Design and Mechanism Insight of Monodispersed AuCuPt Alloy Nanozyme with Antitumor Activity

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20402 - 20423

Published: Oct. 9, 2023

The abrogation of the self-adaptive redox evolution tumors is promising for improving therapeutic outcomes. In this study, we designed a trimetallic alloy nanozyme AuCuPt-PpIX (ACPP), which mimics up to five naturally occurring enzymes: glucose oxidase (GOD), superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and glutathione (GPx). Facilitated by these enzyme-mimicking traits, constructed ACPP nanozymes can not only disrupt established homeostasis in through series enzymatic cascade reactions but also achieve cyclic regeneration relevant enzyme substrates. Density functional theory (DFT) calculations have theoretically explained synergistic effect multimetallic doping possible mechanism catalysis. doped Cu Pt sites are conducive adsorption, activation, dissociation reactant molecules, whereas Au desorption, significantly improves catalytic efficiency via effect. Additionally, improve protoporphyrin (PpIX)-enabled sonodynamic therapy (SDT) alleviating hypoxia initiating ferroptosis inducing lipid peroxidation (LPO) inhibiting GPX4 activity, thus achieving multimodal therapy. This study presents typical paradigm enable use treatment tumor cells with properties.

Language: Английский

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Hyaluronic Acid‐Based Reactive Oxygen Species‐Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)

Published: Nov. 9, 2023

Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is assess a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for the purpose diabetic wound healing. A (HA@Cur@Ag) successfully synthesized with dual antioxidant, antibacterial, anti-inflammatory properties by crosslinking thiol hyaluronic acid (SH-HA) disulfide-bonded hyperbranched polyethylene glycol (HB-PBHE) through Michael addition; while, incorporating curcumin liposomes silver nanoparticles (AgNPs). HA@Cur@Ag exhibits favorable biocompatibility, degradability, injectivity. outcomes in vitro vivo experiments demonstrate that can effectively be loaded release liposomes, as well ions, thereby facilitating healing multiple mechanisms, including ROS scavenging, bactericidal activity, effects, promotion angiogenesis. Transcriptome sequencing reveals suppresses activation tumour necrosis factor (TNF)/nuclear κB (NF-κB) pathway ameliorate oxidative stress inflammation These findings suggest ROS-responsive hydrogel, which possesses ability precisely coordinate integrate intricate biological molecular processes involved healing, notable potential expediting

Language: Английский

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Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 27, 2024

Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.

Language: Английский

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Synergistic Interaction between Metal Single‐Atoms and Defective WO_3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Language: Английский

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Osteomyelitis and non-coding RNAS: A new dimension in disease understanding

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155186 - 155186

Published: Feb. 2, 2024

Language: Английский

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