Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

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Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Language: Английский

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Multifunctional ZnCo₂O₄ Quantum Dots Encapsulated In Carbon Carrier for Anchoring/Catalyzing Polysulfides and Self‐Repairing Lithium Metal Anode in Lithium‐Sulfur Batteries

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(12)

Published: Dec. 1, 2021

Abstract Lithium‐sulfur batteries have recently attracted academic/industrial attention due to the high theoretical energy density. However, capacity decay mainly caused by polysulfides shuttle effect and poor conductivity of sulfur. Herein, in situ growth ZnCo 2 O 4 quantum dots (ZCO‐QDs) embedded into hollow carbon‐carrier sphere (HCS) form nanocapsule (ZCO‐QDs@HCS) as multifunctional sulfur host is rationally demonstrated. Based on density‐functional theory calculations, spectroscopic techniques, electrochemical studies, synergistic effects anchoring/catalyzing polysulfide ZCO‐QDs@HCS composite Li‐S investigated. Interestingly, also allows for controlled release ZCO‐QDs electrolyte. Subsequently, it first discovered that these diffused can act self‐repairing initiators stabilize Li metal anodes via rebuilding damaged solid electrolyte interphase suppressing dendrites growth. With this concept, dots‐based catalyst delivery systems constructed a battery, which similar use nanocarrier‐based drug cancer therapy. The cells with S@ZCO‐QDs@HCS cathode display significantly superior performances specific (1350.5 mAh·g −1 at 0.1 C) excellent cycling stability (capacity rate 0.057% per cycle after 1000 cycles 3.0 C).

Language: Английский

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Copper‐based nanomaterials for cancer theranostics

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 14(4)

Published: April 13, 2022

Abstract Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one most widely studied materials in cancer treatment. In recent years, great progress has been made field biomedicine, especially treatment diagnosis tumors. This review begins classification synthetic strategies NMs. Then, according to abundant special NMs, their application biomedicine is summarized detail. For imaging, such as photoacoustic positron emission tomography multimodal imaging based on summarized, well improve diagnostic effectiveness. Moreover, a series structures functions underlying property activity relationship were shown highlight promising therapeutic performance. used monotherapies, photothermal therapy (PTT) chemodynamic (CDT). sophisticated design composition, structure, surface fabrication can endow these more modalities therapy. To further efficiency treatment, combined was introduced Finally, challenges, critical factors, future prospects for clinical translation multifunctional theranostic agents also considered discussed. The aim this provide better understanding key consideration rational increasingly important new paradigm agents. article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools Vivo Nanodiagnostics Imaging

Language: Английский

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Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy

Small, Journal Year: 2022, Volume and Issue: 18(41)

Published: Sept. 11, 2022

Abstract It is highly desirable to design a single modality that can simultaneously trigger apoptosis and ferroptosis efficiently eliminate tumor progression. Herein, nanosystem based on the intrinsic properties of microenvironment (TME) designed achieve control through simultaneous induction apoptosis. CuCP molecules are encapsulated in liposome‐based assemble into biocompatible stable nanoparticles (CuCP Lipo NPs). This intrinsically possesses nanozymatic activity photothermal characteristics due property Cu atoms structure NPs. demonstrated synergistic strategy increases intracellular lipid‐reactive oxides species, induces occurrence apoptosis, completely eradicates tumors vivo. Proteomics analysis further discloses key involved proteins (including Tp53, HMOX1, Ptgs2, Tfrc, Slc11a2, Mgst2, Sod1, several GST family members) pathways ferroptosis, ROS synthesis). Conclusively, this work develops one synergistically induce vivo for suppression, which holds great potential clinical translation therapy.

Language: Английский

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Advances in Single-component inorganic nanostructures for photoacoustic imaging guided photothermal therapy

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 192, P. 114644 - 114644

Published: Dec. 6, 2022

Language: Английский

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Recent advances in augmenting Fenton chemistry of nanoplatforms for enhanced chemodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 479, P. 215004 - 215004

Published: Dec. 31, 2022

Language: Английский

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Is polydopamine beneficial for cells on the modified surface?

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Abstract Since the pioneering work of Messersmith’s group discovering that polydopamine (PDA) can serve to adhere many types materials, PDA coating has, as a biomimetic approach, been widely used enhance cell adhesion by surface modification bind biologically active substances bioinert substrate. Nevertheless, it is unclear whether or not itself beneficial for cells. Herein, we report decreases viability cells under normal culture and observation conditions. Such an inhibition effect was caused free any inherent cytotoxicity this chemical substance but contact-dependent phenomenon. Human bone marrow mesenchymal stem were employed default type tissue plates substrate, although some other substrates also examined confirm universality such ‘abnormal’ phenomenon superstar molecule. The on exhibited time dependence, decreased during found come from decrease number instead average per cell. led less global migration yet more local motility Based concept ‘background adhesion’ without significant motifs specific adhesion, supposed adhered better, which influenced mobility eventually proliferation. Hence, behaviors are reasonable, albeit bit complicated.

Language: Английский

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Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(20)

Published: March 18, 2023

Abstract The tumor microenvironment (TME) is a complex and variable region characterized by hypoxia, low pH, high redox status, overexpression of enzymes, high‐adenosine triphosphate concentrations. In recent years, with the continuous in‐depth study nanomaterials, more TME‐specific response nanomaterials are used for treatment. However, complexity TME causes different types responses various strategies mechanisms action. Aiming to systematically demonstrate advances in research on TME‐responsive this work summarizes characteristics outlines responses. Representative reaction illustrated their merits demerits analyzed. Finally, forward‐looking views TME‐response presented. It envisaged that such emerging treatment cancer expected exhibit dramatic trans‐clinical capabilities, demonstrating extensive potential diagnosis therapy cancer.

Language: Английский

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A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu₂O‐Supported MoS₂ Nanoflowers for Anticancer Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 20, 2023

The fast conversion of hydrogen peroxide (H2 O2 ) into reactive oxygen species (ROS) at tumor sites is a promising anticancer strategy by manipulating nanomedicines with near-infrared light in the second region (NIR-II). However, this greatly compromised powerful antioxidant capacity tumors and limited ROS generation rate nanomedicines. This dilemma mainly stems from lack an effective synthesis method to support high-density copper-based nanocatalysts on surface photothermal nanomaterials. Herein, multifunctional nanoplatform (MCPQZ) cuprous (Cu2 O) supported molybdenum disulfide (MoS2 nanoflowers (MC NFs) developed for efficient killing via potent storm innovative method. Under NIR-II irradiation, intensity maximum reaction velocity (Vmax produced MC NFs are 21.6 33.8 times that non-irradiation group vitro, which much higher than most current Moreover, strong cancer cells efficiently formed MCPQZ (increased 27.8 compared control), thanks fact effectively pre-weakens multiple systems cells. work provides novel insight solve bottleneck ROS-based therapy.

Language: Английский

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