
capable
binding
bacteria.
Through
PTT's
thermal
energy,
rapidly
generates
massive
NO,
collaborating
PTT
achieve
effects.
can
swiftly
disrupt
bacterial
membrane,
causing
protein
leakage
ATP
synthesis
function
damage,
ultimately
eliminating
Notably,
after
effectively
all
bacteria,
residual
create
trace
fibroblast
migration,
proliferation,
vascular
regeneration,
thereby
accelerating
healing.
study
concluded
SNO-CS@MoS2,
multifunctional
nanomaterial
outstanding
characteristics
potential
healing,
promising
applications
infected
treatment.
